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Endocrine

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30.09.2023 | Original Article

Identification of influence factors in overweight population through an interpretable risk model based on machine learning: a large retrospective cohort

verfasst von: Wei Lin, Songchang Shi, Huiyu Lan, Nengying Wang, Huibin Huang, Junping Wen, Gang Chen

Erschienen in: Endocrine | Ausgabe 3/2024

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Abstract

Background

The identification of associated overweight risk factors is crucial to future health risk predictions and behavioral interventions. Several consensus problems remain in machine learning, such as cross-validation, and the resulting model may suffer from overfitting or poor interpretability.

Methods

This study employed nine commonly used machine learning methods to construct overweight risk models. The general community are the target of this study, and a total of 10,905 Chinese subjects from Ningde City in Fujian province, southeast China, participated. The best model was selected through appropriate verification and validation and was suitably explained.

Results

The overweight risk models employing machine learning exhibited good performance. It was concluded that CatBoost, which is used in the construction of clinical risk models, may surpass previous machine learning methods. The visual display of the Shapley additive explanation value for the machine model variables accurately represented the influence of each variable in the model.

Conclusions

The construction of an overweight risk model using machine learning may currently be the best approach. Moreover, CatBoost may be the best machine learning method. Furthermore, combining Shapley’s additive explanation and machine learning methods can be effective in identifying disease risk factors for prevention and control.

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Titel: Identification of influence factors in overweight population through an interpretable risk model based on machine learning: a large retrospective cohort
verfasst von: Wei Lin
Songchang Shi
Huiyu Lan
Nengying Wang
Huibin Huang
Junping Wen
Gang Chen
Publikationsdatum: 30.09.2023
Verlag: Springer US
Erschienen in: Endocrine / Ausgabe 3/2024
Print ISSN: 1355-008X
Elektronische ISSN: 1559-0100
DOI: https://doi.org/10.1007/s12020-023-03536-y

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Identification of influence factors in overweight population through an interpretable risk model based on machine learning: a large retrospective cohort