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01.12.2017 | Research | Ausgabe 1/2017 Open Access

Journal of Ovarian Research 1/2017

Identification of factors that impact recurrence in patients with borderline ovarian tumors

Zeitschrift:
Journal of Ovarian Research > Ausgabe 1/2017
Autoren:
Xi Chen, Chenyan Fang, Tao Zhu, Ping Zhang, Aijun Yu, Shihua Wang
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​s13048-017-0316-5) contains supplementary material, which is available to authorized users.

Abstract

Background

The lack of consensus around best practices for management of borderline ovarian tumors (BOT) is, in part, to the lack of available data and of clarity in interpreting relationships among various factors that impact outcomes. The objective of this study was to identify clinicopathological factors that impact prognosis of patients with borderline ovarian tumors (BOT) and to address features of this disease with the objective of providing clarity in decision making around management of BOT.

Results

A total of 178 BOT patients were included in this study, with a median age of 43 years and a median follow-up time of 37 months. Thirty-two (18.0%) recurrences and 5 (2.8%) deaths were observed in this study group. Multivariate analysis showed that fertility-preserving surgery (P = 0.0223 for bilateral cystectomy) and invasive implants (P = 0.0030) were significantly associated with worse PFS, whereas lymphadenectomy (P = 0.0129) was related to improved PFS. No factors were found to be associated with OS due to the limited number of deaths. In addition, patients with serous BOT more commonly had abnormal levels of CA125, while patients with mucinous BOT more commonly had abnormal levels of CEA. Patients with abnormal levels of CA125, or CA19-9, or HE4 had significantly larger tumor sizes.

Conclusions

Our study reveals the impact of certain types of fertility-preserving surgery, lymphadenectomy and invasive implants on PFS of BOT patients. Blood cancer markers may be associated with histology and size of BOT. Our findings may assist in selection of optimum treatment for BOT patients.
Zusatzmaterial
Additional file 1: Table S1. Clinicopathological features of patients with lymphadenectomy. Table S2. Clinicopathological features of patients with lymph node metastasis. Table S3. Clinicopathological features of patients with chemotherapy. Table S4. Information of recurrence sites. Table S5. Recurrence outcomes in patients based on clinicopathological classifications. (DOC 92 kb)
13048_2017_316_MOESM1_ESM.doc
Literatur
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