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Breast Cancer Research

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01.10.2002 | Commentary

IkB kinase alpha: a link in the chain of the mammary cycle

verfasst von: Richard Clarkson

Erschienen in: Breast Cancer Research | Ausgabe 5/2002

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Abstract

The transcription factor NF-κB exhibits altered activity in some breast cancers but the relevance of this association has not been established. Cao et al.'s elegant study recently published in Cell reveals a NF-κB-dependent signalling pathway responsible for epithelial proliferation in the mouse mammary gland. Could this mechanism, rather than prevention of apoptosis, be responsible for the reported association between NF-κB and breast cancer? Could the specificity of NF-κB modulators of the IkB kinase complex determine the fate of epithelial cells at different stages of mammary development?

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Titel: IkB kinase alpha: a link in the chain of the mammary cycle
verfasst von: Richard Clarkson
Publikationsdatum: 01.10.2002
Verlag: BioMed Central
Erschienen in: Breast Cancer Research / Ausgabe 5/2002
Elektronische ISSN: 1465-542X
DOI: https://doi.org/10.1186/bcr446

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