Introduction
Materials and methods
Data resource
Identification of DEGs in HF
Functional enrichment analysis
Protein–protein interaction network construction and module screening
Target gene—miRNA regulatory network construction
Target gene—TF regulatory network construction
Receiver operating characteristic (ROC) curve analysis
RT-PCR analysis
Genes | Forward primers | Reverse primers |
---|---|---|
ESR1 | CCTCTGGCTACCATTATGGG | AGTCATTGTGTCCTTGAATGC |
PYHIN1 | GCAAGATCAGTACGACAGAG | AGATAACTGAGCAACCTGTG |
PPP2R2B | ACCAGAGACTATCTGACCG | GTAGTCATGAACCTGGTATGTC |
LCK | CTAGTCCGGCTTTATGCAG | AAATCTACTAGGCTCCCGT |
TP63 | ATTCAATGAGGGACAGATTGC | GGGTCTTCTACATACTGGGC |
PCLAF | GACCAATATAAACTGTGGCGGG | CCAGGGTAAACAAGGAGACGTT |
CFTR | CTGTGGCCTTGGTTTACTG | CTCTGATCTCTGTACTTCACCA |
TK1 | AGATTCAGGTGATTCTCGGG | ACTTGTACTGGGCGATCTG |
ECT2 | GCTGTATTGTACGAGTATGCT | GTCACCAATTTGACAAGCTC |
FKBP5 | CCTAAGTTTGGCATTGACCC | CCAAGATTCTTTGGCCTTCTC |
Identification of candidate small molecules
Results
Identification of DEGs in HF
Functional enrichment analysis
GO ID | CATEGORY | GO Name | P Value | FDR B&H | FDR B&Y | Bonferroni | Gene Count | Gene |
---|---|---|---|---|---|---|---|---|
Up regulated genes | ||||||||
GO:0022610 | BP | biological adhesion | 1.32E−13 | 3.37E−10 | 3.08E−09 | 6.75E−10 | 72 | HLA-DQA1, DACT2, CD83, MDK, UBASH3A, ITGBL1, FAP, MFAP4, SERPINE2, NRXN2, COL14A1, CCR7, ALOX15, COL1A1, LAMB4, COL8A2, STAB2, COL16A1, COMP, TBX21, FERMT1, XG, CCDC80, APOA1, PODXL2, ZAP70, HAPLN1, TENM4, SKAP1, CNTNAP2, PDE5A, CARD11, CTNNA2, SLAMF7, ATP1B2, CX3CR1, LRRC15, IDO1, MYOC, SIGLEC8, ISLR, SMOC2, ITGAL, ITGB7, FREM1, PTN, KIRREL3, NTM, GLI2, FBLN7, DPT, NT5E, ECM2, LCK, OMG, OPCML, TGFB2, RASGRP1, CD2, CD3E, THBS4, CD5, CD6, THY1, TIGIT, CD27, CD40LG, ROBO2, GREM1, LY9, HBB, LEF1 |
GO:0002682 | BP | regulation of immune system process | 2.20E−10 | 2.25E−07 | 2.05E−06 | 1.12E−06 | 72 | IL34, HLA-DQA1, ESR1, TLR7, CD83, IL17D, MDK, UBASH3A, TNFRSF4, PYHIN1, ZBP1, FCER1A, MS4A2, FCER2, FCN1, CCR7, SMPD3, CCL24, SCARA3, ALOX15, COL1A1, IL31RA, TBX21, XG, CXCL14, APOA1, ZAP70, SH2D1B, SKAP1, PDE5A, CARD11, SLAMF7, CTSG, CX3CR1, IDO1, CXCL10, ITGAL, ACE, SIT1, ITGB7, PTN, TBC1D10C, FCRL3, BPI, GLI2, KLRB1, NPPA, CAMK4, LCK, TGFB2, RASGRP1, CD1C, CD1E, CD2, CD3D, CD3E, THBS4, CD3G, CD247, CD5, CD6, THY1, TIGIT, MS4A1, CD27, GPR68, CD40LG, CD48, GREM1, SH2D1A, LEF1, LRRC17 |
GO:0031012 | CC | extracellular matrix | 1.09E−20 | 2.77E−18 | 1.89E−17 | 5.54E−18 | 52 | MATN2, COL22A1, MDK, COLQ, MFAP4, SERPINE2, HMCN2, AEBP1, FCN1, CMA1, CTHRC1, COL14A1, SCARA3, COL1A1, LAMB4, COL8A2, COL9A1, COL9A2, COL10A1, MXRA5, FMOD, COL16A1, COMP, CCDC80, APOA1, HAPLN1, CTSG, ADAMTSL2, LRRC15, ASPN, MYOC, NDP, SMOC2, FREM1, PTN, SSC5D, SULF1, DPT, NPPA, ADAMTSL1, ECM2, OGN, ITIH5, TGFB2, LEFTY2, EYS, THBS4, P3H2, LTBP2, GREM1, LUM, LRRC17 |
GO:0009986 | CC | cell surface | 5.07E−17 | 8.61E−15 | 5.86E−14 | 2.58E−14 | 63 | HYAL4, NRG1, HLA-DQA1, CD83, TNFRSF4, ITGBL1, FAP, SERPINE2, FCER1A, MS4A2, FCER2, FCN1, CXCL9, CCR7, IL31RA, SFRP4, STAB2, DUOX2, APOA1, ACKR4, FCRL6, SCUBE2, CNTNAP2, SLAMF7, CTSG, IL2RB, CX3CR1, LRRC15, CXCL10, NDP, ITGAL, ACE, ITGB7, GFRA3, PTN, PROM1, SSC5D, FCRL3, SULF1, MRC2, NTM, CLEC9A, NT5E, TGFB2, LHCGR, CD1C, HHIP, CD1E, CD2, CD3D, CD3E, CD3G, CD5, CD6, THY1, TIGIT, MS4A1, CD27, CD40LG, CD48, ROBO2, GREM1, LY9 |
GO:0005102 | MF | signaling receptor binding | 1.36E−09 | 5.99E−07 | 4.41E−06 | 1.20E−06 | 73 | IL34, NRG1, HLA-DQA1, ESR1, GDF6, PENK, TAC4, KDM5D, IL17D, MDK, ITGBL1, FAP, SERPINE2, FCER2, NRXN2, FCN1, CLEC11A, UCHL1, AGTR2, CXCL9, NGEF, CTHRC1, C1QTNF2, CCL22, CCL24, CXCL11, COL16A1, COMP, WNT10B, WNT9A, CXCL14, APOA1, FCRL6, GNA14, OASL, RASL11B, LRRC15, CXCL10, ADAM18, MYOC, SYTL2, NDP, ACE, GDNF, ITGB7, GFRA3, PTN, LYPD1, SCG2, NPPA, NPPB, MCHR1, ECM2, CMTM2, ESM1, LCK, OGN, TGFB2, LEFTY2, CD2, CD3E, THBS4, CD3G, THY1, TIGIT, MS4A1, C1QTNF9, CD40LG, LTB, GREM1, SYTL1, LEF1, LGI1 |
GO:0098772 | MF | molecular function regulator | 3.79E−04 | 1.59E−02 | 1.17E−01 | 3.34E−01 | 58 | IL34, NRG1, ESR1, GDF6, PENK, TAC4, IL17D, MDK, KCNIP1, SERPINE2, MYOZ1, NRXN2, CLEC11A, SCN2B, AGTR2, CXCL9, NGEF, CCL22, CCL24, CXCL11, HTR2B, PI16, SCG5, WNT10B, WNT9A, CXCL14, APOA1, LRRC55, PPP2R2B, ATP1B2, CXCL10, NDP, BIRC7, GDNF, PTN, TBC1D10C, LYPD1, SCG2, NPPA, NPPB, AZIN2, CMTM2, OGN, RGS4, ITIH5, TGFB2, LEFTY2, RASGRP1, THBS4, THY1, CD27, C1QTNF9, CD40LG, RGS17, LTB, GREM1, LEF1, INKA1 |
