PH is an extremely rare benign disease of the pancreas. To the best of our knowledge, only 37 cases have been reported in the English literature. This disease may occur at any age. The youngest patient reported was a premature female infant who died of a trisomy 18 karyotype deformity after less than one hour of life [
20], while the oldest patient reported was a 78-year-old woman [
12]. The average age of diagnosis was approximately 51 years, and no gender predilection has been reported in the literature [
2‐
24]. Several patients had concomitant abdominal or back discomfort, indigestion and weight loss [
5‐
7,
10,
15,
19], while the majority of patients were asymptomatic. This benign tumour was often located in the head of the pancreas, and the rate was approximately 62% (23/37) [
24]. Dilation of the main pancreatic duct (MPD) and bile duct or signs of jaundice were rare. Only three cases showed biliary or pancreatic duct obstruction [
3,
17]. Consistent with the previous findings, our cases were diagnosed in elderly patients, occurred in the pancreatic head and were asymptomatic, with no dilation of duct. Most of these tumours were solitary, as only one case with three well-demarcated solid nodules in the head of the pancreas has been reported [
12]. PH is usually divided into two subgroups: solid lesion types or solid and cystic lesion types, with no significant differences in the ratio (20/17). Case 1 was a solid lesion with small cystic lesions, and case 2 was a solid lesion. This tumour is characterized by soft tissue masses of different sizes (ranging from 0.3 to 14 cm), while over 50% of cases (29/37) were no more than 3 cm [
6,
7,
9‐
13,
15‐
24]. On US, PH is usually observed as a hypoechoic mass with a clear boundary [
11,
17,
19,
21]. On CT, the mass is usually well defined, and the internal density of most of the solid lesions is slightly uneven, with low iso-intensity and heterogeneous progressive contrast enhancement in the delayed phase [
9,
13]. Additionally, the borders are typically well-defined after contrast enhancement [
9,
22]. Similar to previous reports, our cases had heterogenous internal content, with obvious progressive enhancement. This observation is different from pancreatic adenocarcinoma and pancreatic neuroendocrine tumor. Pancreatic adenocarcinoma is characterized by low enhancement and surrounding structure invasion, and pancreatic neuroendocrine tumor by obvious enhancement at early phase after contrast administration. On MRI, the shape of PH lesions was often regular, and the boundary was clear on T2WI. The internal intensity was slightly uneven, T1WI showed low-intensity, T2WI showed iso- to high-intensity [
12,
19,
21,
22], and DWI showed iso-intensity [
21]. Similarly, our two cases showed iso-intensity on DWI, which is different from some kinds of pancreatic tumours with hyperintensity. For the pathological examination, there were many glandular ducts in the tumour, which might be related to the iso-intensity on DWI. The enhancement patterns were progressive and obvious enhancement in the portal phase or delayed phase was observed [
9,
12,
13,
16,
22]. Our imaging features were consistent with those findings in the literature; therefore, it is suggested that the DWI and enhancement pattern are the most important features to indicate PH. On positron emission tomography (PET)-CT, some reports have shown that pancreatic hamartoma has normal 18F-fluorodeoxyglucose (FDG) accumulation [
6,
12,
22]. However, Nagano’s research [
21] showed lesion uptake of 18F-FDG with a maximum standardized uptake value (SUVmax) of 3.6 at early imaging (1 h), which increased to 5.0 on the delayed imaging, which made it difficult to differentiate pancreatic hamartoma from malignant tumours. In terms of the tumour capsule, there are still some controversies in the literature: some reports have shown the presence of capsules in PH [
16,
18,
19,
24], while others have not [
7,
9,
13,
22]. Unfortunately, the studies that reported tumour capsules did not show the imaging findings. Some reports showed that several cases had some lipomatous components [
18,
24] or calcification [
6], but this was very rare. PH is a benign tumour, and no recurrence has been reported. To date, the two patients presented here have been followed for 34 and 44 months, respectively, and have remained disease free. Even though PH is benign, it is difficult to diagnose via imaging. Most patients undergo surgical resection because of the possibility of malignant disease. Thus, useful information from imaging would help to select the best treatment.
Pancreatic hamartoma is an extremely rare and benign tumour of the pancreas. Clinical diagnosis based on imaging remains difficulty. We suggest that the observation of “well-demarcated lesion in the head of pancreas, with no dilatation of the MPD, slightly hyperintensity or iso-intensity on T2WI, iso-intensity on DWI, and obvious progressive enhancement patterns” may help in diagnosis of PH and prevent unnecessary surgery for patients with this diagnosis.