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Erschienen in: Rheumatology International 6/2014

01.06.2014 | Letter to the Editor

IL-32, a potential therapeutic target for rheumatoid arthritis?

verfasst von: Qiang Xie, Cheng Huang, Jian Zhong, Wen-Wen Shen, Shi-Cun Wang, Jun Li

Erschienen in: Rheumatology International | Ausgabe 6/2014

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Excerpt

Dear editor, …
Literatur
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Zurück zum Zitat Jung MY, Son MH, Kim SH et al (2011) IL-32gamma induces the maturation of dendritic cells with Th1- and Th17-polarizing ability through enhanced IL-12 and IL-6 production. J Immunol 186:6848–6859PubMedCrossRef Jung MY, Son MH, Kim SH et al (2011) IL-32gamma induces the maturation of dendritic cells with Th1- and Th17-polarizing ability through enhanced IL-12 and IL-6 production. J Immunol 186:6848–6859PubMedCrossRef
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Zurück zum Zitat Zivojinovic SM, Pejnovic NN, Sefik-Bukilica MN et al (2012) Tumor necrosis factor blockade differentially affects innate inflammatory and Th17 cytokines in rheumatoid arthritis. J Rheumatol 39:18–21PubMedCrossRef Zivojinovic SM, Pejnovic NN, Sefik-Bukilica MN et al (2012) Tumor necrosis factor blockade differentially affects innate inflammatory and Th17 cytokines in rheumatoid arthritis. J Rheumatol 39:18–21PubMedCrossRef
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Zurück zum Zitat Shoda H, Fujio K, Yamaguchi Y et al (2006) Interactions between IL-32 and tumor necrosis factor alpha contribute to the exacerbation of immune-inflammatory diseases. Arthritis Res Ther 8:R166PubMedCentralPubMedCrossRef Shoda H, Fujio K, Yamaguchi Y et al (2006) Interactions between IL-32 and tumor necrosis factor alpha contribute to the exacerbation of immune-inflammatory diseases. Arthritis Res Ther 8:R166PubMedCentralPubMedCrossRef
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Zurück zum Zitat Heinhuis B, Koenders MI, van de Loo FA et al (2011) Inflammation-dependent secretion and splicing of IL-32{gamma} in rheumatoid arthritis. Proc Natl Acad Sci USA 108:4962–4967PubMedCentralPubMedCrossRef Heinhuis B, Koenders MI, van de Loo FA et al (2011) Inflammation-dependent secretion and splicing of IL-32{gamma} in rheumatoid arthritis. Proc Natl Acad Sci USA 108:4962–4967PubMedCentralPubMedCrossRef
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Zurück zum Zitat Mun SH, Kim JW, Nah SS et al (2009) Tumor necrosis factor alpha-induced interleukin-32 is positively regulated via the Syk/protein kinase Cdelta/JNK pathway in rheumatoid synovial fibroblasts. Arthritis Rheum 60:678–685PubMedCrossRef Mun SH, Kim JW, Nah SS et al (2009) Tumor necrosis factor alpha-induced interleukin-32 is positively regulated via the Syk/protein kinase Cdelta/JNK pathway in rheumatoid synovial fibroblasts. Arthritis Rheum 60:678–685PubMedCrossRef
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Zurück zum Zitat Nakayama M, Niki Y, Kawasaki T et al (2012) Enhanced susceptibility to lipopolysaccharide-induced arthritis and endotoxin shock in interleukin-32 alpha transgenic mice through induction of tumor necrosis factor alpha. Arthritis Res Ther 14:R120PubMedCentralPubMedCrossRef Nakayama M, Niki Y, Kawasaki T et al (2012) Enhanced susceptibility to lipopolysaccharide-induced arthritis and endotoxin shock in interleukin-32 alpha transgenic mice through induction of tumor necrosis factor alpha. Arthritis Res Ther 14:R120PubMedCentralPubMedCrossRef
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Zurück zum Zitat Heinhuis B, Koenders MI, van Riel PL et al (2011) Tumour necrosis factor alpha-driven IL-32 expression in rheumatoid arthritis synovial tissue amplifies an inflammatory cascade. Ann Rheum Dis 70:660–667PubMedCrossRef Heinhuis B, Koenders MI, van Riel PL et al (2011) Tumour necrosis factor alpha-driven IL-32 expression in rheumatoid arthritis synovial tissue amplifies an inflammatory cascade. Ann Rheum Dis 70:660–667PubMedCrossRef
Metadaten
Titel
IL-32, a potential therapeutic target for rheumatoid arthritis?
verfasst von
Qiang Xie
Cheng Huang
Jian Zhong
Wen-Wen Shen
Shi-Cun Wang
Jun Li
Publikationsdatum
01.06.2014
Verlag
Springer Berlin Heidelberg
Erschienen in
Rheumatology International / Ausgabe 6/2014
Print ISSN: 0172-8172
Elektronische ISSN: 1437-160X
DOI
https://doi.org/10.1007/s00296-013-2780-6

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