Down regulated genes | ||||||||
GO:0046903 | BP | secretion | 1.07E−11 | 5.64E−08 | 5.16E−07 | 5.64E−08 | 78 | SERPINA3, HK3, SYN3, ACP3, TRPC4, CFTR, CD109, HMOX2, CHI3L1, F5, F8, F13A1, S100A8, S100A9, SAA1, FCER1G, MGST1, PIK3C2A, HP, AGTR1, PLA2G2A, CCR1, FGF10, C1QTNF1, PLA2G4F, FGR, MERTK, SERPINF2, ALOX5, SYT13, IL17RB, CNR1, ALOX15B, FLT3, ANPEP, P2RY12, ANXA3, FPR1, CR1, SLC1A1, SLC2A1, ARG1, ARNTL, SLC11A1, SLC22A16, LGI3, NSG1, ATP2A2, IL10, SIGLEC9, GPR84, NHLRC2, SSTR5, HPSE, KCNB1, IL1R2, PTX3, GLUL, SYN2, BANK1, WNK3, KNG1, CRISPLD2, CACNA1E, CD177, SIGLEC14, EDN1, EDN2, EDNRB, THBS1, RNASE2, CD38, TLR2, SERPINE1, ELANE, STEAP3, IL1RL1, MCEMP1 |
GO:0006952 | BP | defense response | 1.04E−06 | 1.63E−04 | 1.49E−03 | 5.50E−03 | 65 | SERPINA3, EREG, VSIG4, TMIGD3, CLEC7A, RAET1E, CHI3L1, F8, CD163, S100A8, S100A9, SAA1, FCER1G, HP, HPR, AGTR1, PLA2G2A, CCR1, FGR, SERPINF2, ALOX5, ALOX5AP, IL17RB, CNR1, SELE, ADAMTS4, ANXA3, FPR1, APOB, SAMHD1, CR1, FCN3, AQP4, ARG1, SLC11A1, MARCO, IL10, BCL6, IL18R1, GGT5, IL1R2, PTX3, SIGLEC10, KNG1, CACNA1E, CD177, SOCS3, SIGLEC14, ADAMTS5, LBP, S1PR3, EDN1, EDNRB, FOSL1, THBS1, RNASE2, NAMPT, TLR2, SERPINE1, ELANE, IRAK3, ELF3, IL1RL1, CALCRL, OSMR |
GO:0031226 | CC | intrinsic component of plasma membrane | 1.74E−10 | 4.55E−08 | 3.11E−07 | 9.10E−08 | 74 | TPO, EREG, OPN4, TRPC4, CFTR, TMIGD3, KCNIP2, CD163, FCER1G, SCN3A, AGTR1, CCR1, C1QTNF1, MERTK, SYT13, IL17RB, CNR1, TRHDE, SELE, LRRC8E, FLT3, SLC4A7, P2RY12, SLC31A2, CR1, LGR5, AQP3, AQP4, SLC1A1, SLC2A1, SLC5A1, MSR1, SLC11A1, SIGLEC7, ART3, SLCO2A1, ATP2A2, MARCO, GABRR2, SIGLEC9, SLCO4A1, GPR84, SSTR2, SSTR5, IL18R1, LAPTM5, GGT5, SLC52A3, LYVE1, KCNA7, KCNB1, KCND3, NECTIN1, KCNK1, KCNK3, KCNS2, ADGRD1, CACNA1E, GPR4, GPR12, SLC38A4, GPR183, GPRC5A, RGR, S1PR3, RHAG, EDNRB, TGFBR3, TLR2, LGR6, CALCRL, OSMR, HAS2, CDH16 |
GO:0098805 | CC | whole membrane | 1.91E−03 | 4.99E−02 | 3.41E−01 | 9.97E−01 | 51 | EREG, SYN3, ACP3, TRPC4, CFTR, CD109, HMOX2, CD163, FCER1G, MGST1, PLA2G4F, GPAT2, MOG, CNR1, SELE, ANPEP, P2RY12, ANXA3, FPR1, APOB, SCGN, CR1, AQP4, SLC1A1, SLC2A1, ARG1, MSR1, SLC11A1, NSG1, RAB39A, MARCO, SIGLEC9, GPR84, HPSE, LAPTM5, KCND3, SYN2, SLC9A7, WASF1, CD177, SIGLEC14, GRB14, STEAP4, EDNRB, GRIP1, CD38, TLR2, STEAP3, HAS2, SERPINA5, MCEMP1 |
GO:0038023 | MF | signaling receptor activity | 2.36E−04 | 1.97E−02 | 1.49E−01 | 2.53E−01 | 55 | EREG, OPN4, CLEC7A, FCER1G, FCGR3A, AGTR1, CCR1, ADGRF5, ADGRF4, MERTK, IL17RB, CNR1, SELE, FLT3, MYOT, ANPEP, P2RY12, ANXA3, FPR1, CR1, LGR5, SIGLEC7, MARCO, PALLD, IL10, GABRR2, IL15RA, GPR82, DNER, PAQR5, GPR84, IL20RA, SSTR2, SSTR5, IL18R1, LYVE1, IL1R2, NECTIN1, ADGRD1, GPR4, GPR12, NPTX2, GPR183, GPRC5A, PKHD1L1, RGR, S1PR3, EDNRB, TGFBR3, TLR2, SERPINE1, IL1RL1, LGR6, CALCRL, OSMR |
GO:0060089 | MF | molecular transducer activity | 4.71E−04 | 2.10E−02 | 1.59E−01 | 5.04E−01 | 58 | EREG, OPN4, CLEC7A, FCER1G, FCGR3A, AGTR1, CCR1, ADGRF5, ADGRF4, MERTK, IL17RB, CNR1, SELE, FLT3, MYOT, ANPEP, P2RY12, ANXA3, FPR1, CR1, LGR5, SIGLEC7, MARCO, PALLD, IL10, GABRR2, IL15RA, GPR82, DNER, PAQR5, GPR84, IL20RA, STOX1, SSTR2, SSTR5, IL18R1, BLM, CDKL5, LYVE1, IL1R2, NECTIN1, ADGRD1, GPR4, GPR12, NPTX2, GPR183, GPRC5A, PKHD1L1, RGR, S1PR3, EDNRB, TGFBR3, TLR2, SERPINE1, IL1RL1, LGR6, CALCRL, OSMR |
Pathway ID | Pathway name | P-value | FDR B&H | FDR B&Y | Bonferroni | Gene count | Gene |
---|---|---|---|---|---|---|---|
Up regulated genes | |||||||
1270244 | Extracellular matrix organization | 3.33E−08 | 1.80E−05 | 1.23E−04 | 1.80E−05 | 24 | COL22A1, MFAP4, CMA1, COL14A1, COL1A1, COL8A2, COL9A1, COL9A2, COL10A1, FMOD, COL16A1, COMP, HAPLN1, ADAMTS14, CTSG, ASPN, ITGAL, ITGB7, CAPN6, TGFB2, P3H2, TLL2, LTBP2, LUM |
1269201 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 8.13E−06 | 7.31E−04 | 5.03E−03 | 4.39E−03 | 13 | SH2D1B, SLAMF7, SIGLEC8, ITGAL, ITGB7, KLRB1, CD1C, CD3D, CD3E, CD3G, CD247, CD40LG, SH2D1A |
1269544 | GPCR ligand binding | 3.92E−04 | 1.51E−02 | 1.04E−01 | 2.12E−01 | 22 | GNG8, PENK, F2RL2, AGTR2, APLNR, CXCL9, CCR7, CXCL11, OXER1, HTR2A, HTR2B, WNT10B, WNT9A, ACKR4, CRHBP, S1PR5, FZD2, CX3CR1, CXCL10, MCHR1, LHCGR, GPR68 |
1268749 | Metabolism of Angiotensinogen to Angiotensins | 5.26E−04 | 1.85E−02 | 1.27E−01 | 2.84E−01 | 4 | CMA1, CTSG, ACE, GZMH |
