Skip to main content
Hauptrubriken
CME Facharzt-Training Webinare Zeitschriften Bücher e.Medpedia Podcast
Service
Jobbörse Info & Hilfe
Fachgebiete
Anästhesiologie Allgemeinmedizin Arbeitsmedizin Augenheilkunde Chirurgie Dermatologie Gynäkologie und Geburtshilfe HNO Innere Medizin Kardiologie Neurologie Onkologie und Hämatologie Orthopädie und Unfallchirurgie Pädiatrie Pathologie Psychiatrie Radiologie Rechtsmedizin Urologie Zahnmedizin
Themen
Typ-2-Diabetes und Adipositas Klimawandel und Gesundheit Neues aus dem Markt Praxis und Beruf Seltene Erkrankungen GOÄ & EBM Panorama
Sammlungen
Kasuistiken Algorithmen & Infografiken Blickdiagnosen Arthropedia FlapFinder (für Dermatochirurgen) Videos Kongressberichterstattung Medizin für Apothekerinnen und Apotheker Für Ärztinnen und Ärzte in Weiterbildung Für Medizinstudierende Patientenratgeber
Erweiterte Suche
Anmelden
nach oben
Aesthetic Plastic Surgery
Erschienen in:

23.03.2020 | Review

Hypersensitivity Caused by Cosmetic Injection: Systematic Review and Case Report

verfasst von: Chenyu Wang, Tianyu Sun, Hairui Li, Zhijin Li, Xiaojun Wang

Erschienen in: Aesthetic Plastic Surgery | Ausgabe 1/2021

Einloggen, um Zugang zu erhalten

Abstract

Objective

Botulinum toxin injection, micro-needling injection, and filler injection are the most widely used non-surgical facial cosmetic treatments. Hypersensitivity reactions associated with injections have not received sufficient attention due to their low incidence rates. The authors tried to summarize the characteristics of the hypersensitivity caused by cosmetic injections and helped to improve the diagnosis and treatment.

Methods

A comprehensive search of the PubMed database to September 2019 was performed. Articles were screened using predetermined inclusion and exclusion criteria. Data collected included patient characteristics, injection information (injected material, trade name, location of injection, symptoms of allergy, time of onset), diagnostic examination, treatment, and prognosis.

Results

A total of 14 articles (57 patients) were included. There were 3 patients receiving botulinum toxin injection, 3 patients receiving micro-needling injection, and 46 patients receiving hyaluronic acid injection. Five patients were injected with collagen, polyacrylamide, paraffin, alkyl-imide or hyaluronidase, separately. The symptoms were redness, swelling, itching or induration at the injection site. The diagnosis and treatment methods vary greatly depending on the injection fillers. Removing the injected filler is the primary treatment.

Conclusion

Although hypersensitivity reaction is a relatively uncommon adverse event, more practice guidelines and research on diagnosis and treatment are demanded to help improve the outcomes.

