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07.07.2017 | Urogenital | Ausgabe 1/2018

European Radiology 1/2018

Hyoscine butylbromide significantly decreases motion artefacts and allows better delineation of anatomic structures in mp-MRI of the prostate

Zeitschrift:
European Radiology > Ausgabe 1/2018
Autoren:
T. Ullrich, M. Quentin, A. K. Schmaltz, C. Arsov, C. Rubbert, D. Blondin, R. Rabenalt, P. Albers, G. Antoch, L. Schimmöller

Abstract

Objectives

To prospectively evaluate the effect of hyoscine butylbromide (HBB) on visualisation of anatomical details and motion-related artefacts in mp-MRI of the prostate at 3.0 Tesla.

Methods

One hundred and three consecutive patients (65 ± 10 years) were included in this trial, powered to demonstrate an improvement of image quality after HBB administration, assessed on a 5-point scale by two blinded readers. All patients received high-spatial resolution axial T2-weighted TSE sequences at 3.0 T without spasmolytic agent, repeated after application of 40 mg HBB and followed by routine mp-MRI. Secondary endpoints were (1) susceptibility to side effects, (2) dependence of spasmolytic effect on patients´ weight, and (3) prostate volume.

Results

In 68% of patients, HBB significantly improved the anatomic score (mean 3.4 ± 0.9 before and 4.4 ± 0.7 after HBB for both readers, p = <0.001). In 67%, HBB significantly enhanced the artefact score (mean 3.2 ± 1 before and 4.2 ± 0.8 after HBB for reader 1, p = <0.001; 3.2 ± 1 and 4.1 ± 0.8 for reader 2, p = <0.001). Subgroup analysis revealed no statistically significant difference between patients with different bodyweight or prostate volume. Inter-reader agreement was excellent (k = 0.95–0.98).

Conclusions

Hyoscine butylbromide significantly improves image quality and reduces motion-related artefacts in mp-MRI of the prostate independent of bodyweight or prostate volume. No side effects were reported.

Key Points

Hyoscine butylbromide (HBB) improved image quality in over 2/3 of patients.
Severe artefacts were reduced after HBB in more than 20%.
The number of non-diagnostic MRI was reduced to <1% after HBB.
HBB effect was independent of bodyweight and prostate volume.
No side effects of HBB were reported in this study population.

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