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Erschienen in: CardioVasc 6/2017

12.12.2017 | Akute Pankreatitis | Fortbildung

Prognostische Kriterien für Ätiologie und Therapie

Hypertriglyzeridämie und HDL-Mangel

Erschienen in: CardioVasc | Ausgabe 6/2017

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Zusammenfassung

Mit steigenden Plasmakonzentrationen der Triglyzeride nehmen die Risiken für atherosklerotische Herz-Kreislauf-Erkrankungen (ASKVK) und akute Pankreatitis zu. Ein niedriger HDL-Cholesterin-Spiegel erhöht das ASKVK-Risiko. Bei moderater Hypertriglyzeridämie und niedrigem HDL-Cholesterin ist die Kontrolle anderer Risikofaktoren, insbe-sondere des LDL-Cholesterins, primäres Behandlungsziel. Bei Chylomikronämie ist die Senkung der Triglyzeride primäres Behandlungsziel.
Literatur
1.
Zurück zum Zitat Di Angelantonio E, Sarwar N, Perry P et al. Major lipids, apolipoproteins, and risk of vascular disease. JAMA. 2009;302(18):1993–2000CrossRefPubMed Di Angelantonio E, Sarwar N, Perry P et al. Major lipids, apolipoproteins, and risk of vascular disease. JAMA. 2009;302(18):1993–2000CrossRefPubMed
2.
Zurück zum Zitat Piepoli MF, Hoes AW, Agewall S et al. 2016 European Guidelines on cardiovascular disease prevention in clinical practice: The Sixth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of 10 societies and by invited experts) Developed with the special contribution of the European Association for Cardiovascular Prevention & Rehabilitation (EACPR). Atherosclerosis. 2016;252:207–74CrossRefPubMed Piepoli MF, Hoes AW, Agewall S et al. 2016 European Guidelines on cardiovascular disease prevention in clinical practice: The Sixth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of 10 societies and by invited experts) Developed with the special contribution of the European Association for Cardiovascular Prevention & Rehabilitation (EACPR). Atherosclerosis. 2016;252:207–74CrossRefPubMed
3.
Zurück zum Zitat Hegele RA, Ginsberg HN, Chapman MJ et al. The polygenic nature of hypertriglyceridaemia: implications for definition, diagnosis, and management. Lancet Diabetes Endocrinol. 2014;2(8):655–66CrossRefPubMed Hegele RA, Ginsberg HN, Chapman MJ et al. The polygenic nature of hypertriglyceridaemia: implications for definition, diagnosis, and management. Lancet Diabetes Endocrinol. 2014;2(8):655–66CrossRefPubMed
4.
Zurück zum Zitat Marz W, Kleber ME, Scharnagl H et al. HDL cholesterol: reappraisal of ist clinical relevance. Clin Res Cardiol. 2017 Mar 24. https://doi.org/10.1007/s00392-017-1106-1 Marz W, Kleber ME, Scharnagl H et al. HDL cholesterol: reappraisal of ist clinical relevance. Clin Res Cardiol. 2017 Mar 24. https://​doi.​org/​10.​1007/​s00392-017-1106-1
5.
Zurück zum Zitat von Eckardstein A, Rohrer L. HDLs in crises. Curr Opin Lipidol. 2016;27(3):264–73CrossRef von Eckardstein A, Rohrer L. HDLs in crises. Curr Opin Lipidol. 2016;27(3):264–73CrossRef
6.
Zurück zum Zitat Keene D, Price C, Shun-Shin MJ, Francis DP. Effect on cardiovascular risk of high density lipoprotein targeted drug treatments niacin, fibrates, and CETP inhibitors: meta-analysis of randomised controlled trials including 117,411 patients. BMJ. 2014;349:g4379. https://doi.org/10.1136/bmj.g4379.CrossRefPubMedPubMedCentral Keene D, Price C, Shun-Shin MJ, Francis DP. Effect on cardiovascular risk of high density lipoprotein targeted drug treatments niacin, fibrates, and CETP inhibitors: meta-analysis of randomised controlled trials including 117,411 patients. BMJ. 2014;349:g4379. https://​doi.​org/​10.​1136/​bmj.​g4379.​CrossRefPubMedPubMedCentral
7.