1269868 | Muscle contraction | 3.44E−02 | 4.03E−01 | 1.00E+00 | 1.00E+00 | 9 | KCNIP1, RYR3, SCN2B, ATP1A4, ATP1B2, MYL1, KCNK17, NPPA, TNNI1 |
1269340 | Hemostasis | 6.57E−02 | 5.21E−01 | 1.00E+00 | 1.00E+00 | 20 | GNG8, CEACAM3, F2RL2, SERPINE2, APOA1, GNA14, PDE5A, ATP1B2, IL2RB, CTSW, ISLR, ITGAL, LCK, TGFB2, LEFTY2, RASGRP1, CD2, P2RX6, CD48, HBB |
1269171 | Adaptive Immune System | 1.32E−01 | 6.87E−01 | 1.00E+00 | 1.00E+00 | 23 | NRG1, HLA-DQA1, ZAP70, SH2D1B, CARD11, SLAMF7, SIGLEC8, ITGAL, ITGB7, ASB18, IER3, MRC2, KLRB1, LCK, RASGRP1, CD1C, CD3D, CD3E, CD3G, CD247, FBXL16, CD40LG, SH2D1A |
Down regulated genes | |||||||
1457780 | Neutrophil degranulation | 4.82E−06 | 3.14E−03 | 2.22E−02 | 3.14E−03 | 28 | SERPINA3, HK3, ACP3, HMOX2, CHI3L1, S100A8, S100A9, FCER1G, MGST1, HP, FGR, ALOX5, ANPEP, FPR1, CR1, ARG1, SLC11A1, SIGLEC9, GPR84, HPSE, PTX3, CRISPLD2, CD177, SIGLEC14, RNASE2, TLR2, ELANE, MCEMP1 |
1269907 | SLC-mediated transmembrane transport | 6.91E−04 | 4.74E−02 | 3.35E−01 | 4.51E−01 | 16 | HK3, SLC7A11, SLC4A7, SLC1A1, SLC2A1, SLC5A1, SLC11A1, SLC22A16, SLCO2A1, SLCO4A1, GCKR, LCN15, SLC9A7, SLC25A18, SLC38A4, RHAG |
1269545 | Class A/1 (Rhodopsin-like receptors) | 8.72E−04 | 4.74E−02 | 3.35E−01 | 5.69E−01 | 17 | OPN4, SAA1, AGTR1, CCR1, CNR1, P2RY12, FPR1, SSTR2, SSTR5, KNG1, GPR4, GPR183, RGR, S1PR3, EDN1, EDN2, EDNRB |
1269340 | Hemostasis | 2.18E−03 | 7.11E−02 | 5.02E−01 | 1.00E+00 | 26 | SERPINA3, CD109, SLC7A11, F5, F8, F13A1, SERPINB8, FCER1G, FGR, MERTK, SERPINF2, SELE, P2RY12, APOB, KIF18B, ATP2A2, NHLRC2, KNG1, PDE11A, CD177, DOCK9, GRB7, GRB14, THBS1, SERPINE1, SERPINA5 |
1269903 | Transmembranetransport of small molecules | 4.89E−03 | 1.28E−01 | 9.01E−01 | 1.00E+00 | 26 | HK3, TRPC4, CFTR, HMOX2, SLC7A11, ABCB1, SLC4A7, AQP3, AQP4, SLC1A1, SLC2A1, SLC5A1, SLC11A1, SLC22A16, SLCO2A1, ATP2A2, GABRR2, SLCO4A1, GCKR, LCN15, SLC9A7, WNK3, SLC25A18, SLC38A4, RHAG, STEAP3 |
1269203 | Innate Immune System | 9.62E−03 | 1.96E−01 | 1.00E+00 | 1.00E+00 | 42 | SERPINA3, EREG, HK3, MARK3, ACP3, CLEC7A, HMOX2, CHI3L1, S100A8, S100A9, SAA1, FCER1G, MGST1, FCGR3A, HP, GRAP2, PLA2G2A, FGF5, FGF10, FGR, ALOX5, ANPEP, FPR1, APOB, CR1, FCN3, ARG1, SLC11A1, SIGLEC9, GPR84, HPSE, PTX3, WASF1, CRISPLD2, CD177, SIGLEC14, LBP, RNASE2, TLR2, ELANE, IRAK3, MCEMP1 |
1269310 | Cytokine Signaling in Immune system | 8.42E−02 | 4.76E−01 | 1.00E+00 | 1.00E+00 | 23 | EREG, MARK3, F13A1, SAA1, FGF5, CCR1, FGF10, ALOX5, IL17RB, FLT3, FPR1, SAMHD1, IL10, IL15RA, IL20RA, BCL6, IL18R1, IL1R2, SOCS3, LBP, IRAK3, IL1RL1, OSMR |
Protein–protein interaction (PPI) network and module analysis
Regulation | Node | Degree | Betweenness | Stress | Closeness |
---|---|---|---|---|---|
Up | ESR1 | 1094 | 0.250896 | 7.4E+08 | 0.392769 |
Up | PYHIN1 | 342 | 0.054258 | 1.1E+08 | 0.339882 |
Up | PPP2R2B | 199 | 0.023115 | 35,268,762 | 0.346839 |
Up | LCK | 162 | 0.033618 | 18,589,354 | 0.353915 |
Up | TP63 | 142 | 0.018577 | 39,426,608 | 0.319664 |
Up | CD247 | 129 | 0.013832 | 18,625,274 | 0.317784 |
Up | PTN | 105 | 0.016638 | 36,892,166 | 0.300662 |
Up | APLNR | 103 | 0.016611 | 40,715,208 | 0.288093 |
Up | APOA1 | 100 | 0.018834 | 13,935,332 | 0.315866 |
Up | CENPA | 98 | 0.009846 | 31,131,318 | 0.301786 |
Up | SKAP1 | 97 | 0.01599 | 10,109,482 | 0.313338 |
Up | FSCN1 | 88 | 0.010226 | 9,387,016 | 0.335367 |
Up | SCN2B | 86 | 0.01089 | 24,233,242 | 0.284756 |
Up | TMEM30B | 79 | 0.016411 | 10,490,230 | 0.270807 |
Up | FOXS1 | 79 | 0.009408 | 26,398,078 | 0.293247 |
Up | COL1A1 | 76 | 0.010472 | 9,315,670 | 0.308098 |
Up | ZAP70 | 75 | 0.007096 | 5,315,196 | 0.317614 |
Up | UCHL1 | 74 | 0.009753 | 9,381,024 | 0.331525 |
Up | HBB | 72 | 0.009984 | 14,209,592 | 0.304767 |
Up | NRG1 | 70 | 0.01151 | 13,449,066 | 0.29526 |
Up | LEF1 | 61 | 0.007998 | 18,260,094 | 0.290744 |
Up | NT5E | 60 | 0.009599 | 11,470,634 | 0.301563 |
Up | MDK | 59 | 0.006889 | 7,533,352 | 0.305822 |
Up | ISLR | 58 | 0.010139 | 9,992,806 | 0.294012 |
Up | FATE1 | 57 | 0.011609 | 9,248,788 | 0.281581 |
Up | LRRC15 | 56 | 0.010069 | 4,772,792 | 0.299094 |
Up | MATN2 | 54 | 0.004491 | 9,580,600 | 0.286792 |
Up | LIPH | 54 | 0.008197 | 6,873,658 | 0.282347 |
Up | MYOC | 49 | 0.005138 | 12,313,276 | 0.291029 |
Up | SCARA3 | 49 | 0.006492 | 11,494,220 | 0.290151 |