Level of Evidence III

This journal requires that authors assign a level of evidence to each article. For a full description of these evidence-based medicine ratings, please refer to the table of contents or the online instructions to authors www.​springer.​com/​00266.
Literatur
1.
2.
Massone C, Horn M, Kerl H et al (2009) Foreign body granuloma due to matridex injection for cosmetic purposes[J]. Am J Dermatopathol 31(2):197–199CrossRef
3.
Grippaudo FR, Mattei M (2010) High-frequency sonography of temporary and permanent dermal filers. Skin Res Technol 16:265–269PubMed
4.
Christensen L (2007) Normal and pathologic tissue reactions to soft tissue gel filers. Dermatol Surg 33(Suppl 2):S168–S175PubMed
5.
Kobayashi K, Kaneda K, Kasama T (2001) Immunopathogenesis of delayed-type hypersensitivity[J]. Microsc Res Tech 53:241–245CrossRef
6.
Pichler WJ (2003) Delayed drug hypersensitivity reactions[J]. Ann Intern Med 139:683–693CrossRef
7.
Jelinek C. Appendix E (1990) Diagnostic procedures-delayed hypersensitivity skin testing.In: Allergy/Immunology specialist course manual, 5th edn. US Army, E-1–11
8.
Roitt IM (1998) Essential immunology. 9th edn. Oxford, UK: Blackwell Scientific, Chapters 22–23
9.
Careta MF, Delgado L, Patriota R (2015) Report of allergic reaction after application of botulinum toxin[J]. Aesthet Surg J 35(5):NP102–NP105CrossRef
10.
Moon IJ, Chang SE, Kim SD (2017) First case of anaphylaxis after botulinum toxin type A injection[J]. Clin Exp Dermatol 42(7):760–762CrossRef
11.
Rosenfield LK, Kardassakis DG, Tsia KA et al (2014) The first case report of a systemic allergy to onabotulinumtoxinA (Botox) in a healthy patient[J]. Aesthet Surg J 34(5):766–768CrossRef
12.
Kamin W, Staubach P, Klär-Hlawatsch B (2006) Anaphylaxis after vaccination due to hypersensitivity to gelatin[J]. Klin Padiatr 218(2):92–94CrossRef
13.
Soltani-Arabshahi R, Wong JW, Duffy KL et al (2014) Facial allergic granulomatous reaction and systemic hypersensitivity associated with microneedle therapy for skin rejuvenation[J]. JAMA Dermatol 150(1):68–72CrossRef
14.
Cassuto D, Sundaram H (2013) A problem-oriented approach to nodular complications from hyaluronic acid and calcium hydroxylapatite fillers: classification and recommendations for treatment[J]. Plast Reconstr Surg 132(4 Suppl 2):48S–58SCrossRef
15.
Jeong ML, Yu JK (2015) Foreign body granulomas after the use of dermal fillers: pathophysiology, clinical appearance, histologic features, and treatment[J]. Arch Plast Surg 42(2):232–239CrossRef
16.
Lowe NJ, Maxwell CA, Patnaik R (2005) Adverse reactions to dermal fillers: review[J]. Dermatol Surg 31:1616–1625PubMed
17.
Lemperle G, Gauthier-Hazan N, Wolters M et al (2009) Foreign body granulomas after all injectable dermal fillers: part 1 Possible causes[J]. Plast Reconstr Surg 123(6):1842–1863CrossRef
18.
Bitterman-Deutsch O, Kogan L, Nasser F (2015) Delayed immune mediated adverse effects to hyaluronic acid fillers: report of five cases and review of the literature[J]. Dermatol Rep 7(1):5851CrossRef
19.
Alijotas-Reig J, Fernández-Figueras MT, Puig L (2013) Late-onset inflammatory adverse reactions related to soft tissue filler injections[J]. Clin Rev Allergy Immunol 45(1):97–108CrossRef
20.
Rongioletti F (2008) Granulomatous reactions from aesthetic dermal micro-implants[J]. Ann Dermatol Venereol 135(1 Pt 2):1S59–65PubMed
21.
Mohammed GT, Koenraad DB, Wolfgang PD (2019) Delayed hypersensitivity reaction to hyaluronic acid dermal filler following influenza-like illness[J]. Clin Cosmet Investig Dermatol 12:277–283CrossRef
22.
Shahrabi FS, Sexton J, Stone JD et al (2012) Lip nodules caused by hyaluronic acid filler injection: report of three cases[J]. Head Neck Pathol 6(1):16–20CrossRef
23.
Artzi O, Loizides C, Verner I (2016) Resistant and recurrent late reaction to hyaluronic acid-based gel[J]. Dermatol Surg 42(1):31–37CrossRef
24.
Kim MS, Youn S, Na CH et al (2015) Allergic reaction to hyaluronidase use after hyaluronic acid filler injection[J]. J Cosmet Laser Ther 17(5):283–285CrossRef
25.
Alijotas-Reig J, Fernández-Figueras MT, Puig L (2013) Inflammatory, immune-mediated adverse reactions related to soft tissue dermal fillers[J]. Semin Arthritis Rheum 43(2):241–258CrossRef
26.
Lee SK, Kim SM, Cho SH et al (2015) Adverse reactions to injectable soft tissue fillers: memorable cases and their clinico-pathological overview[J]. J Cosmet Laser Ther 17(2):102–108CrossRef
27.
Chang C, Lee SB (2015) Unusual long-term complication of polyalkylimide hydrogel manifesting as nasal septal abscess[J]. J Craniofac Surg 26(3):e197–e199CrossRef
28.
Bhojani-Lynch T (2017) Late-onset inflammatory response to hyaluronic acid dermal fillers[J]. Plast Reconstr Surg Glob Open 5(12):e1532CrossRef
29.
Kanoh S, Rubin BK (2010) Mechanisms of action and clinical application of macrolides as immunomodulatory medications. Clin Microbiol Rev 23:590–615CrossRef
30.
Chang JR, Baharestani S, Salek SS et al (2017) Delayed superficial migration of retained hyaluronic acid years following periocular injection[J]. Ophthalmic Plast Reconstr Surg 33(3S Suppl 1):S116–S118CrossRef
31.
Landau M (2015) Hyaluronidase caveats in treating filler complications[J]. Dermatol Surg 41(Suppl 1):S347–S353CrossRef
32.
Sundaram H, Voigts B, Beer K, Meland M (2010) Comparison of the rheological properties of viscosity and elasticity in two categories of soft tissue filers: calcium hydroxylapatite and hyaluronic acid. Dermatol Surg 36(Suppl 3):1859–1865CrossRef
33.
Glogau RG, Kane MA (2008) Effect of injection techniques on the rate of local adverse events in patients implanted with nonanimal hyaluronic acid gel dermal filers. Dermatol Surg 34(Suppl 1):S105–S109PubMed
34.
Sundaram H, Monheit GD, Goldman MP (2012) Clinical experiences with hyaluronic acid filers: roundtable discussion. J Drugs Dermatol 11:15–27
35.
Auler ME, Morreira D, Rodrigues FF et al (2010) Biofim formation on intrauterine devices in patients with recurrent vulvovaginal candidiasis. Med Mycol 48:211–216CrossRef
36.
Lewis K (2001) Riddle of biofim resistance. Antimicrob Ag Chemother 45:999–1007CrossRef
37.
Rohrich RJ, Monheit G, Nguyen AT, Brown SA, Fagien S (2010) Soft-tissue filer complications: the important role of biofims. Plast Reconstr Surg 125:1250–1256CrossRef
38.
Bjarnsholt T, Tolker-Nielsen T, Givskov M, Janssen M, Christensen LH (2009) Detection of bacteria by florescence in situ hybridization in culture-negative soft tissue filer lesions. Dermatol Surg 35(Suppl 2):1620–1624CrossRef
39.
Voigts R, DeVore DP, Neuman P, Grazer J (2010) Dispersion of calcium hydroxylapatite accumulations in the skin: animal studies and clinical practices. Dermatol Surg 36(Suppl):798–803CrossRef
Metadaten
Titel
Hypersensitivity Caused by Cosmetic Injection: Systematic Review and Case Report
verfasst von
Chenyu Wang
Tianyu Sun
Hairui Li
Zhijin Li
Xiaojun Wang
Publikationsdatum
23.03.2020
Verlag
Springer US
Erschienen in
Aesthetic Plastic Surgery / Ausgabe 1/2021
Print ISSN: 0364-216X
Elektronische ISSN: 1432-5241
DOI
https://doi.org/10.1007/s00266-020-01684-4