Zurück zum Zitat Lincoff AM, Nicholls SJ, Riesmeyer JS et al. Evacetrapib and Cardiovascular Outcomes in High-Risk Vascular Disease. N Engl J Med. 2017;376(20):1933–42CrossRefPubMed Lincoff AM, Nicholls SJ, Riesmeyer JS et al. Evacetrapib and Cardiovascular Outcomes in High-Risk Vascular Disease. N Engl J Med. 2017;376(20):1933–42CrossRefPubMed
8.
Zurück zum Zitat Bowman L, Hopewell JC, Chen F et al. Effects of Anacetrapib in Patients with Atherosclerotic Vascular Disease. N Engl J Med. 2017;377(13):1217–27CrossRefPubMed Bowman L, Hopewell JC, Chen F et al. Effects of Anacetrapib in Patients with Atherosclerotic Vascular Disease. N Engl J Med. 2017;377(13):1217–27CrossRefPubMed
9.
Zurück zum Zitat Ito MK. Long-chain omega-3 fatty acids, fibrates and niacin as therapeutic options in the treatment of hypertriglyceridemia: a review of the literature. Atherosclerosis. 2015;242(2):647–56CrossRefPubMed Ito MK. Long-chain omega-3 fatty acids, fibrates and niacin as therapeutic options in the treatment of hypertriglyceridemia: a review of the literature. Atherosclerosis. 2015;242(2):647–56CrossRefPubMed
10.
Zurück zum Zitat Schwartz GG, Olsson AG, Abt M et al. Effects of dalcetrapib in patients with a recent acute coronary syndrome. N Engl J Med. 2012;367(22):2089–99CrossRefPubMed Schwartz GG, Olsson AG, Abt M et al. Effects of dalcetrapib in patients with a recent acute coronary syndrome. N Engl J Med. 2012;367(22):2089–99CrossRefPubMed
11.
Zurück zum Zitat Pedersen SB, Langsted A, Nordestgaard BG. Nonfasting Mild-to-Moderate hypertriglyceridemia and Risk of Acute Pancreatitis. JAMA Intern Med. 2016;176(12):1834–42CrossRefPubMed Pedersen SB, Langsted A, Nordestgaard BG. Nonfasting Mild-to-Moderate hypertriglyceridemia and Risk of Acute Pancreatitis. JAMA Intern Med. 2016;176(12):1834–42CrossRefPubMed
12.
Zurück zum Zitat Nordestgaard BG. Triglyceride-Rich Lipoproteins and Atherosclerotic Cardiovascular Disease: New Insights From Epidemiology, Genetics, and Biology. Circ Res. 2016;118(4):547–63CrossRefPubMed Nordestgaard BG. Triglyceride-Rich Lipoproteins and Atherosclerotic Cardiovascular Disease: New Insights From Epidemiology, Genetics, and Biology. Circ Res. 2016;118(4):547–63CrossRefPubMed
13.
Zurück zum Zitat Jorgensen AB, Frikke-Schmidt R, West AS et al. Genetically elevated non-fasting triglycerides and calculated remnant cholesterol as causal risk factors for myocardial infarction. Eur Heart J. 2013;34(24):1826–33CrossRef Jorgensen AB, Frikke-Schmidt R, West AS et al. Genetically elevated non-fasting triglycerides and calculated remnant cholesterol as causal risk factors for myocardial infarction. Eur Heart J. 2013;34(24):1826–33CrossRef
14.
Zurück zum Zitat Expert Dyslipidemia Panel, Grundy SM. An International Atherosclerosis Society Position Paper: global recommendations for the management of dyslipidemia. J Clin Lipidol. 2013;7(6):561–5CrossRef Expert Dyslipidemia Panel, Grundy SM. An International Atherosclerosis Society Position Paper: global recommendations for the management of dyslipidemia. J Clin Lipidol. 2013;7(6):561–5CrossRef
15.