Up | NPPA | 46 | 0.009502 | 4,868,574 | 0.307143 |
Up | CD83 | 43 | 0.005149 | 5,484,906 | 0.272841 |
Up | COL14A1 | 41 | 0.006129 | 5,699,128 | 0.292893 |
Up | CTSG | 40 | 0.003821 | 1,913,996 | 0.296155 |
Up | SFRP4 | 40 | 0.004006 | 7,876,966 | 0.282518 |
Up | TRAF3IP3 | 38 | 0.006447 | 4,263,002 | 0.290602 |
Up | CLEC11A | 38 | 0.005085 | 3,520,012 | 0.283596 |
Up | ATP1B4 | 38 | 0.005722 | 2,476,482 | 0.245939 |
Up | CD3E | 37 | 0.003892 | 1,537,326 | 0.297624 |
Up | SH2D1A | 37 | 0.003969 | 2,117,220 | 0.308113 |
Up | DDX3Y | 37 | 0.003754 | 1,632,916 | 0.32095 |
Up | PRPH | 37 | 0.001871 | 1,994,266 | 0.301494 |
Up | BIRC7 | 35 | 0.004835 | 2,567,254 | 0.28549 |
Up | CARD11 | 35 | 0.002249 | 2,510,852 | 0.292173 |
Up | RXRG | 35 | 0.002394 | 7,134,478 | 0.26225 |
Up | CCL22 | 34 | 0.005706 | 3,916,024 | 0.281423 |
Up | CD27 | 33 | 0.003915 | 2,076,446 | 0.294263 |
Up | GZMB | 32 | 0.003277 | 6,141,522 | 0.285602 |
Up | THY1 | 32 | 0.003561 | 1,793,684 | 0.291509 |
Up | CHRNA3 | 32 | 0.004247 | 3,415,720 | 0.236631 |
Up | LSP1 | 32 | 0.003371 | 5,734,010 | 0.281836 |
Up | IL2RB | 31 | 0.002351 | 1,938,172 | 0.305808 |
Up | HTR2B | 30 | 0.004018 | 2,165,998 | 0.27434 |
Up | DLGAP1 | 29 | 0.003816 | 6,072,882 | 0.277754 |
Up | TRIM17 | 29 | 0.002943 | 5,543,810 | 0.275137 |
Up | CTNNA2 | 29 | 0.003554 | 3,511,510 | 0.30254 |
Up | SERPINE2 | 28 | 0.002577 | 3,031,536 | 0.27426 |
Up | CD1E | 28 | 0.003282 | 3,419,392 | 0.255229 |
Up | MRC2 | 28 | 0.003395 | 2,950,548 | 0.296276 |
Up | C1QTNF2 | 28 | 0.003203 | 2,505,388 | 0.270147 |
Up | SH2D1B | 27 | 0.001864 | 1,043,570 | 0.29028 |
Up | BRINP1 | 27 | 0.001516 | 4,402,948 | 0.27726 |
Up | PDIA2 | 27 | 0.001967 | 2,895,182 | 0.286453 |
Up | CHD5 | 27 | 0.001918 | 5,223,636 | 0.286503 |
Up | FAP | 27 | 0.003531 | 5,820,086 | 0.268583 |
Up | IL31RA | 26 | 0.002073 | 1,606,954 | 0.263603 |
Up | GAP43 | 25 | 0.002745 | 2,793,268 | 0.279858 |
Up | CD5 | 25 | 0.001695 | 655,904 | 0.295861 |
Up | UBASH3A | 25 | 0.001652 | 1,347,264 | 0.290951 |
Up | ROBO2 | 25 | 0.002959 | 3,726,616 | 0.267048 |
Up | ITGB7 | 24 | 0.002686 | 3,351,660 | 0.276124 |
Up | HTR2A | 24 | 0.002571 | 2,472,010 | 0.275833 |
Up | MOXD1 | 24 | 0.002391 | 2,492,756 | 0.259926 |
Up | ASB18 | 24 | 9.77E−04 | 3,202,162 | 0.273001 |
Up | CD2 | 23 | 0.002221 | 926,408 | 0.287954 |
Up | BCL11B | 23 | 8.18E−04 | 1,888,298 | 0.28836 |
Up | STAT4 | 23 | 0.001786 | 2,435,506 | 0.277166 |
Up | NGEF | 23 | 0.001809 | 1,548,206 | 0.277636 |
Up | SMPD3 | 23 | 0.002518 | 2,175,774 | 0.281 |
Up | FZD2 | 22 | 0.003673 | 3,239,390 | 0.250335 |
Up | DUSP15 | 22 | 0.001253 | 2,474,532 | 0.284472 |
Up | CD3D | 21 | 0.001725 | 1,111,132 | 0.288589 |
Up | SYT17 | 21 | 0.002549 | 2,482,574 | 0.285802 |
Up | FCGR3B | 21 | 0.002748 | 1,492,022 | 0.282286 |
Up | EGR2 | 21 | 0.002934 | 3,438,856 | 0.266406 |
Up | ZBP1 | 21 | 0.001876 | 2,664,938 | 0.26006 |
Up | CAMK4 | 21 | 0.001773 | 3,472,134 | 0.272716 |
Up | DMC1 | 20 | 0.002511 | 4,659,098 | 0.254277 |
Up | GDNF | 20 | 0.002515 | 3,274,958 | 0.244751 |
Up | FCN1 | 20 | 0.002571 | 1,243,380 | 0.236742 |
Up | LUM | 20 | 0.002276 | 1,515,870 | 0.283903 |
Up | GZMA | 20 | 0.001051 | 3,258,230 | 0.276498 |
Up | TGFB2 | 20 | 0.002259 | 1,632,566 | 0.277119 |
Up | SLAMF7 | 20 | 0.00211 | 1,035,482 | 0.271708 |
Up | MS4A1 | 20 | 0.002857 | 1,169,078 | 0.288398 |
Up | ETV4 | 20 | 0.001747 | 1,674,080 | 0.301883 |
Up | GLI2 | 20 | 0.001398 | 2,977,194 | 0.285902 |
Up | PHLDA1 | 19 | 4.37E−04 | 818,256 | 0.298194 |
Up | COL8A2 | 19 | 0.00147 | 1,089,762 | 0.273835 |
Up | GABRD | 19 | 0.002826 | 2,629,544 | 0.25748 |
Up | LMF1 | 19 | 0.004342 | 2,024,228 | 0.265132 |
Up | F2RL2 | 19 | 0.001554 | 790,338 | 0.282933 |
Up | LYPD1 | 19 | 0.003123 | 3,995,458 | 0.266276 |
Up | CAPN6 | 19 | 0.001415 | 3,046,736 | 0.267802 |
Up | SOX8 | 19 | 0.003361 | 2,763,024 | 0.251306 |
Up | IER3 | 18 | 0.001921 | 3,613,164 | 0.282982 |
Up | BEX1 | 18 | 0.001034 | 1,286,206 | 0.273606 |
Up | COLQ | 18 | 0.001173 | 1,414,826 | 0.261234 |
Up | NTM | 18 | 0.00284 | 2,486,684 | 0.275102 |
Up | RPS4Y1 | 18 | 0.001013 | 1,200,768 | 0.287713 |
Up | FERMT1 | 18 | 0.001713 | 4,279,868 | 0.270315 |
Up | RGS17 | 18 | 0.002928 | 3,868,106 | 0.249895 |
Up | TNNI1 | 17 | 0.001349 | 1,550,004 | 0.266765 |
Up | MYOZ1 | 17 | 0.00128 | 2,111,156 | 0.283203 |
