Skip to main content
main-content

23.06.2018 | Short Communication

Identifying novel microhaplotypes for ancestry inference

Zeitschrift:
International Journal of Legal Medicine
Autoren:
Peng Chen, Wenjia Zhu, Fang Tong, Yan Pu, Youjia Yu, Shuainan Huang, Zheng Li, Lin Zhang, Weibo Liang, Feng Chen
Wichtige Hinweise

Electronic supplementary material

The online version of this article (https://​doi.​org/​10.​1007/​s00414-018-1881-x) contains supplementary material, which is available to authorized users.
Peng Chen and Wenjia Zhu contributed equally to this work.

Abstract

The use of DNA to determine the ancestry of an individual is becoming more and more important in the areas of forensics. Kidd et al. (Forensic Sci Int Genet 12:215–224, 2014) have been the first to identify and catalog haplotypes, termed as minihaplotypes (1–10-kilobase spans) and microhaplotypes (≤ 200 bp), with potential use in forensic analysis. In the present study, we selected 10 short ancestry informative microhaplotypes by calculating the informativeness (In) according to Rosenberg et al. (Am J Hum Genet 73(6):1402–1422, 2003). In total, 2504 individuals from 26 populations in 1000 Genomes Project database Phase 3 were enrolled. Among the studied microhaplotypes, eight of them are comprised of 3 SNPs while two microhaplotypes are made up of 4 SNPs. The size (molecular extent) range of 10 microhaplotypes is 5 to 48 bp with an average of 31.4 bp. The heterozygosity value ranges from 0.2235 to 0.8958 with an average of 0.6593. The average power of discrimination (PD) values is 0.7944 and ranges from 0.3786 to 0.9242. Analyses of this dataset provided clear differentiation of the populations from the Africa, East Asia, South Asia, and Europe biogeographic regions. However, individuals from American ancestry were not well separated. To conclude, our results revealed the significance of using microhaplotypes as an ancestry informative marker. The present panel could offer a valid complementary tool in forensic applications.

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

★ PREMIUM-INHALT
e.Med Interdisziplinär

Mit e.Med Interdisziplinär erhalten Sie Zugang zu allen CME-Fortbildungen und Premium-Inhalten der Fachzeitschriften, inklusive eines Print-Abos.

Zusatzmaterial
ESM 1 (DOCX 488 kb)
414_2018_1881_MOESM1_ESM.docx
Literatur
Über diesen Artikel

Neu im Fachgebiet Rechtsmedizin

26.06.2018 | Prostatakarzinom | CME | Ausgabe 4/2018

CME: Neuroendokrines Prostatakarzinom

19.06.2018 | Schwerpunkt: Pathologie und Forschungsbiobanken | Ausgabe 4/2018

Der Aufbau und Betrieb einer Zentralen Biomaterialbank

Die ZeBanC der Charité Berlin

06.06.2018 | Schwerpunkt: Pathologie und Forschungsbiobanken | Ausgabe 4/2018

Biobanking und die Weiterentwicklung der Präzisionsmedizin

23.05.2018 | Schwerpunkt: Pathologie und Forschungsbiobanken | Ausgabe 4/2018

Alle unter einem Dach

Erfolge und Herausforderungen auf dem Weg zu einer zentralisierten Biobank am Beispiel der BMBH