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Erschienen in: Inflammation 5/2014

01.10.2014

Hyperoside Inhibits High-Glucose-Induced Vascular Inflammation In Vitro and In Vivo

verfasst von: Sae-Kwang Ku, Soyoung Kwak, O-Jun Kwon, Jong-Sup Bae

Erschienen in: Inflammation | Ausgabe 5/2014

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Abstract

Hyperoside, an active compound from the genera of Hypericum and Crataegus, was reported to have antioxidant, antihyperglycemic, anticancer, anti-inflammatory, and anticoagulant activities. Vascular inflammatory process has been suggested to play a key role in initiation and progression of atherosclerosis, a major complication of diabetes mellitus. Thus, in this study, we attempted to determine whether hyperoside can suppress vascular inflammatory processes induced by high glucose (HG) in human umbilical vein endothelial cells (HUVECs) and mice. Data showed that HG induced markedly increased vascular permeability, monocyte adhesion, expressions of cell adhesion molecules (CAMs), formation of reactive oxygen species (ROS), and activation of nuclear factor (NF)-κB. Remarkably, all of the above-mentioned vascular inflammatory effects of HG were attenuated by pretreatment with hyperoside. Vascular inflammatory responses induced by HG are critical events underlying development of various diabetic complications; therefore, our results suggest that hyperoside may have significant therapeutic benefits against diabetic complications and atherosclerosis.
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Metadaten
Titel
Hyperoside Inhibits High-Glucose-Induced Vascular Inflammation In Vitro and In Vivo
verfasst von
Sae-Kwang Ku
Soyoung Kwak
O-Jun Kwon
Jong-Sup Bae
Publikationsdatum
01.10.2014
Verlag
Springer US
Erschienen in
Inflammation / Ausgabe 5/2014
Print ISSN: 0360-3997
Elektronische ISSN: 1573-2576
DOI
https://doi.org/10.1007/s10753-014-9863-8

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