Up | KLHDC8A | 17 | 0.001147 | 7,007,508 | 0.251036 |
Up | MYL1 | 17 | 7.90E−04 | 1,213,666 | 0.289945 |
Up | DIO2 | 16 | 0.001161 | 1,959,228 | 0.279416 |
Up | ITGAL | 16 | 0.001182 | 1,521,116 | 0.271527 |
Up | CRABP2 | 16 | 4.13E−04 | 675,182 | 0.272171 |
Up | HSH2D | 16 | 0.001425 | 889,856 | 0.26034 |
Up | CD48 | 3 | 0 | 0 | 0.265422 |
Up | CD3G | 2 | 0 | 0 | 0.23833 |
Up | LY9 | 2 | 0 | 0 | 0.240141 |
Up | SIT1 | 2 | 0 | 0 | 0.264221 |
Up | ATP1A4 | 2 | 1.16E−04 | 79,140 | 0.235049 |
Up | FMOD | 2 | 3.96E−05 | 20,526 | 0.240707 |
Up | CCDC80 | 2 | 3.58E−05 | 499,704 | 0.288908 |
Up | CCR7 | 2 | 0 | 0 | 0.244312 |
Up | KCNIP1 | 1 | 0 | 0 | 0.219995 |
Up | CD6 | 1 | 0 | 0 | 0.22832 |
Up | FCRL3 | 1 | 0 | 0 | 0.241062 |
Up | SERTAD4 | 1 | 0 | 0 | 0.257531 |
Up | PRF1 | 1 | 0 | 0 | 0.222162 |
Up | C1QTNF9 | 1 | 0 | 0 | 0.226548 |
Up | OPCML | 1 | 0 | 0 | 0.215756 |
Up | ESM1 | 1 | 0 | 0 | 0.213551 |
Up | CD40LG | 1 | 0 | 0 | 0.240053 |
Up | S1PR5 | 1 | 0 | 0 | 0.24224 |
Up | AGTR2 | 1 | 0 | 0 | 0.259256 |
Up | NPPB | 1 | 0 | 0 | 0.211726 |
Up | SCG5 | 1 | 0 | 0 | 0.238721 |
Up | PDE5A | 1 | 0 | 0 | 0.243548 |
Up | RYR3 | 1 | 0 | 0 | 0.274755 |
Up | RASEF | 1 | 0 | 0 | 0.274755 |
Up | PODXL2 | 1 | 0 | 0 | 0.213106 |
Up | OGN | 1 | 0 | 0 | 0.226548 |
Up | PLCH2 | 1 | 0 | 0 | 0.238721 |
Up | SCG2 | 1 | 0 | 0 | 0.267704 |
Up | P3H2 | 1 | 0 | 0 | 0.207132 |
Up | C12orf75 | 1 | 0 | 0 | 0.217608 |
Up | ACE | 1 | 0 | 0 | 0.241159 |
Up | GNA14 | 1 | 0 | 0 | 0.217608 |
Up | HDC | 1 | 0 | 0 | 0.216614 |
Up | CMA1 | 1 | 0 | 0 | 0.226713 |
Up | CEACAM3 | 1 | 0 | 0 | 0.265519 |
Down | PCLAF | 817 | 0.135529 | 4.95E+08 | 0.365547 |
Down | CFTR | 800 | 0.168404 | 4.5E+08 | 0.378823 |
Down | TK1 | 188 | 0.034997 | 43,663,230 | 0.331089 |
Down | ECT2 | 164 | 0.020509 | 39,431,940 | 0.325989 |
Down | FKBP5 | 157 | 0.028064 | 15,963,868 | 0.346288 |
Down | ANLN | 153 | 0.021564 | 38,168,832 | 0.325066 |
Down | ATP2A2 | 148 | 0.027131 | 19,656,040 | 0.363859 |
Down | BCL6 | 142 | 0.022279 | 29,419,916 | 0.314181 |
Down | TOP2A | 132 | 0.018571 | 16,838,266 | 0.361426 |
Down | ZBTB16 | 132 | 0.025165 | 14,500,206 | 0.349976 |
Down | S100A9 | 124 | 0.01355 | 11,186,464 | 0.352219 |
Down | CEP55 | 123 | 0.019583 | 21,505,878 | 0.316891 |
Down | BLM | 108 | 0.014259 | 18,458,556 | 0.321945 |
Down | AGTR1 | 100 | 0.019518 | 14,083,216 | 0.313564 |
Down | SAMHD1 | 94 | 0.011463 | 12,340,270 | 0.337357 |
Down | S100A8 | 88 | 0.011637 | 8,662,548 | 0.361486 |
Down | GRAP2 | 86 | 0.011721 | 16,819,438 | 0.305936 |
Down | CBS | 83 | 0.011248 | 20,466,334 | 0.301591 |
Down | SOCS3 | 83 | 0.011071 | 9,067,820 | 0.324888 |
Down | GFI1B | 80 | 0.011791 | 21,469,034 | 0.299012 |
Down | APOB | 78 | 0.014102 | 9,290,092 | 0.319133 |
Down | PCK1 | 77 | 0.004102 | 12,732,476 | 0.305408 |
Down | MARK3 | 76 | 0.008497 | 19,265,788 | 0.304512 |
Down | HMOX2 | 75 | 0.011098 | 15,258,770 | 0.312053 |
Down | PCNT | 74 | 0.011297 | 9,190,430 | 0.312261 |
Down | PIK3C2A | 69 | 0.005568 | 8,768,122 | 0.313053 |
Down | KIF14 | 69 | 0.01035 | 12,506,564 | 0.304668 |
Down | WASF1 | 67 | 0.009478 | 18,219,554 | 0.29633 |
Down | ARNTL | 65 | 0.00974 | 19,494,854 | 0.295526 |
Down | ALOX5 | 65 | 0.010921 | 7,343,824 | 0.306424 |
Down | MCM10 | 64 | 0.006773 | 8,807,396 | 0.306438 |
Down | THBS1 | 64 | 0.008915 | 6,203,038 | 0.312694 |
Down | VSIG4 | 64 | 0.010353 | 10,534,518 | 0.302037 |
Down | WWC1 | 64 | 0.007241 | 14,604,594 | 0.301647 |
Down | MELK | 63 | 0.008554 | 18,629,232 | 0.283953 |
Down | P2RY12 | 63 | 0.008962 | 9,063,088 | 0.286641 |
Down | PPL | 62 | 0.007851 | 16,137,388 | 0.297313 |
Down | MYBL2 | 59 | 0.006189 | 16,766,208 | 0.291964 |
Down | FAM107A | 59 | 0.006172 | 12,510,302 | 0.289688 |
Down | GRIP1 | 58 | 0.008069 | 3,384,760 | 0.320055 |
Down | ELF3 | 56 | 0.004945 | 7,205,142 | 0.309118 |
Down | PALLD | 55 | 0.00509 | 15,467,012 | 0.293274 |
Down | CTH | 54 | 0.007754 | 5,179,060 | 0.296908 |
Down | EIF4EBP1 | 53 | 0.005367 | 9,748,852 | 0.303946 |
Down | KNG1 | 53 | 0.007017 | 4,204,766 | 0.304243 |
Down | GLUL | 51 | 0.00728 | 10,616,752 | 0.30116 |
Down | SLC2A1 | 51 | 0.004557 | 8,307,646 | 0.303974 |
Down | HP | 51 | 0.006741 | 3,398,298 | 0.314741 |
Down | RPGR | 50 | 0.004441 | 10,097,488 | 0.29384 |
Down | TLR2 | 50 | 0.00754 | 8,322,330 | 0.294595 |
Down | GRB7 | 49 | 0.004147 | 4,832,846 | 0.308113 |
