Background
Methods
Subjects
Genotyping
Statistical analysis
Results
The distribution of IL17A and IL17F genotypes and alleles
RA patients | Control group |
p
a
|
p
b
| OR (95 % CI) | ||||
---|---|---|---|---|---|---|---|---|
n
| % |
n
| % | |||||
IL17A rs2275913 genotype | ||||||||
GG | 173 | 41.49 | 118 | 35.01 | 0.17 | AA + AG vs GG | 0.072 | 0.76 (0.56-1.02) |
AG | 193 | 46.28 | 169 | 50.15 | AA vs AG + GG | 0.33 | 0.80 (0.53-1.22) | |
AA | 51 | 12.23 | 50 | 14.84 | AA vs GG | 0.13 | 0.70 (0.44-1.10) | |
AG vs GG | 0.13 | 0.78 (0.57-1.06) | ||||||
AA vs AG | 0.65 | 0.89 (0.57-1.39) | ||||||
IL17A rs2275913 allele | ||||||||
G | 539 | 64.63 | 405 | 60.09 | ||||
A | 295 | 35.37 | 269 | 39.91 | A vs G | 0.077 | 0.82 (0.67-1.02) | |
IL17F rs763780 genotype | ||||||||
TT | 385 | 91.23 | 318 | 94.08 | 0.33 | CC + CT vs TT | 0.17 | 1.53 (0.87-2.69) |
CT | 35 | 8.29 | 19 | 5.62 | CC vs CT + TT | 1.00 | 1.60 (0.14-17.77) | |
CC | 2 | 0.47 | 1 | 0.30 | CC vs TT | 1.00 | 1.65 (0.15-18.30) | |
CT vs TT | 0.16 | 1.52 (0.85-2.71) | ||||||
CC vs CT | 1.00 | 1.09 (0.09-12.77) | ||||||
IL17F rs763780 allele | ||||||||
T | 805 | 95.38 | 655 | 96.89 | ||||
C | 39 | 4.62 | 21 | 3.11 | C vs T | 0.15 | 1.51 (0.88-2.59) | |
IL17F rs11465553 genotype | ||||||||
CC | 379 | 89.81 | 303 | 89.64 | 0.96 | TT + CT vs CC | 1.00 | 0.98 (0.61-1.57) |
CT | 43 | 10.19 | 35 | 10.36 | TT vs CT + CC | - | ||
TT | 0 | 0.00 | 0 | 0.00 | TT vs CC | - | ||
CT vs CC | 1.00 | 0.98 (0.61-1.57) | ||||||
TT vs CT | - | |||||||
IL17F rs11465553 allele | ||||||||
C | 801 | 94.91 | 641 | 94.82 | ||||
T | 43 | 5.09 | 35 | 5.18 | T vs C | 1.00 | 0.98 (0.62-1.55) | |
IL17F rs2397084 genotype | ||||||||
TT | 337 | 79.86 | 268 | 79.29 | 0.13 | CC + CT vs TT | 0.86 | 0.97 (0.68-1.38) |
CT | 83 | 19.67 | 63 | 18.64 | CC vs CT + TT | 0.086 | 0.23 (0.05-1.09) | |
CC | 2 | 0.47 | 7 | 2.07 | CC vs TT | 0.086 | 0.23 (0.05-1.10) | |
CT vs TT | 0.85 | 1.05 (0.73-1.51) | ||||||
CC vs CT | 0.079 | 0.22 (0.04-1.08) | ||||||
IL17F rs2397084 allele | ||||||||
T | 757 | 89.69 | 599 | 88.61 | ||||
C | 87 | 10.31 | 77 | 11.39 | C vs T | 0.51 | 0.89 (0.65-1.24) |
The parameters of clinical course of RA
Genotype | Age of disease diagnosis | Rheumatoid Factor positive | Erosive RA | Extra-articular manifestations | |||||
---|---|---|---|---|---|---|---|---|---|
Mean [years] | SD |
p
a
| (%) |
p
b
| (%) |
p
b
| (%) |
p
b
| |
IL17A rs2275913 | |||||||||
GG | 46.6 | 13.3 | 0.56 | 72.02 | 0.35 | 80.23 | 0.64 | 14.45 | 0.25 |
AG | 48.1 | 13.2 | 78.61 | 81.87 | 19.69 | ||||
AA | 46.6 | 12.8 | 74.00 | 76.00 | 11.76 | ||||
IL17F rs763780 | |||||||||
TT | 47.3 | 13.2 | 0.69 | 75.60 | 0.70 | 80.16 | 0.52 | 16.10 | 0.14 |
CT | 49.0 | 12.2 | 74.29 | 82.86 | 28.57 | ||||
CC | 44.5 | 33.2 | 50.00 | 50.00 | 0.00 | ||||
IL17F rs11465553 | |||||||||
CC | 47.5 | 13.4 | 0.63 | 75.27 | 1.00 | 79.84 | 0.69 | 18.21 | 0.084 |
CT | 46.7 | 12.0 | 76.19 | 83.72 | 6.98 | ||||
IL17F rs2397084 | |||||||||
TT | 47.6 | 13.1 | 0.69 | 75.08 | 0.04*
| 80.06 | 0.78 | 16.62 | 0.69 |
CT | 46.4 | 14.0 | 78.48 | 80.49 | 19.28 | ||||
CC | 50.5 | 6.4 | 0.00 | 100.00 | 0.00 |
Haplotype analysis
Locus 1 | Locus 2 | D’ |
r
2
| Distance (bp) |
---|---|---|---|---|
rs2275913 | rs763780 | 0.897 | 0.02 | 50706 |
rs2275913 | rs11465553 | 0.839 | 0.023 | 50725 |
rs2275913 | rs2397084 | 0.587 | 0.025 | 50811 |
rs763780 | rs11465553 | 1 | 0.002 | 19 |
rs763780 | rs2397084 | 1 | 0.005 | 105 |
rs11465553 | rs2397084 | 1 | 0.007 | 86 |
Haplotype | Frequencies |
p* | |
---|---|---|---|
RA | Control | ||
GTCT | 0.464 | 0.424 | 0.12 |
ATCT | 0.336 | 0.379 | 0.08 |
GTCC | 0.089 | 0.097 | 0.60 |
GTTT | 0.048 | 0.049 | 0.93 |
GCCT | 0.045 | 0.031 | 0.16 |
ATCC | 0.014 | 0.017 | 0.61 |
ACCT | 0.002 | 0.003 | 0.81 |