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Seminars in Immunopathology

Erschienen in:

14.09.2018 | Review

IgA nephropathy: clearance kinetics of IgA-containing immune complexes

verfasst von: Ann Chen, Sung-Sen Yang, Tsai-Jung Lin, Shuk-Man Ka

Erschienen in: Seminars in Immunopathology | Ausgabe 6/2018

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Abstract

IgA nephropathy (IgAN) is associated predominantly IgA deposition in the affected glomeruli and has been shown to be the most common glomerular disorder among young people in the world. Although the exact pathogenic mechanism underlying IgAN remains largely unknown, circulating IgA-containing immune complexes (IgA ICs) is considered to play a major role in initiating the development and evolution of the renal disorder. In this review article, we discuss the fundamental mechanisms of clearance kinetics of IgA ICs and related issues, covering the following: (1) role of circulating IgA ICs in the pathogenesis of IgAN and (2) elimination of IgA ICs from the body, with emphasis of the role of the liver and Fc receptors in immune cells.

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Titel: IgA nephropathy: clearance kinetics of IgA-containing immune complexes
verfasst von: Ann Chen
Sung-Sen Yang
Tsai-Jung Lin
Shuk-Man Ka
Publikationsdatum: 14.09.2018
Verlag: Springer Berlin Heidelberg
Erschienen in: Seminars in Immunopathology / Ausgabe 6/2018
Print ISSN: 1863-2297
Elektronische ISSN: 1863-2300
DOI: https://doi.org/10.1007/s00281-018-0708-7

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