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Cardiovascular Toxicology

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24.07.2020 | Sleep Apnea

Hypoxemia During Sleep and the Progression of Coronary Artery Calcium

verfasst von: Min Young Seo, Seung Hoon Lee, Sang Duk Hong, Seung-Kyu Chung, Hyo Yeol Kim

Erschienen in: Cardiovascular Toxicology | Ausgabe 1/2021

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Abstract

The aim of this study was to evaluate the associations between objective sleep parameters of obstructive sleep apnea (OSA) and progression of subclinical cardiovascular disease as measured by the coronary artery calcium (CAC) score. We reviewed the medical records of 196 patients who underwent both polysomnography (PSG) and repeated coronary artery computed tomography (CT) for screening purposes. For each participant, the first coronary CT scan was conducted within 12 months of PSG. Follow-up CT was performed voluntarily. The CAC score was log-transformed to obtain normally distributed data. We evaluated potential associations between various sleep parameters by analyzing overnight-attended PSG and CAC score progression over time. ST90 (total sleep time of SaO₂ < 90%), CT90 (percentage of time of SaO₂ < 90%), and degree of mean oxygen desaturation were significantly correlated with CAC score progression even after adjustment for confounders (age, sex, DM, HTN, hypercholesterolemia, BMI, and smoking status) (estimate = 0.004, p = .010; estimate = 0.009, p < .001; estimate = 0.027, p = .001; respectively). We also performed subgroup analysis and found that the progression of CAC score over time showed higher tendency when CT90 value was 2.73 or more (CT90 ≥ 2.73 group; estimate = 0.336, CT90 < 2.73 group; estimate = 0.194, p < .001 each). ST90, CT90 and mean oxygen desaturation are significant predictors of cardiovascular disease progression. Coronary artery status should be monitored repetitively in patients with hypoxemia during sleep.

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Titel: Hypoxemia During Sleep and the Progression of Coronary Artery Calcium
verfasst von: Min Young Seo
Seung Hoon Lee
Sang Duk Hong
Seung-Kyu Chung
Hyo Yeol Kim
Publikationsdatum: 24.07.2020
Verlag: Springer US
Schlagwörter: Sleep Apnea
Computed Tomography
Hypercholesterolemia
Computed Tomography
Hypoxemia
Polysomnography
Erschienen in: Cardiovascular Toxicology / Ausgabe 1/2021
Print ISSN: 1530-7905
Elektronische ISSN: 1559-0259
DOI: https://doi.org/10.1007/s12012-020-09593-3

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Hypoxemia During Sleep and the Progression of Coronary Artery Calcium

Abstract

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Abstract

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