Zurück zum Zitat Sniderman AD, Toth PP, Thanassoulis G, Furberg CD. An evidence-based analysis of the National Lipid Association recommendations concerning non-HDL-C and apoB. J Clin Lipidol. 2016;10(5):1248–58CrossRefPubMed Sniderman AD, Toth PP, Thanassoulis G, Furberg CD. An evidence-based analysis of the National Lipid Association recommendations concerning non-HDL-C and apoB. J Clin Lipidol. 2016;10(5):1248–58CrossRefPubMed
16.
Zurück zum Zitat Nordestgaard BG, Langsted A, Mora S et al. Fasting Is Not Routinely Required for Determination of a Lipid Profile: Clinical and Laboratory Implications Including Flagging at Desirable Concentration Cutpoints-A Joint Consensus Statement from the European Atherosclerosis Society and European Federation of Clinical Chemistry and Laboratory Medicine. Clin Chem. 2016;62(7):930–46CrossRefPubMed Nordestgaard BG, Langsted A, Mora S et al. Fasting Is Not Routinely Required for Determination of a Lipid Profile: Clinical and Laboratory Implications Including Flagging at Desirable Concentration Cutpoints-A Joint Consensus Statement from the European Atherosclerosis Society and European Federation of Clinical Chemistry and Laboratory Medicine. Clin Chem. 2016;62(7):930–46CrossRefPubMed
17.
18.
Zurück zum Zitat Preiss D, Tikkanen MJ, Welsh P et al. Lipid-modifying therapies and risk of pancreatitis: a meta-analysis. JAMA. 2012;308(8):804–11CrossRefPubMed Preiss D, Tikkanen MJ, Welsh P et al. Lipid-modifying therapies and risk of pancreatitis: a meta-analysis. JAMA. 2012;308(8):804–11CrossRefPubMed
19.
Zurück zum Zitat Gaudet D, Alexander VJ, Baker BF et al. Antisense Inhibition of Apolipoprotein C-III in Patients with Hypertriglyceridemia. N Engl J Med. 2015;373(5):438–47CrossRefPubMed Gaudet D, Alexander VJ, Baker BF et al. Antisense Inhibition of Apolipoprotein C-III in Patients with Hypertriglyceridemia. N Engl J Med. 2015;373(5):438–47CrossRefPubMed
20.
Zurück zum Zitat Graham MJ, Lee RG, Brandt TA et al. Cardiovascular and Metabolic Effects of ANGPTL3 Antisense Oligonucleotides. N Engl J Med. 2017;377(3):222–32CrossRefPubMed Graham MJ, Lee RG, Brandt TA et al. Cardiovascular and Metabolic Effects of ANGPTL3 Antisense Oligonucleotides. N Engl J Med. 2017;377(3):222–32CrossRefPubMed
21.
Zurück zum Zitat Jorgensen AB, Frikke-Schmidt R, Nordestgaard BG, Tybjarg-Hansen A. Loss-of-function mutations in APOC3 and risk of ischemic vascular disease. N Engl J Med. 2014;371(1):32–41CrossRefPubMed Jorgensen AB, Frikke-Schmidt R, Nordestgaard BG, Tybjarg-Hansen A. Loss-of-function mutations in APOC3 and risk of ischemic vascular disease. N Engl J Med. 2014;371(1):32–41CrossRefPubMed
22.
Zurück zum Zitat Crosby J, Peloso GM, Auer PL et al. Loss-of-function mutations in APOC3, triglycerides, and coronary disease. N Engl J Med. 2014;371(1):22–31CrossRefPubMed Crosby J, Peloso GM, Auer PL et al. Loss-of-function mutations in APOC3, triglycerides, and coronary disease. N Engl J Med. 2014;371(1):22–31CrossRefPubMed
23.
Zurück zum Zitat Dewey FE, Gusarova V, Dunbar RL et al. Genetic and Pharmacologic Inactivation of ANGPTL3 and Cardiovascular Disease. N Engl J Med. 2017;377(3):211–21CrossRefPubMed Dewey FE, Gusarova V, Dunbar RL et al. Genetic and Pharmacologic Inactivation of ANGPTL3 and Cardiovascular Disease. N Engl J Med. 2017;377(3):211–21CrossRefPubMed
24.
