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05.12.2016 | Original Paper | Ausgabe 5/2017

Supportive Care in Cancer 5/2017

Hyperacute peripheral neuropathy is a predictor of oxaliplatin-induced persistent peripheral neuropathy

Zeitschrift:
Supportive Care in Cancer > Ausgabe 5/2017
Autoren:
Hiroyuki Tanishima, Toshiji Tominaga, Masamichi Kimura, Tsunehiro Maeda, Yasutsugu Shirai, Tetsuya Horiuchi

Abstract

Purpose

Chronic peripheral neuropathy is a major adverse response to oxaliplatin-containing chemotherapy regimens, but there are no established risk factors pertaining to it. We investigated the efficacy of hyperacute peripheral neuropathy (HAPN) as a predictor of oxaliplatin-induced persistent peripheral neuropathy (PPN).

Methods

Forty-seven cases of stage III colorectal cancer who received adjuvant chemotherapy with oxaliplatin after curative surgery between January 2010 and August 2014 were retrospectively reviewed. HAPN was defined as acute peripheral neuropathy (APN) occurring on day 1 (≤24 h after oxaliplatin infusion) of the first cycle. PPN was defined as neuropathy lasting >1 year after oxaliplatin discontinuation.

Results

The average total dose of oxaliplatin was 625.8 mg/m2, and the average relative dose intensity was 66.7%. Twenty-two of the 47 patients (46.8%) had PPN and 13 (27.7%) had HAPN. Male sex, treatment for neuropathy, HAPN, and APN were significantly more frequent in patients with PPN (p = 0.013, 0.02, <0.001, and 0.023, respectively). There was no significant difference in the total oxaliplatin dose between patients with and without PPN (p = 0.061). Multivariate analyses revealed total dose of oxaliplatin and HAPN as independent predictors of PPN [p = 0.015; odds ratio (OR) = 1.005, 95% confidence interval (CI), 1.001–1.009 and p = 0.001; OR = 75.307, 5.3–1070.123, respectively]. The total dose of oxaliplatin was relatively lower in patients with HAPN than that in those without HAPN in the PPN-positive group (not significant, p = 0.068).

Conclusion

HAPN was found to be a predictor of oxaliplatin-induced PPN.

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