24.01.2022 | Nephrology - Original Paper
Hyperuricemia aggravates the progression of IgA nephropathy
verfasst von:
Yin-Hong Geng, Zhe Zhang, Jun-Jun Zhang, Bo Huang, Zui-Shuang Guo, Xu-Tong Wang, Lin-Qi Zhang, Song-Xia Quan, Rui-Min Hu, Ya-Fei Liu
Erschienen in:
International Urology and Nephrology
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Ausgabe 9/2022
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Abstract
Objective
The relationship between hyperuricemia and IgA nephropathy (IgAN) was evaluated systematically in this research.
Methods
The Preferred Reporting Items for Systematic Review and Meta-analysis statement was employed to design and report the study.
Results
Twenty-five studies were included in this meta-analysis with a total of 6048 IgAN patients. The clinical indicators indicated that blood urea nitrogen (BUN) (p < 0.00001, mean difference (MD) = 2.60, 95% confidence interval (CI) 1.74–3.46), serum creatinine (Scr) (p < 0.00001, MD = 44.56, 95% CI 31.15–57.98), diastolic blood pressure(DBP) (p < 0.00001, MD = 3.86, 95% CI 2.84–4.88), systolic blood pressure(SBP) (p < 0.00001, MD = 6.71, 95% CI 4.70–8.71), and 24-h urine protein(24 h TP) (p < 0.00001, MD = 0.76, 95% CI 0.58–0.94) were significantly increased in IgAN with hyperuricemia group than that in normouricemic IgAN group. The pathological analysis indicated that mesangial proliferation (p < 0.00001, MD = 0.12, 95% CI 0.07–0.17), vascular lesion (p < 0.00001, MD = 0.17, 95% CI 0.13–0.20), segmental lesion (p < 0.00001, MD = 0.15, 95% CI 0.03–0.26), tubulointerstitial damage (p < 0.00001, MD = 1.27, 95% CI 1.06–1.48), and glomerulosclerosis (p < 0.00001, MD = 0.56, 95% CI 0.40–0.72) were considerably climbed in IgAN patients with hyperuricemia compared without hyperuricemia group. Additionally, the estimated glomerular filtration rate (p < 0.00001, MD = − 29.03, 95% CI − 36.83 to − 21.23) was decreased in IgAN patients with hyperuricemia compared with normouricemic group.
Conclusion
Hyperuricemia exacerbates IgAN prognosis through aggravating the clinical outcomes and pathological results of IgAN.