Zurück zum Zitat Stitziel NO, Khera AV, Wang X et al. ANGPTL3 Deficiency and Protection Against Coronary Artery Disease. J Am Coll Cardiol. 2017;69(16):2054–63CrossRefPubMed Stitziel NO, Khera AV, Wang X et al. ANGPTL3 Deficiency and Protection Against Coronary Artery Disease. J Am Coll Cardiol. 2017;69(16):2054–63CrossRefPubMed
25.
Zurück zum Zitat Madsen CM, Varbo A, Nordestgaard BG. Extreme high high-density lipoprotein cholesterol is paradoxically associated with high mortality in men and women: two prospective cohort studies. Eur Heart J. 2017 Apr 12. https://doi.org/10.1093/eurheartj/ehx163 Madsen CM, Varbo A, Nordestgaard BG. Extreme high high-density lipoprotein cholesterol is paradoxically associated with high mortality in men and women: two prospective cohort studies. Eur Heart J. 2017 Apr 12. https://​doi.​org/​10.​1093/​eurheartj/​ehx163
26.
Zurück zum Zitat Bowe B, Xie Y, Xian H et al. High density lipoprotein cholesterol and the risk of all-cause mortality among US Veterans. Clin J Am Soc Nephrol. 2016;11(10):1784–93CrossRefPubMedPubMedCentral Bowe B, Xie Y, Xian H et al. High density lipoprotein cholesterol and the risk of all-cause mortality among US Veterans. Clin J Am Soc Nephrol. 2016;11(10):1784–93CrossRefPubMedPubMedCentral
27.
Zurück zum Zitat Ko DT, Alter DA, Guo H et al. High-Density Lipoprotein Cholesterol and Cause-Specific Mortality in Individuals Without Previous Cardiovascular Conditions: The CANHEART Study. J Am Coll Cardiol. 2016;68(19):2073–83CrossRefPubMed Ko DT, Alter DA, Guo H et al. High-Density Lipoprotein Cholesterol and Cause-Specific Mortality in Individuals Without Previous Cardiovascular Conditions: The CANHEART Study. J Am Coll Cardiol. 2016;68(19):2073–83CrossRefPubMed
28.
Zurück zum Zitat Madsen CM, Tybjaerg-Hanssen A, Nordestgaard BG. U-shaped relationship of high-density lipoprotein and risk of infectious disease: two prospective population-based cohort studies. Eur Heart J. 2017 in press Madsen CM, Tybjaerg-Hanssen A, Nordestgaard BG. U-shaped relationship of high-density lipoprotein and risk of infectious disease: two prospective population-based cohort studies. Eur Heart J. 2017 in press
29.
Zurück zum Zitat von Eckardstein A, Widmann C. High-density lipoprotein, beta cells, and diabetes. Cardiovasc Res. 2014;103(3):384–94CrossRef von Eckardstein A, Widmann C. High-density lipoprotein, beta cells, and diabetes. Cardiovasc Res. 2014;103(3):384–94CrossRef
30.
Zurück zum Zitat Fruchart JC, Davignon J, Hermans MP et al. Residual macrovascular risk in 2013: what have we learned? Cardiovasc Diabetol. 2014;13:26. https://doi.org/10.1186/1475-2840-13-26CrossRefPubMedPubMedCentral Fruchart JC, Davignon J, Hermans MP et al. Residual macrovascular risk in 2013: what have we learned? Cardiovasc Diabetol. 2014;13:26. https://​doi.​org/​10.​1186/​1475-2840-13-26CrossRefPubMedPubMedCentral
31.
Zurück zum Zitat Annema W, von Eckardstein A. High-density lipoproteins. Multifunctional but vulnerable protections from atherosclerosis. Circ J. 2013;77(10):2432–48CrossRefPubMed Annema W, von Eckardstein A. High-density lipoproteins. Multifunctional but vulnerable protections from atherosclerosis. Circ J. 2013;77(10):2432–48CrossRefPubMed
32.
