Skip to main content
main-content

09.10.2015 | Original Article | Ausgabe 3/2016

Tumor Biology 3/2016

IL-6/NOS2 inflammatory signals regulate MMP-9 and MMP-2 activity and disease outcome in nasopharyngeal carcinoma patients

Zeitschrift:
Tumor Biology > Ausgabe 3/2016
Autoren:
Ahmed-Amine Zergoun, Abderezak Zebboudj, Sarah Leila Sellam, Nora Kariche, Djamel Djennaoui, Samir Ouraghi, Esma Kerboua, Zine-Charaf Amir-Tidadini, Dalia Chilla, Fatima Asselah, Chafia Touil-Boukoffa, Taha Merghoub, Mehdi Bourouba
Wichtige Hinweise

Highlights

• Plasma IL-6 correlates negatively with nitrite synthesis in cancer patients.
• In the NPC tumor microenvironment, IL-6 expression negatively correlates with NOS2 expression.
• Nitrite formation associates with MMP-9 activation, pro-MMP-2 expression, and inhibition of MMP-2 activation in cancer patients.
• Patients with high NOS activity have better RFS than patients with low/moderate NOS activity.

Abstract

The role of nitric oxide (NO)· in the development of the metastatic properties of nasopharyngeal carcinoma (NPC) is not fully understood. Previous studies proposed that interleukin-6 (IL-6) would act as regulator of matrix metalloprotease activation in NPC. Recently, we showed that (NO)· was a critical mediator of tumor growth in patients. The aim of this study was to determine the implication of IL-6 in the progression of NPC pathology via metalloprotease (MMP) activation and their possible correlation with (NO)· production. We observed a significant increase in IL-6 and nitrite (NO2 ) synthesis in patients (n = 17) as well as a strong expression of IL-6 and nitric oxide synthase 2 (NOS2) in the analyzed tumors (n = 8). In patients’ plasma, a negative correlation associated IL-6 with circulating nitrites (r = −0.33). A negative correlation associated the H-scores of these signals in the tumors (r = −0.47). In patients’ plasma, nitrite synthesis was positively associated with MMP-9 activation (r = 0.45), pro-MMP-2 expression (r = 0.37), and negatively correlated with MMP-2 activation (r = −0.51). High nitrite levels was associated with better recurrence-free survival (RFS) (p = 0.02). Overall, our results suggest that the IL-6/NOS2 inflammatory signals are involved in the regulation of MMP-9- and MMP-2-dependent metastatic activity and that high circulating nitrite levels in NPC patients may constitute a prognostic predictor for survival.

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

★ PREMIUM-INHALT
e.Med Interdisziplinär

Mit e.Med Interdisziplinär erhalten Sie Zugang zu allen CME-Fortbildungen und Fachzeitschriften auf SpringerMedizin.de. Zusätzlich können Sie eine Zeitschrift Ihrer Wahl in gedruckter Form beziehen – ohne Aufpreis.

Bis zum 22.10. bestellen und 100 € sparen!

Weitere Produktempfehlungen anzeigen
Literatur
Über diesen Artikel

Weitere Artikel der Ausgabe 3/2016

Tumor Biology 3/2016 Zur Ausgabe
  1. Das kostenlose Testabonnement läuft nach 14 Tagen automatisch und formlos aus. Dieses Abonnement kann nur einmal getestet werden.