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Journal of NeuroVirology
Erschienen in: Journal of NeuroVirology 3/2019

28.01.2019 | Mini-Review

Human T cell leukemia virus type 1 and Zika virus: tale of two reemerging viruses with neuropathological sequelae of public health concern

verfasst von: DeGaulle I. Chigbu, Pooja Jain, Brenndan L. Crumley, Dip Patel, Zafar K. Khan

Erschienen in: Journal of NeuroVirology | Ausgabe 3/2019

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Abstract

Human T cell leukemia virus type 1 (HTLV-1) and Zika virus (ZIKV) have been considered neglected viruses of low public health concern until recently when incidences of HTLV-1 and ZIKV were observed to be linked to serious immune-related disease and neurological complications. This review will discuss the epidemiology, genomic evolution, virus-host interactions, virulence factors, neuropathological sequelae, and current perspectives of these reemerging viruses. There are no FDA-approved therapeutics or vaccines against these viruses, and as such, it is important for clinical trials to focus on developing vaccines that can induce cell-mediated immune response to confer long-term protective immunity. Furthermore, attention should be paid to reducing the transmission of these viruses through unprotected sex, infected blood during sharing of contaminated needles, donated blood and organs, and vertical transmission from mother to baby via breastfeeding. There is an urgent need to re-evaluate repurposing current antiviral therapies as well as developing novel antiviral agents with enhanced efficacy due to the high morbidity rate associated with these two reemerging chronic viral diseases.
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Metadaten
Titel
Human T cell leukemia virus type 1 and Zika virus: tale of two reemerging viruses with neuropathological sequelae of public health concern
verfasst von
DeGaulle I. Chigbu
Pooja Jain
Brenndan L. Crumley
Dip Patel
Zafar K. Khan
Publikationsdatum
28.01.2019
Verlag
Springer International Publishing
Erschienen in
Journal of NeuroVirology / Ausgabe 3/2019
Print ISSN: 1355-0284
Elektronische ISSN: 1538-2443
DOI
https://doi.org/10.1007/s13365-019-00720-7

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