Zurück zum Zitat Arai H, Yamashita S, Yokote K et al. Efficacy and safety of K-877, a novel selective peroxisome proliferator-activated receptor α modulator (SPPARMα), in combination with statin treatment: Two randomised, double-blind, placebo-controlled clinical trials in patients with dyslipidaemia. Atherosclerosis. 2017;261:144–52CrossRefPubMed Arai H, Yamashita S, Yokote K et al. Efficacy and safety of K-877, a novel selective peroxisome proliferator-activated receptor α modulator (SPPARMα), in combination with statin treatment: Two randomised, double-blind, placebo-controlled clinical trials in patients with dyslipidaemia. Atherosclerosis. 2017;261:144–52CrossRefPubMed
33.
Zurück zum Zitat West of Scotland Coronary Prevention Study Group Influence of pravastatin and plasma lipids on clinical events in the West of Scotland Coronary Prevention Study (WOSCOPS). Circulation. 1998;97(15):1440-5 West of Scotland Coronary Prevention Study Group Influence of pravastatin and plasma lipids on clinical events in the West of Scotland Coronary Prevention Study (WOSCOPS). Circulation. 1998;97(15):1440-5
34.
Zurück zum Zitat Ridker PM, Genest J, Boekholdt SM et al. HDL cholesterol and residual risk of first cardiovascular events after treatment with potent statin therapy: an analysis from the JUPITER trial. Lancet. 2010;376(9738):333–9CrossRefPubMed Ridker PM, Genest J, Boekholdt SM et al. HDL cholesterol and residual risk of first cardiovascular events after treatment with potent statin therapy: an analysis from the JUPITER trial. Lancet. 2010;376(9738):333–9CrossRefPubMed
35.
Zurück zum Zitat Sacks FM, Tonkin AM, Shepherd J et al. Effect of pravastatin on coronary disease events in subgroups defined by coronary risk factors: the Prospective Pravastatin Pooling Project. Circulation. 2000;102(16):1893–900CrossRefPubMed Sacks FM, Tonkin AM, Shepherd J et al. Effect of pravastatin on coronary disease events in subgroups defined by coronary risk factors: the Prospective Pravastatin Pooling Project. Circulation. 2000;102(16):1893–900CrossRefPubMed
36.
Zurück zum Zitat Barter P, Gotto AM, LaRosa JC et al. HDL cholesterol, very low levels of LDL cholesterol, and cardiovascular events. N Engl J Med. 2007;357(13):1301–10CrossRefPubMed Barter P, Gotto AM, LaRosa JC et al. HDL cholesterol, very low levels of LDL cholesterol, and cardiovascular events. N Engl J Med. 2007;357(13):1301–10CrossRefPubMed
37.
Zurück zum Zitat Ference BA, Kastelein JJP, Ginsberg HN et al. Association of Genetic Variants Related to CETP Inhibitors and Statins With Lipoprotein Levels and Cardiovascular Risk. JAMA. 2017;318(10):947–56CrossRefPubMed Ference BA, Kastelein JJP, Ginsberg HN et al. Association of Genetic Variants Related to CETP Inhibitors and Statins With Lipoprotein Levels and Cardiovascular Risk. JAMA. 2017;318(10):947–56CrossRefPubMed
38.
Zurück zum Zitat von Eckardstein A. Differential diagnosis of familial high density lipoprotein deficiency syndromes. Atherosclerosis. 2006;186(2):231–9 2017; 17 (6)CrossRef von Eckardstein A. Differential diagnosis of familial high density lipoprotein deficiency syndromes. Atherosclerosis. 2006;186(2):231–9 2017; 17 (6)CrossRef
Metadaten
Titel
Prognostische Kriterien für Ätiologie und Therapie
Hypertriglyzeridämie und HDL-Mangel
Publikationsdatum
12.12.2017
Erschienen in
CardioVasc / Ausgabe 6/2017
Print ISSN: 1617-4933
Elektronische ISSN: 1618-3851
DOI
https://doi.org/10.1007/s15027-017-1275-x

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