Down | PPEF1 | 49 | 0.001983 | 3,327,232 | 0.298276 |
Down | TXNRD1 | 49 | 0.00627 | 2,860,122 | 0.328561 |
Down | NAMPT | 48 | 0.005035 | 10,420,710 | 0.290538 |
Down | BMP7 | 47 | 0.007622 | 4,442,306 | 0.286981 |
Down | CA14 | 47 | 0.005218 | 4,884,858 | 0.279189 |
Down | CCR1 | 46 | 0.008305 | 11,217,842 | 0.27812 |
Down | CDC45 | 45 | 0.004479 | 3,231,162 | 0.30618 |
Down | ARG1 | 45 | 0.004931 | 2,347,856 | 0.32381 |
Down | SPC24 | 43 | 0.005356 | 6,589,710 | 0.294834 |
Down | FGR | 43 | 0.003434 | 3,020,950 | 0.303452 |
Down | KIF5C | 42 | 0.004876 | 2,365,086 | 0.319586 |
Down | IL1R2 | 42 | 0.006825 | 9,489,620 | 0.289265 |
Down | SERPINA3 | 42 | 0.005518 | 4,047,110 | 0.293168 |
Down | DEPDC1B | 42 | 0.002978 | 9,632,346 | 0.260838 |
Down | SLC4A7 | 41 | 0.006314 | 2,752,106 | 0.316232 |
Down | SERPINA5 | 41 | 0.003604 | 13,750,404 | 0.273206 |
Down | MPP3 | 40 | 0.008262 | 9,328,402 | 0.297003 |
Down | NCEH1 | 40 | 0.009405 | 3,554,728 | 0.304214 |
Down | SLC1A1 | 38 | 0.008678 | 2,278,154 | 0.320573 |
Down | CLSPN | 38 | 0.003668 | 3,801,300 | 0.294343 |
Down | BCAT1 | 38 | 0.0052 | 9,066,238 | 0.269657 |
Down | MYH6 | 38 | 0.005049 | 1,731,786 | 0.308578 |
Down | IL20RA | 37 | 0.005252 | 8,769,348 | 0.267901 |
Down | HOOK1 | 37 | 0.005558 | 7,195,380 | 0.279177 |
Down | FLT3 | 37 | 0.002948 | 1,938,440 | 0.292408 |
Down | ADAMTS4 | 37 | 0.005524 | 2,338,476 | 0.307519 |
Down | CAMSAP3 | 36 | 0.003339 | 4,795,892 | 0.29578 |
Down | PLA2G2A | 35 | 0.003637 | 1,686,594 | 0.300565 |
Down | FOSL1 | 34 | 0.004151 | 10,955,318 | 0.269402 |
Down | NQO1 | 34 | 0.001945 | 5,351,260 | 0.289201 |
Down | ELANE | 34 | 0.005024 | 2,289,646 | 0.302834 |
Down | KCND3 | 34 | 0.002555 | 9,153,178 | 0.28203 |
Down | EPN3 | 34 | 0.005073 | 7,423,282 | 0.280302 |
Down | GPR183 | 34 | 0.003642 | 4,243,792 | 0.256783 |
Down | CD109 | 34 | 0.006381 | 3,655,940 | 0.303565 |
Down | TUBA3E | 34 | 0.003459 | 6,711,886 | 0.289048 |
Down | TGFBR3 | 33 | 0.005143 | 1,983,082 | 0.267386 |
Down | NID1 | 33 | 0.004536 | 1,702,236 | 0.311503 |
Down | STEAP3 | 33 | 0.004665 | 2,788,716 | 0.285365 |
Down | AMD1 | 32 | 0.005714 | 3,154,782 | 0.29099 |
Down | EDNRB | 31 | 0.003092 | 7,273,156 | 0.265368 |
Down | IL17RB | 31 | 0.004227 | 6,381,040 | 0.261527 |
Down | SLC19A2 | 30 | 0.004653 | 2,505,974 | 0.281302 |
Down | SLC22A16 | 30 | 0.004545 | 3,831,872 | 0.240618 |
Down | PHACTR3 | 29 | 0.002193 | 6,417,862 | 0.280976 |
Down | LAPTM5 | 29 | 0.003298 | 2,735,158 | 0.274317 |
Down | ANGPTL4 | 29 | 0.003467 | 1,447,446 | 0.325163 |
Down | PPM1E | 29 | 0.002894 | 5,733,032 | 0.270427 |
Down | E2F2 | 28 | 0.002816 | 5,508,320 | 0.28041 |
Down | SERPINE1 | 28 | 0.001474 | 2,497,574 | 0.271302 |
Down | ACPP | 28 | 0.003084 | 2,749,550 | 0.291223 |
Down | KRT7 | 28 | 0.002861 | 1,288,592 | 0.315774 |
Down | SERPINB8 | 28 | 0.002944 | 3,167,812 | 0.28186 |
Down | FREM2 | 28 | 0.003954 | 3,395,758 | 0.276661 |
Down | RNF157 | 28 | 0.002172 | 6,196,626 | 0.265551 |
Down | PPIP5K2 | 28 | 0.003886 | 8,572,108 | 0.270014 |
Down | F8 | 27 | 0.002839 | 4,879,016 | 0.274836 |
Down | TUBAL3 | 27 | 0.002055 | 1,052,840 | 0.318915 |
Down | ELL2 | 26 | 0.003971 | 6,281,508 | 0.255859 |
Down | GRB14 | 25 | 0.002326 | 3,092,024 | 0.28378 |
Down | IRAK3 | 25 | 0.00257 | 6,900,170 | 0.265897 |
Down | MANEA | 25 | 0.004508 | 5,075,608 | 0.263869 |
Down | CLEC7A | 25 | 0.004246 | 4,293,212 | 0.277095 |
Down | KLF10 | 24 | 0.001607 | 3,013,994 | 0.281339 |
Down | GNMT | 24 | 0.00165 | 3,015,768 | 0.269136 |
Down | ART3 | 24 | 0.002904 | 2,401,360 | 0.255748 |
Down | LRRC8E | 24 | 0.003739 | 4,188,308 | 0.288665 |
Down | SLA | 23 | 0.001714 | 1,003,510 | 0.289329 |
Down | CLEC4G | 23 | 0.002667 | 2,376,260 | 0.277495 |
Down | TUBB4A | 5 | 1.28E−04 | 181,440 | 0.250652 |
Down | CD38 | 4 | 0 | 0 | 0.268176 |
Down | FCGR3A | 4 | 1.01E−04 | 73,756 | 0.268385 |
Down | F5 | 3 | 8.10E−07 | 708 | 0.248641 |
Down | EHF | 2 | 7.11E−06 | 4180 | 0.254842 |
Down | KIAA1549 | 2 | 4.16E−04 | 193,604 | 0.261391 |
Down | S100A3 | 2 | 1.84E−05 | 45,822 | 0.254376 |
Down | ADH1B | 2 | 3.40E−05 | 28,184 | 0.233546 |
Down | PAPSS2 | 2 | 1.05E−05 | 8726 | 0.251868 |
Down | PTX3 | 1 | 0 | 0 | 0.19143 |
Down | IL15RA | 1 | 0 | 0 | 0.234199 |
Down | EDN1 | 1 | 0 | 0 | 0.209723 |
Down | SERPINF2 | 1 | 0 | 0 | 0.232451 |
Down | ZNF366 | 1 | 0 | 0 | 0.282018 |
