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23.11.2016 | Research Article | Ausgabe 5/2017

Clinical and Translational Oncology 5/2017

Imaging findings of adrenal primitive neuroectodermal tumors: a series of seven cases

Clinical and Translational Oncology > Ausgabe 5/2017
Y. Zhang, P. Cai, M. Chen, X. Yi, L. Li, D. Xiao, W. Liu, W. Li, Y. Li
Wichtige Hinweise
Y. Zhang, P. Cai and M. Chen contributed equally to this work.



To explore the imaging features of adrenal primitive neuroectodermal tumors (PNETs).

Materials and methods

This retrospective study included seven patients with surgically and pathologically confirmed adrenal PNETs. Among them, six underwent computed tomography (CT) scans, and one underwent magnetic resonance imaging. The imaging findings, including size, shape, margin, hemorrhage, calcification, cystic degeneration, regional lymph nodes involvement, tumor thrombus formation and enhancement pattern, were retrospectively analyzed.


Among the seven adrenal PNET patients, six were male, and one was female. The median age was 26 years (range 2–56 years). The disease generally presented with either insidious symptoms (n = 4) or non-specific symptoms, including right flank pain (n = 1) and left upper abdominal discomfort (n = 2). On the pre-enhanced CT images, the tumor usually appeared as a well-defined, rounded or oval, heterogeneous mass without calcification. Certain tissue characteristics, such as cystic degeneration (n = 5), capsule (n = 4) and hemorrhage (n = 2), were observed. Regional lymph node involvement was observed in three cases, and renal vein thrombus was observed in one case. All cases showed mild heterogeneous enhancement of the tumor on the enhanced CT images.


An adrenal PNET commonly presents as a relatively large, well-defined, heterogeneous mass with cystic degeneration, necrosis and a characteristic mild contrast-enhancement pattern on multiphase enhanced images. PNET should be considered when the diagnosis of common tumors is not favored by signs on images.

Clinical Trial Registration Statement

This study was approved by the medical ethics committee of Xiangya Hospital, Central South University. The approval number is 201512538.

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