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Erschienen in: Autoimmunity Highlights 1-2/2015

Open Access 01.08.2015 | Review Article

IgG4-related disease: case report and literature review

verfasst von: Abo-Helo Nizar, Elias Toubi

Erschienen in: Autoimmunity Highlights | Ausgabe 1-2/2015

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Abstract

IgG4-related disease (IgG4-RD) is relatively a new growing entity of immune-mediated origin, characterized by a mass-forming lesion, the infiltration of IgG4-positive plasma cells and occasionally elevated serum IgG4. It is considered to be both a systemic inflammation and sclerosing disease. The most common manifestations are parotid and lacrimal swelling, lymphadenopathy and autoimmune pancreatitis. Sclerosing cholangitis and retroperitoneal fibrosis are among the other mentioned frequent manifestations. The diagnosis should be approved histo-pathologically but other conditions such as lymphoma should be carefully excluded. Patients with IgG4-RD respond beneficially to glucocorticoid therapy especially when given at early onset stages. In some cases, the combination of immunosuppressive agents is required.
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Metadaten
Titel
IgG4-related disease: case report and literature review
verfasst von
Abo-Helo Nizar
Elias Toubi
Publikationsdatum
01.08.2015
Verlag
Springer International Publishing
Erschienen in
Autoimmunity Highlights / Ausgabe 1-2/2015
Print ISSN: 2038-0305
Elektronische ISSN: 2038-3274
DOI
https://doi.org/10.1007/s13317-015-0069-3

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