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Erschienen in: Breast Cancer Research 2/2005

01.06.2005 | Poster Presentation

Hypoxia promotes invasion and metastasis of breast cancer cells by increasing lysyl oxidase expression

verfasst von: JT Erler, SS Jeffrey, AJ Giaccia

Erschienen in: Breast Cancer Research | Sonderheft 2/2005

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Excerpt

All solid tumors, including breast cancer, contain areas of low oxygen tension (hypoxia). Hypoxic cells are highly aggressive and metastatic, although the underlying processes remain unclear. We have found lysyl oxidase (LOX) expression to be increased by hypoxia in a variety of human cancer cell types. Lysyl oxidase (LOX) plays an essential role in the formation and maintenance of the extracellular matrix, and has previously been linked to increased in vitro invasion of breast cancer cells [1]. …
Literatur
1.
Zurück zum Zitat Kirschmann DA, et al: A molecular role for lysyl oxidase in breast cancer invasion. Cancer Res. 2002, 62: 4478-4483.PubMed Kirschmann DA, et al: A molecular role for lysyl oxidase in breast cancer invasion. Cancer Res. 2002, 62: 4478-4483.PubMed
2.
Zurück zum Zitat Sørlie T, et al: Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc Natl Acad Sci USA. 2001, 98: 10869-10874. 10.1073/pnas.191367098.CrossRefPubMedPubMedCentral Sørlie T, et al: Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc Natl Acad Sci USA. 2001, 98: 10869-10874. 10.1073/pnas.191367098.CrossRefPubMedPubMedCentral
3.
Zurück zum Zitat Zhao H, et al: Different gene expression patterns in invasive lobular and ductal carcinomas of the breast. Mol Biol Cell. 2004, 15: 2523-2536. 10.1091/mbc.E03-11-0786.CrossRefPubMedPubMedCentral Zhao H, et al: Different gene expression patterns in invasive lobular and ductal carcinomas of the breast. Mol Biol Cell. 2004, 15: 2523-2536. 10.1091/mbc.E03-11-0786.CrossRefPubMedPubMedCentral
Metadaten
Titel
Hypoxia promotes invasion and metastasis of breast cancer cells by increasing lysyl oxidase expression
verfasst von
JT Erler
SS Jeffrey
AJ Giaccia
Publikationsdatum
01.06.2005
Verlag
BioMed Central
Erschienen in
Breast Cancer Research / Ausgabe Sonderheft 2/2005
Elektronische ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr1186

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