Background
Methods
Participants
Knee OA assessments
Data analysis
Results
All participants (N = 250) | 1 (No disability) (N = 79) | 2 (mild disability) (N = 67) | 3 (moderate disability) (N = 76) | 4 (severe disability) (N = 28) | P - values | |
---|---|---|---|---|---|---|
Age (years) | 65.44 (8.70) | 66.7 (7.97) | 66.49 (9.85) | 64.55 (8.35) | 62.8 (6.76) | 0.112 |
BMI (kg/m2) | 26.07 (4.36) | 25.13 (3.61) | 25.30 (4.48) | 27.37 (4.95) | 27.07 (3.53) | 0.003a |
Duration of knee pain (years) | 5.02 (3.78) | 5.56 (4.24) | 5.27 (3.72) | 4.24 (3.14) | 4.54 (3.18) | 0.129 |
Gender (female/male) | 216/34 | 67/12 | 57/10 | 68/8 | 24/4 | .858 |
Cluster variables and phenotypes of knee OA
Cluster | ||||
---|---|---|---|---|
1 (No disability) (N = 79) | 2 (mild disability) (N = 67) | 3 (moderate disability) (N = 76) | 4 (severe disability) (N = 28) | |
the difficulty level of maintaining a standing position: median (Q1, Q3) | 0 (0,0) | 1(1,1) | 2 (2,2) | 3 (3,3) |
stair climbing time (seconds): mean | 12.43 | 15.29 | 18.01 | 18.23 |
walking time (seconds): mean | 53.72 | 58.51 | 63.37 | 71.02 |
Cluster 1 (3) (N = 79) | Cluster 2 (4) (N = 67) | Cluster 3 (2) (N = 76) | Cluster 4 (1) (N = 28) | p-valuea | |
---|---|---|---|---|---|
Pain scale: Mean ± SD | 3.88 ± 2.68 | 4.06 ± 2.44 | 4.82 ± 2.61 | 5.18 ± 3.20 | 0.012* |
FPROM (degree): Mean ± SD | 131.22 ± 9.92 | 127.69 ± 12.62 | 123.42 ± 16.93 | 118.96 ± 24.58 | 0.001* |
EPROM (degree): Mean ± SD | 3.19 ± 4.92 | 5.48 ± 5.73 | 5.25 ± 5.95 | 5.64 ± 6.18 | 0.032* |
Knee flexor muscle power: Median (Q1, Q3) | 4 (4,5) | 4 (4,5) | 4 (3.25,5) | 4 (4,5) | 0.003 |
Knee extensor muscle power: Median (Q1, Q3) | 5 (4,5) | 5 (4,5) | 4 (4,5) | 5 (4,5) | < 0.001 |
Acquisition of good and service: Median (Q1, Q3) | 1 (0,2) | 2 (1,2) | 2 (2,3.75) | 3 (2,4) | < 0.001 |
Community life: Median (Q1, Q3) | 1 (0,2) | 2 (1,2) | 2 (2,3) | 3 (1,4) | < 0.001 |
Variables | Impairment and participation variables included in the model | R | Adjusted R2 | F (p -value) |
---|---|---|---|---|
Maintaining a standing position | ||||
All subject (N = 250) | Extensor, EPROM, Acquisition of good and service, Pain scale, FPROM, Flexor, Community life | .365 | .108 | 5.317 (<.001) |
Cluster 1 (N = 79) | Extensor, Pain scale, Acquisition of good and service, FPROM, EPROM, Flexor, Community life | .602 | .139 | 1.624 (.186) |
Timed walking | ||||
All subject (N= 250) | Extensor, EPROM, Acquisition of good and service, Pain scale, FPROM, Flexor, Community life | .540 | .272 | 14.258 (<.001) |
Cluster 1 (N = 79) | Extensor, Pain scale, Acquisition of good and service, FPROM, EPROM, Flexor, Community life | .713 | .337 | 2.957 (.027) |
Cluster 2 (N = 67) | Extensor, EPROM, Acquisition of good and service, Pain scale, FPROM, Community life, Flexor | .619 | .319 | 6.021 (<.001) |
Cluster 3 (N = 76) | Extensor, Acquisition of good and service, Pain scale, Flexor, FPROM, EPROM, Community life | .470 | .144 | 2.874 (.011) |
Cluster 4 (N = 28) | Extensor, FPROM, Pain scale, EPROM, Community life, Flexor, Acquisition of good and service | .550 | .220 | 3.665 (.002) |
Timed stair test | ||||
All subject (N = 250) | Extensor, EROM, Acquisition of good and service, Pain scale, FPROM, Flexor, Community life | .563 | .297 | 16.057 (<.001) |
Cluster 1 (N = 79) | Extensor, Pain scale, Acquisition of good and service, FPROM, EPROM, Flexor, Community life | .744 | .397 | 3.540 (.012) |
Cluster 2 (N = 67) | Extensor, EPROM, Acquisition of good and service, Pain scale, FPROM, Community life, Flexor | .597 | .290 | 5.366 (<.001) |
Cluster 3 (N = 76) | Extensor, Acquisition of good and service, Pain scale, Flexor, FPROM, EPROM, Community life | .433 | .108 | 2.345 (.033) |
Cluster 4 (N = 28) | Extensor, FPROM, Pain scale, EPROM, Community life, Flexor, Acquisition of good and service | .495 | .155 | 2.730 (.016) |