Down | ACR | 1 | 0 | 0 | 0.214588 |
Down | MATN3 | 1 | 0 | 0 | 0.222881 |
Down | CNR1 | 1 | 0 | 0 | 0.216205 |
Down | LBP | 1 | 0 | 0 | 0.240053 |
Down | ALOX5AP | 1 | 0 | 0 | 0.23456 |
Down | SCGN | 1 | 0 | 0 | 0.23353 |
Down | MAMDC2 | 1 | 0 | 0 | 0.248745 |
Down | CDKL5 | 1 | 0 | 0 | 0.219891 |
Down | CENPM | 1 | 0 | 0 | 0.231833 |
Down | KCNIP2 | 1 | 0 | 0 | 0.219995 |
Down | CPM | 1 | 0 | 0 | 0.24533 |
Down | GPSM2 | 1 | 0 | 0 | 0.245855 |
Down | LSAMP | 1 | 0 | 0 | 0.215756 |
Down | KCNK3 | 1 | 0 | 0 | 0.219353 |
Down | ALOX15B | 1 | 0 | 0 | 0.234981 |
Down | ST6GALNAC3 | 1 | 0 | 0 | 0.233263 |
Down | GPRC5A | 1 | 0 | 0 | 0.274755 |
Down | SLC31A2 | 1 | 0 | 0 | 0.215287 |
Down | MARVELD2 | 1 | 0 | 0 | 0.218671 |
Down | SNTG2 | 1 | 0 | 0 | 0.229 |
Down | TRHDE | 1 | 0 | 0 | 0.208786 |
Down | SIGLEC7 | 1 | 0 | 0 | 0.245229 |
Down | SMTNL2 | 1 | 0 | 0 | 0.265519 |
Down | ANXA3 | 1 | 0 | 0 | 0.274755 |
Down | F13A1 | 1 | 0 | 0 | 0.248745 |
Down | ANKRD7 | 1 | 0 | 0 | 0.233438 |
Down | KCNS2 | 1 | 0 | 0 | 0.219721 |
Down | SIGLEC9 | 1 | 0 | 0 | 0.227565 |
Down | SIGLEC10 | 1 | 0 | 0 | 0.282018 |
Down | C20orf197 | 1 | 0 | 0 | 0.282018 |
Down | SCGB1D2 | 1 | 0 | 0 | 0.226548 |
Down | IL1RL1 | 1 | 0 | 0 | 0.21698 |
Down | PLIN2 | 1 | 0 | 0 | 0.241935 |
Down | CD163 | 1 | 0 | 0 | 0.239403 |
Down | HPR | 1 | 0 | 0 | 0.240053 |
Target gene—miRNA regulatory network construction
Regulation | Target Genes | Degree | MicroRNA | Regulation | Target Genes | Degree | TF |
---|---|---|---|---|---|---|---|
Up | FSCN1 | 99 | hsa-mir-4533 | Up | FSCN1 | 62 | ESRRA |
Up | ESR1 | 72 | hsa-mir-548ac | Up | APOA1 | 48 | RERE |
Up | TMEM30B | 64 | hsa-mir-548i | Up | COL1A1 | 21 | HMG20B |
Up | SCN2B | 46 | hsa-mir-5585-3p | Up | HBB | 16 | THRAP3 |
Up | CENPA | 35 | hsa-mir-6750-3p | Up | LCK | 15 | ATF1 |
Up | APOA1 | 22 | hsa-mir-6722-5p | Up | FOXS1 | 14 | YBX1 |
Up | PPP2R2B | 14 | hsa-mir-149-3p | Up | CENPA | 10 | SAP30 |
Up | TP63 | 12 | hsa-mir-1178-3p | Up | SCN2B | 5 | RCOR2 |
Up | PYHIN1 | 5 | hsa-mir-205-3p | Up | TMEM30B | 5 | ZNF24 |
Up | APLNR | 2 | hsa-mir-10b-5p | Up | APLNR | 4 | FOXJ2 |
Up | PTN | 1 | hsa-mir-155-5p | Up | NRG1 | 2 | SUZ12 |
Up | LCK | 1 | hsa-mir-335-5p | Up | PTN | 2 | L3MBTL2 |
Up | CD247 | 1 | hsa-mir-346 | Up | UCHL1 | 2 | MAZ |
Down | FKBP5 | 88 | hsa-mir-200c-3p | Up | ESR1 | 1 | EZH2 |
Down | PCLAF | 62 | hsa-mir-1273g-3p | Up | ZAP70 | 1 | ZFX |
Down | CEP55 | 57 | hsa-mir-1244 | Down | SOCS3 | 48 | MXD3 |
Down | ATP2A2 | 55 | hsa-mir-4789-3p | Down | BCL6 | 44 | ARID4B |
Down | TK1 | 45 | hsa-mir-766-3p | Down | FKBP5 | 43 | CBFB |
Down | ZBTB16 | 43 | hsa-mir-1976 | Down | ANLN | 38 | TAF7 |
Down | SAMHD1 | 26 | hsa-mir-3124-3p | Down | ATP2A2 | 35 | CREM |
Down | TOP2A | 17 | hsa-mir-186-5p | Down | CBS | 31 | IKZF1 |
Down | BCL6 | 13 | hsa-mir-339-5p | Down | BLM | 19 | ZNF501 |
Down | ECT2 | 13 | hsa-mir-132-3p | Down | ECT2 | 15 | KLF16 |
Down | CFTR | 9 | hsa-mir-145-5p | Down | CEP55 | 10 | FOSL2 |
Down | S100A9 | 7 | hsa-mir-4679 | Down | GRAP2 | 10 | CEBPD |
Down | AGTR1 | 5 | hsa-mir-410-3p | Down | ZBTB16 | 4 | TRIM28 |
Down | ANLN | 5 | hsa-mir-503-5p | Down | S100A8 | 3 | STAT3 |
Down | BLM | 3 | hsa-mir-193b-3p | Down | S100A9 | 2 | CEBPG |
Down | AGTR1 | 1 | EZH2 |
Target gene—TF regulatory network construction
Receiver operating characteristic (ROC) curve analysis
RT-PCR analysis
Identification of candidate small molecules
Sl. No/ Code | Over expressed gene: ESR1 | Over expressed gene: LCK | Over expressed gene: PPP2R2B | Over expressed gene: PYHIN 1 | Over expressed gene: TP63 | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
PDB: 4PXM | PDB:1KSW | PDB: 2HV7 | PDB: 3VD8 | PDB: 6RU6 | |||||||||||
Total Score | Crash (-Ve) | Polar | Total Score | Crash (-Ve) | Polar | Total Score | Crash (−Ve) | Polar | Total Score | Crash (−Ve) | Polar | Total Score | Crash (−Ve) | Polar | |
HIM1 | 5.097 | − 4.375 | 0.114 | 4.258 | − 1.555 | 1.784 | 4.904 | − 0.870 | 0.004 | 5.794 | − 0.514 | 3.828 | 5.770 | − 1.440 | 2.231 |
HIM2 | 4.057 | − 6.172 | 0.039 | 4.624 | − 0.997 | 1.959 | 4.906 | − 0.468 | 1.517 | 5.052 | − 0.780 | 3.415 | 5.414 | − 1.529 | 2.444 |
HIM3 | 5.353 | − 5.309 | 0.161 | 4.578 | − 1.492 | 1.790 | 5.042 | − 1.845 | 1.073 | 5.680 | − 0.804 | 3.956 | 5.350 | − 1.170 | 2.316 |
