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Erschienen in: Internal and Emergency Medicine 3/2019

15.02.2019 | IM - PHYSICAL EXAMINATION

Hypocalcemia and hypophosphatemia after treatment with zoledronic acid in a patient with AL amyloidosis

verfasst von: Antonella Tufano, Domenico Rendina, Paolo Conca, Beniamino Matani, Giovanni Di Minno

Erschienen in: Internal and Emergency Medicine | Ausgabe 3/2019

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Excerpt

Zoledronic acid (Zol) is the most powerful third generation aminobisphosphonate, can be intravenously (IV) administered, and is commonly used in patients with metabolic and neoplastic bone disorders, including multiple myeloma (MM). Zol reduces osteoclastic activity and promotes cellular apoptosis and can induce both hypocalcemia (HypoCa) and hypophosphatemia (HypoP), usually mild and asymptomatic. The risk of symptomatic severe HypoCa and HypoP, requiring specific treatment, is low, and has been described in patients with additional predisposing risk factors, such as low 25OHD3, chronic kidney disease (CKD), and/or liver damage [13]. …
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Metadaten
Titel
Hypocalcemia and hypophosphatemia after treatment with zoledronic acid in a patient with AL amyloidosis
verfasst von
Antonella Tufano
Domenico Rendina
Paolo Conca
Beniamino Matani
Giovanni Di Minno
Publikationsdatum
15.02.2019
Verlag
Springer International Publishing
Erschienen in
Internal and Emergency Medicine / Ausgabe 3/2019
Print ISSN: 1828-0447
Elektronische ISSN: 1970-9366
DOI
https://doi.org/10.1007/s11739-019-02048-w

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