Identification of pattern recognition receptors participating in the innate immune response to Tembusu virus
- 01.06.2025
- Brief Report
Erschienen in:
- Verfasst von
- Jingjing Huang
- Xiaoyang Hu
- Duo Peng
- Qiong Li
- Yinuo Song
- Dabing Zhang
- Erschienen in
- Archives of Virology | Ausgabe 6/2025
Abstract
The pattern recognition receptors (PRRs) participating in the innate immune response to Tembusu virus (TMUV) were investigated using duck embryo fibroblasts (DEFs). TMUV infection induced significant upregulation of RIG-I and MDA5 and strong IFN-α, IFN-β, IL-6, and Mx responses. Overexpression of RIG-I or MDA5 resulted in increased IFN-α, IFN-β, IL-6, and Mx expression and decreased TMUV replication. Conversely, knockdown of RIG-I or MDA5 resulted in decreased IFN-α, IFN-β, IL-6, and Mx expression and increased TMUV replication. These findings demonstrate that RIG-I and MDA5 are essential sensors in the innate immune defense against TMUV, orchestrating cytokine production and restricting viral replication.
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- Titel
- Identification of pattern recognition receptors participating in the innate immune response to Tembusu virus
- Verfasst von
-
Jingjing Huang
Xiaoyang Hu
Duo Peng
Qiong Li
Yinuo Song
Dabing Zhang
- Publikationsdatum
- 01.06.2025
- Verlag
- Springer Vienna
- Erschienen in
-
Archives of Virology / Ausgabe 6/2025
Print ISSN: 0304-8608
Elektronische ISSN: 1432-8798 - DOI
- https://doi.org/10.1007/s00705-025-06307-4
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