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Erschienen in: European Journal of Pediatrics 4/2019

14.01.2019 | Original Article

Human parechovirus meningitis and gross-motor neurodevelopment in young children

verfasst von: Ted M. T. van Hinsbergh, Stephanie C. M. de Crom, Robert Lindeboom, Marceline A. M. van Furth, Charlie C. Obihara

Erschienen in: European Journal of Pediatrics | Ausgabe 4/2019

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Abstract

This multicenter prospective cohort study describes the impact of human parechovirus meningitis on gross-motor neurodevelopment of young children. Gross-motor function was measured using Alberta Infant Motor Scale. Of a total of 38 eligible children < 10 months of age at onset, nine cases had clinical evidence of meningitis and polymerase chain reaction positive for human parechovirus in cerebrospinal fluid; 11 had no meningitis and polymerase chain reaction positive for human parechovirus in nasopharyngeal aspirate, blood, urine, or feces; and in 18, no pathogen was identified (reference group).
The children with human parechovirus meningitis showed more frequent albeit not statistically significant suspect gross-motor function delay (mean Z-score (standard deviation) − 1.69 (1.05)) than children with human parechovirus infection-elsewhere (− 1.38 (1.51)). The reference group did not fall in the range of suspect gross-motor function delay (− 0.96 (1.07)). Adjustment for age at onset and maternal education did not alter the results.
Conclusion: Six months after infection, children with human parechovirus meningitis showed more frequent albeit not statistically significant suspect gross-motor function delay compared to the population norm and other two groups. Longitudinal studies in larger samples and longer follow-up periods are needed to confirm the impact and persistence of human parechovirus meningitis on neurodevelopment in young children.
What is Known:
• Human parechovirus is progressively becoming a major viral cause of meningitis in children.
• There is keen interest in the development of affected infants with human parechovirus meningitis.
What is New:
• This study describes prospectively gross-motor functional delay in children with both clinical evidence of meningitis and polymerase chain reaction positive for human parechovirus in cerebrospinal fluid.
• It shows the importance of screening young children for developmental delay in order to refer those with delay for early intervention to maximize their developmental potential.
Literatur
1.
Zurück zum Zitat Barnett A, Mercuri E, Rutherford M, Haataj L, Frisone MF, Henderson S, Cowan F, Dubowitz L (2002) Neurological and perceptual-motor outcome at 5 - 6 years of age in children with neonatal encephalopathy: relationship with neonatal brain MRI. Neuropediatrics 33:242–248. https://doi.org/10.1055/s-2002-36737 CrossRefPubMed Barnett A, Mercuri E, Rutherford M, Haataj L, Frisone MF, Henderson S, Cowan F, Dubowitz L (2002) Neurological and perceptual-motor outcome at 5 - 6 years of age in children with neonatal encephalopathy: relationship with neonatal brain MRI. Neuropediatrics 33:242–248. https://​doi.​org/​10.​1055/​s-2002-36737 CrossRefPubMed
3.
Zurück zum Zitat Benschop KS, Schinkel J, Minnaar RP, Pajkrt D, Spanjerberg L, Kraakman HC, Berkhout B, Zaaijer HL, Beld MG, Wolthers KC (2006) Human parechovirus infections in Dutch children and the association between serotype and disease severity. Clin Infect Dis 42:204–210. https://doi.org/10.1086/498905 CrossRefPubMed Benschop KS, Schinkel J, Minnaar RP, Pajkrt D, Spanjerberg L, Kraakman HC, Berkhout B, Zaaijer HL, Beld MG, Wolthers KC (2006) Human parechovirus infections in Dutch children and the association between serotype and disease severity. Clin Infect Dis 42:204–210. https://​doi.​org/​10.​1086/​498905 CrossRefPubMed
7.
Zurück zum Zitat Cabrerizo M, Díaz-Cerio M, Muñoz-Almagro C, Rabella N, Tarragó D, Romero MP, Pena MJ, Calvo C, Sonia R, Antonio M, Rienda IM, Otero A, Trallero G (2017) Molecular epidemiology of enterovirus and parechovirus infections according to patient age over a 4-year period in Spain. J Med Virol 89:435–442. https://doi.org/10.1002/jmv.24658 CrossRefPubMed Cabrerizo M, Díaz-Cerio M, Muñoz-Almagro C, Rabella N, Tarragó D, Romero MP, Pena MJ, Calvo C, Sonia R, Antonio M, Rienda IM, Otero A, Trallero G (2017) Molecular epidemiology of enterovirus and parechovirus infections according to patient age over a 4-year period in Spain. J Med Virol 89:435–442. https://​doi.​org/​10.​1002/​jmv.​24658 CrossRefPubMed
16.
Zurück zum Zitat Hadders- Algra M (2000) The neuronal group selection theory: a framework to explain variation in normal motor development. Dev Med Child Neurol 42:566–572CrossRefPubMed Hadders- Algra M (2000) The neuronal group selection theory: a framework to explain variation in normal motor development. Dev Med Child Neurol 42:566–572CrossRefPubMed
17.
22.
Zurück zum Zitat Piper MC, Darrah J (1994) Motor assessment of the developing infant, 1rd edn. WB Saunders, Philadelphia Piper MC, Darrah J (1994) Motor assessment of the developing infant, 1rd edn. WB Saunders, Philadelphia
26.
Zurück zum Zitat Tapiainen T, Prevots R, Izurieta HS, Abramson J, Bilynsky R, Bonhoeffer J, Bonnet MC, Center K, Galama J, Gillard P, Griot M, Hartmann K, Heininger U, Hudson H, Koller A, Khetsuriani N, Khuri-Bulos N, Marcy SM, Matulionyte R, Schöndorf I, Sejvar J, Steele R, The Brighton Collaboration Aseptic Meningitis Working Group (2007) Aseptic meningitis: case definition and guidelines for collection, analysis and presentation of immunization safety data. Vaccine 25:5793–5802. https://doi.org/10.1016/j.vaccine.2007.04.058 CrossRefPubMed Tapiainen T, Prevots R, Izurieta HS, Abramson J, Bilynsky R, Bonhoeffer J, Bonnet MC, Center K, Galama J, Gillard P, Griot M, Hartmann K, Heininger U, Hudson H, Koller A, Khetsuriani N, Khuri-Bulos N, Marcy SM, Matulionyte R, Schöndorf I, Sejvar J, Steele R, The Brighton Collaboration Aseptic Meningitis Working Group (2007) Aseptic meningitis: case definition and guidelines for collection, analysis and presentation of immunization safety data. Vaccine 25:5793–5802. https://​doi.​org/​10.​1016/​j.​vaccine.​2007.​04.​058 CrossRefPubMed
Metadaten
Titel
Human parechovirus meningitis and gross-motor neurodevelopment in young children
verfasst von
Ted M. T. van Hinsbergh
Stephanie C. M. de Crom
Robert Lindeboom
Marceline A. M. van Furth
Charlie C. Obihara
Publikationsdatum
14.01.2019
Verlag
Springer Berlin Heidelberg
Erschienen in
European Journal of Pediatrics / Ausgabe 4/2019
Print ISSN: 0340-6199
Elektronische ISSN: 1432-1076
DOI
https://doi.org/10.1007/s00431-019-03319-6

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