Weitere Artikel der Ausgabe 1/2021

Imaging of the Silicone Implant with a 3D SPACE MR Sequence: The Accuracy for Estimating Implant Volume and Reconstructing Implant Deformation in Breast Surgery

  • Original Article

Invited Discussion on “Awareness of Facial Asymmetry and Its Impact on Postoperative Satisfaction of Rhinoplasty Patient”

  • Editor’s Invited Commentary

Invited Discussion on: Dual-Plane Retro-Pectoral Versus Pre-pectoral DTI Breast Reconstruction—An Italian Multicenter Experience

  • Commentary & Discussion

Liposuction for Lipoedema: Functional Therapy or Aesthetic Procedure?

  • Video Submission

Preoperative Factors Associated with the Volume Discrepancy Before LD Flap Breast Reconstruction

  • Letter to the Editor

Invited Discussion on: Safety of Large-Volume Immediate Fat Grafting for Latissimus Dorsi-Only Breast Reconstruction: Results and Related Complications in 95 Consecutive Cases

  • Editor’s Invited Commentary

Neu im Fachgebiet Chirurgie

Verbände und Cremes gegen Dekubitus: „Wir wissen nicht, was sie bringen!“

Die Datenlage zur Wirksamkeit von Verbänden oder topischen Mitteln zur Prävention von Druckgeschwüren sei schlecht, so die Verfasser einer aktuellen Cochrane-Studie. Letztlich bleibe es unsicher, ob solche Maßnahmen den Betroffenen nutzen oder schaden.

Nackenschmerzen nach Bandscheibenvorfall: Muskeltraining hilft!

Bei hartnäckigen Schmerzen aufgrund einer zervikalen Radikulopathie schlägt ein Team der Universität Istanbul vor, lokale Steroidinjektionen mit einem speziellen Trainingsprogramm zur Stabilisierung der Nackenmuskulatur zu kombinieren.

US-Team empfiehlt Gastropexie nach Hiatushernien-Op.

Zur Vermeidung von Rezidiven nach Reparatur einer paraösophagealen Hiatushernie sollte einem US-Team zufolge der Magen bei der Op. routinemäßig an der Bauchwand fixiert werden. Das Ergebnis einer randomisierten Studie scheint dafür zu sprechen.

Mit Lidocain kommt der Darm nicht schneller in Schwung

Verzögertes Wiederanspringen der Darmfunktion ist ein Hauptfaktor dafür, wenn Patientinnen und Patienten nach einer Kolonresektion länger als geplant im Krankenhaus bleiben müssen. Ob man diesem Problem mit Lidocain vorbeugen kann, war Thema einer Studie.

Update Chirurgie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen
Bildnachweise