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Erschienen in:

25.01.2023 | Review

Hypertransaminasemia in cancer patients receiving immunotherapy and immune-based combinations: the MOUSEION-05 study

verfasst von: Alessandro Rizzo, Veronica Mollica, Valentina Tateo, Elisa Tassinari, Andrea Marchetti, Matteo Rosellini, Raffaele De Luca, Matteo Santoni, Francesco Massari

Erschienen in: Cancer Immunology, Immunotherapy | Ausgabe 6/2023

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Abstract

Background

The antitumor efficacy of immune checkpoint inhibitors (ICIs) has increasingly emerged during the last few years. However, there is a need to identify the safety profile of these agents more comprehensively, including liver toxicity.

Materials and methods

Herein, we performed a meta-analysis to assess the risk of all-grade and grade 3–4 hypertransaminasemia in cancer patients receiving ICIs—as monotherapy or in combination with other anticancer agents. All the relevant trials were retrieved through EMBASE, Cochrane Library, and PubMed/Medline databases; eligible studies were selected according to PRISMA statement. The pooled relative risk (RR) and 95% confidence interval (CI) were extracted.

Results

Fifty-nine studies were included. The pooled RRs for all-grade AST and ALT increase were 1.45 (95% CI 1.26–1.67) (Supplementary Fig. 3) and 1.51 (95% CI 1.29–1.77) in patients receiving ICIs monotherapy and immune-based combinations compared to control treatment, respectively. The pooled RRs for grade 3–4 AST and ALT increase were 2.16 (95% CI 1.77–2.64) and 2.3 (95% CI 1.91–2.77).

Conclusions

According to our results, ICIs monotherapy and immune-based combinations were associated with higher risk of all-grade and grade 3–4 hypertransaminasemia. Monitoring liver function should be recommended in cancer patients treated with ICIs monotherapy or immune-based combination, and in case of underlying liver disease, a careful risk–benefit assessment appears as a mandatory need.

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Titel: Hypertransaminasemia in cancer patients receiving immunotherapy and immune-based combinations: the MOUSEION-05 study
verfasst von: Alessandro Rizzo
Veronica Mollica
Valentina Tateo
Elisa Tassinari
Andrea Marchetti
Matteo Rosellini
Raffaele De Luca
Matteo Santoni
Francesco Massari
Publikationsdatum: 25.01.2023
Verlag: Springer Berlin Heidelberg
Erschienen in: Cancer Immunology, Immunotherapy / Ausgabe 6/2023
Print ISSN: 0340-7004
Elektronische ISSN: 1432-0851
DOI: https://doi.org/10.1007/s00262-023-03366-x

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23.04.2024 | Medikamente in Schwangerschaft und Stillzeit | Nachrichten

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Hypertransaminasemia in cancer patients receiving immunotherapy and immune-based combinations: the MOUSEION-05 study

Abstract

Background

Materials and methods

Results

Conclusions

Neu im Fachgebiet Onkologie

ICI-Therapie in der Schwangerschaft wird gut toleriert

Krebspatienten impfen: Was? Wen? Und wann nicht?

Müde im Alter? Auch an die Nebenniere denken

Stufenschema weist Prostatakarzinom zuverlässig nach

Update Onkologie

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Abstract

Background

Materials and methods

Results

Conclusions

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