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01.12.2014 | Research | Ausgabe 1/2014 Open Access

Chinese Medicine 1/2014

Identifying roles of “Jun-Chen-Zuo-Shi” component herbs of QiShenYiQi formula in treating acute myocardial ischemia by network pharmacology

Chinese Medicine > Ausgabe 1/2014
Leihong Wu, Yi Wang, Zheng Li, Boli Zhang, Yiyu Cheng, Xiaohui Fan
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​1749-8546-9-24) contains supplementary material, which is available to authorized users.

Competing interests

The authors declare that they have no competing interests.

Authors’ contributions

XF, ZL, BZ and YC conceived and designed the study. YW performed the rat experiments. LW and XF analyzed the transcriptional data and performed network analysis. LW, XF and ZL wrote the manuscript. All the authors read and approved the final manuscript.



The role of “Jun-Chen-Zuo-Shi” (also known as “sovereign-minister-assistant-courier”) component herbs of Chinese medicine is not fully understood. This study aims to test the “Jun-Chen-Zuo-Shi” rule with the QiShenYiQi formula (QSYQ) on treating acute myocardial ischemia (AMI) by a network pharmacology approach.


An Acute Myocardial Ischemia (AMI) specific Organism Disturbed Network (AMI-ODN), was constructed by integrating data of disease-associated genes, protein-protein interaction and microarray experiments. A network-based index, Network Recovery Index for Organism Disturbed Network (NRI-ODN), was developed to measure the therapeutic efficacy of QSYQ and its ingredients, i.e., the ability to recover disturbed AMI network model back to normal state.


The whole formula of QSYQ got a NRI-ODN score of 864.48, which outperformed all individual herbs. Additionally, the primary component herbs, Radix Astragalus membranaceus and Radix Salvia miltiorrrhiza showed NRI-DON score of 680.27 and 734.31 respectively, which meant a better performance to recover disturbed AMI network than the supplementary component herbs, Panax notoginseng and Dalbergia sissoo did (545.76 and 584.88, respectively).


AMI-ODN model and NRI-ODN identified the possible roles of “Jun-Chen-Zuo-Shi” component herbs of QSYQ in treating AMI at molecular network and pathway level.
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