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22.02.2021 | Sleep Breathing Physiology and Disorders • Original Article

Identification of hub genes correlated with sleep deprivation using co-expression analysis

verfasst von: Hao-jie Xu, Shi-zhu Lin, Kai Shi, Jin-jia Qiu, Jia-Min Hu, Zeng-gui Yu, Dong-sheng Dai, Na Zhang, Min Liang, Hong-da Cai, Kai Zeng, Xiao-dan Wu

Erschienen in: Sleep and Breathing | Ausgabe 4/2021

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Abstract

Background

Sleep deprivation (SD) has become a serious concern worldwide. This study aimed to identify key modules and candidate hub genes correlated with diseases caused by SD, using co-expression analysis.

Methods

The weighted gene co-expression network analysis was performed to construct a co-expression network of hub genes correlated with SD. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses were performed to search for signaling pathways. The protein–protein interaction network analysis of central genes was performed to recognize the interactions among central genes. Molecular Complex Detection, a plugin in Cytoscape, was used to discover the hub gene clusters involved in SD.

Results

A total of 564 genes in the yellow module were identified based on the results of topological overlap measure–based clustering. The yellow module showed a pivotal correlation with SD. Six hub gene clusters prominently associated with SD were identified. Heat shock protein family and circadian clock genes among them may be the hub genes involved in SD.

Conclusions

These genes and pathways might become therapeutic targets with clinical usefulness in the future.

Graphical abstract

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Titel: Identification of hub genes correlated with sleep deprivation using co-expression analysis
verfasst von: Hao-jie Xu
Shi-zhu Lin
Kai Shi
Jin-jia Qiu
Jia-Min Hu
Zeng-gui Yu
Dong-sheng Dai
Na Zhang
Min Liang
Hong-da Cai
Kai Zeng
Xiao-dan Wu
Publikationsdatum: 22.02.2021
Verlag: Springer International Publishing
Erschienen in: Sleep and Breathing / Ausgabe 4/2021
Print ISSN: 1520-9512
Elektronische ISSN: 1522-1709
DOI: https://doi.org/10.1007/s11325-021-02321-3

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Identification of hub genes correlated with sleep deprivation using co-expression analysis

Abstract

Background

Methods

Results

Conclusions

Graphical abstract

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Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

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Abstract

Background

Methods

Results

Conclusions

Graphical abstract

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