HIM4 | 3.976 | − 5.132 | 0.167 | 3.839 | − 1.635 | 1.196 | 6.328 | − 1.172 | 1.128 | 4.966 | − 0.666 | 1.818 | 5.627 | − 1.416 | 2.320 |
HIM5 | 2.707 | − 7.759 | 0.179 | 4.067 | − 0.997 | 1.987 | 5.254 | − 0.674 | 1.618 | 4.563 | − 1.068 | 2.935 | 5.698 | − 1.240 | 2.485 |
HIM6 | 5.948 | − 3.902 | 1.796 | 5.229 | − 0.707 | 3.656 | 6.766 | − 1.424 | 1.858 | 6.670 | − 0.941 | 5.519 | 6.218 | − 1.468 | 2.578 |
HIM7 | 5.019 | − 7.055 | 0.203 | 4.382 | − 2.443 | 3.329 | 6.028 | − 0.629 | 1.660 | 5.374 | − 1.876 | 0.670 | 6.627 | − 1.484 | 2.579 |
HIM8 | 4.429 | − 3.983 | 0.344 | 4.150 | − 4.382 | 4.210 | 6.794 | − 1.279 | 1.129 | 5.468 | − 0.769 | 3.444 | 5.842 | − 2.088 | 2.272 |
HIM9 | 3.722 | − 5.956 | 0.197 | 4.051 | − 2.006 | 0.002 | 6.116 | − 0.597 | 1.717 | 5.407 | − 0.565 | 1.370 | 5.877 | − 2.054 | 0.792 |
HIM10 | 6.771 | − 3.977 | 1.836 | 5.176 | − 3.512 | 4.023 | 5.332 | − 1.378 | 3.349 | 6.071 | − 0.923 | 3.854 | 5.825 | − 0.966 | 3.672 |
HIM11 | 3.775 | − 6.079 | 0.898 | 6.998 | − 2.086 | 3.842 | 8.678 | − 1.065 | 2.876 | 5.087 | − 0.881 | 1.854 | 5.948 | − 1.015 | 1.202 |
HIM12 | 0.190 | − 8.149 | 0.022 | 5.302 | − 2.305 | 3.475 | 5.227 | − 1.636 | 0.710 | 7.322 | − 1.128 | 4.099 | 6.237 | − 2.562 | 2.171 |
HIM13 | 4.523 | − 4.537 | 0.014 | 4.840 | − 0.664 | 3.305 | 6.181 | − 2.966 | 3.523 | 5.281 | − 0.503 | 3.981 | 5.905 | − 1.136 | 2.218 |
HIM14 | 5.247 | − 3.183 | 0.000 | 4.888 | − 1.296 | 2.563 | 5.037 | − 0.377 | 1.647 | 7.057 | − 0.799 | 4.256 | 6.116 | − 1.366 | 2.438 |
HIM15 | 4.633 | − 4.173 | 0.180 | 3.756 | − 0.710 | 2.072 | 5.188 | − 1.559 | 1.143 | 5.570 | − 1.125 | 3.718 | 6.238 | − 1.708 | 2.443 |
HIM16 | 4.588 | − 2.883 | 0.000 | 6.027 | − 1.099 | 3.903 | 5.606 | − 0.987 | 4.197 | 5.661 | − 0.926 | 2.751 | 7.263 | − 1.533 | 4.212 |
HIM17 | 3.944 | − 4.806 | 0.236 | 5.329 | − 0.590 | 2.798 | 4.830 | − 1.682 | 1.617 | 6.234 | − 0.830 | 3.912 | 5.366 | − 1.257 | 3.022 |
HTZ1 | 0.593 | − 7.518 | 0 | 4.221 | − 0.692 | 1.975 | 3.993 | − 0.539 | 0.003 | 5.284 | − 0.566 | 1.432 | 5.227 | − 1.045 | 0.903 |
HTZ2 | − 1.770 | − 8.477 | 0.000 | 4.055 | − 1.438 | 2.877 | 4.388 | − 1.665 | 1.170 | 4.100 | − 0.546 | 3.017 | 4.563 | − 0.976 | 1.266 |
HTZ3 | 4.649 | − 5.870 | 0.148 | 5.104 | − 0.861 | 3.922 | 4.243 | − 1.539 | 1.933 | 5.304 | − 1.370 | 1.398 | 5.138 | − 1.217 | 1.930 |
HTZ4 | − 3.169 | − 12.002 | 0.482 | 4.173 | − 1.898 | 1.864 | 4.654 | − 1.627 | 1.128 | 5.163 | − 0.745 | 1.304 | 5.084 | − 1.143 | 1.018 |
HTZ5 | 4.021 | − 12.325 | 0.246 | 3.215 | − 1.481 | 4.232 | 3.256 | − 6.374 | 2.317 | 2.382 | − 5.263 | 1.238 | 4.623 | − 0.951 | 1.280 |
HTZ6 | 6.605 | − 3.866 | 1.6487 | 4.004 | − 1.104 | 2.851 | 5.834 | − 1.310 | 3.111 | 5.286 | − 1.530 | 1.436 | 6.336 | − 2.326 | 3.781 |
HTZ7 | 4.977 | − 5.434 | 0.655 | 5.197 | − 2.040 | 3.250 | 5.352 | − 1.371 | 1.172 | 6.138 | − 1.734 | 1.627 | 4.908 | − 1.057 | 1.335 |
HTZ8 | 1.025 | − 8.223 | 0.000 | 3.549 | − 1.310 | 2.403 | 4.024 | − 3.825 | 2.440 | 4.980 | − 0.593 | 1.474 | 5.164 | − 1.291 | 0.999 |
HTZ9 | 3.386 | − 7.041 | 0.194 | 5.567 | − 1.622 | 3.057 | 6.792 | − 2.581 | 1.088 | 5.794 | − 0.683 | 1.774 | 6.053 | − 1.408 | 1.037 |
HTZ10 | 4.744 | − 5.463 | 0.837 | 4.520 | − 2.469 | 3 | 7.758 | − 1.518 | 3.765 | 5.345 | − 1.133 | 3.661 | 7.507 | − 2.080 | 4.086 |
HTZ11 | 2.991 | − 6.177 | 0 | 3.453 | − 0.721 | 1.266 | 4.841 | − 1.738 | 0.045 | 4.368 | − 0.805 | 1.074 | 6.176 | − 1.380 | 1.511 |
HTZ12 | 4.810 | − 6.157 | 0.275 | 5.296 | − 2.814 | 3.605 | 5.138 | − 1.840 | 2.189 | 5.083 | − 0.870 | 1.536 | 5.592 | − 1.321 | 1.525 |
HTZ13 | 4.868 | − 3.837 | 0 | 4.863 | − 0.535 | 2.405 | 4.656 | − 0.681 | 3.152 | 4.246 | − 2.335 | 0.529 | 6.404 | − 0.975 | 2.954 |
HTZ14 | 5.646 | − 3.473 | 0 | 4.948 | − 0.801 | 2.324 | 4.953 | − 1.672 | 1.066 | 5.058 | − 1.174 | 1.121 | 5.114 | − 1.299 | 1.296 |
HTZ15 | 3.428 | − 4.957 | 0.348 | 3.949 | − 0.614 | 1.873 | 4.049 | − 0.787 | 1.224 | 4.796 | − 1.066 | 1.489 | 3.510 | − 0.607 | 0.461 |
HTZ16 | 4.227 | − 4.787 | 0.298 | 4.654 | − 1.534 | 2.096 | 6.143 | − 1.204 | 2.879 | 4.854 | − 0.994 | 1.564 | 7.102 | − 0.917 | 3.001 |
HTZ17 | 3.784 | − 5.018 | 0.380 | 3.661 | − 0.897 | 1.676 | 4.016 | − 1.179 | 1.384 | 4.039 | − 0.569 | 2.706 | 4.256 | − 1.040 | 1.236 |
HTZ STD | 4.722 | − 1.084 | 1.063 | 3.319 | − 0.890 | 3.033 | 3.564 | − 0.272 | 2.367 | 3.394 | − 0.882 | 1.169 | 4.237 | − 0.801 | 1.855 |