Skip to main content
main-content
Erschienen in: Forensic Toxicology 2/2011

01.07.2011 | Original Article

Imaging of methamphetamine incorporated into hair by MALDI-TOF mass spectrometry

verfasst von: Akihiro Miki, Munehiro Katagi, Noriaki Shima, Hiroe Kamata, Michiaki Tatsuno, Toyofumi Nakanishi, Hitoshi Tsuchihashi, Takayuki Takubo, Koichi Suzuki

Erschienen in: Forensic Toxicology | Ausgabe 2/2011

Einloggen, um Zugang zu erhalten

Abstract

Matrix-assisted laser desorption ionization (MALDI)–time-of-flight (TOF) mass spectrometry (MS) was used for visual demonstration of methamphetamine (MA) incorporation into human hair. Longitudinal sections of human scalp hair shafts from chronic MA users were directly subjected to imaging MS. Numerous MA-positive spots with various intensities were observed in the specimens, which probably reflect habitual MA abuse and the different MA blood levels upon each administration. This imaging MS method for drugs in hair seems to give much more accurate chronological information on drug use, and clearer discrimination between deliberate drug use and passive exposure, using only a single hair shaft. This is the first report of imaging MS applied to forensic toxicology. This method is expected open a new field in analyses of drugs in hair.
Literatur
1.
Zurück zum Zitat United Nations Office on Drugs and Crime (2010) World drug report 2010. United Nations Publication, New York United Nations Office on Drugs and Crime (2010) World drug report 2010. United Nations Publication, New York
2.
Zurück zum Zitat National Police Agency (2009) The white paper on police 2009. National Police Agency, Tokyo National Police Agency (2009) The white paper on police 2009. National Police Agency, Tokyo
3.
Zurück zum Zitat Kintz P, Spiehler V, Negrusz A (2008) Alternative specimens. In: Jickells S, Negrusz A (eds) Clark’s analytical forensic toxicology. Pharmaceutical Press, London, pp 153–190 Kintz P, Spiehler V, Negrusz A (2008) Alternative specimens. In: Jickells S, Negrusz A (eds) Clark’s analytical forensic toxicology. Pharmaceutical Press, London, pp 153–190
4.
Zurück zum Zitat Huestis MA (1996) Technical and legal aspects of drugs of abuse testing in hair. In: Kintz P (ed) Drug testing in hair. CRC Press, New York, pp 5–16 Huestis MA (1996) Technical and legal aspects of drugs of abuse testing in hair. In: Kintz P (ed) Drug testing in hair. CRC Press, New York, pp 5–16
5.
Zurück zum Zitat Miki A, Katagi M, Tsuchihashi H (2003) Recent improvements in forensic hair analysis for illicit drugs. J Health Sci 49:325–332 CrossRef Miki A, Katagi M, Tsuchihashi H (2003) Recent improvements in forensic hair analysis for illicit drugs. J Health Sci 49:325–332 CrossRef
6.
Zurück zum Zitat Miki A, Katagi M, Zaitsu K, Nishioka H, Tsuchihashi H (2008) Development of a two-step injector for GC–MS with on-column derivatization, and its application to the determination of amphetamine-type stimulants (ATS) in biological specimens. J Chromatogr B 865:25–32 CrossRef Miki A, Katagi M, Zaitsu K, Nishioka H, Tsuchihashi H (2008) Development of a two-step injector for GC–MS with on-column derivatization, and its application to the determination of amphetamine-type stimulants (ATS) in biological specimens. J Chromatogr B 865:25–32 CrossRef
7.
Zurück zum Zitat Miki A, Katagi M, Tsuchihashi H (2003) Determination of methamphetamine and its metabolites incorporated in hair by column-switching liquid chromatography–mass spectrometry. J Anal Toxicol 27:95–102 PubMed Miki A, Katagi M, Tsuchihashi H (2003) Determination of methamphetamine and its metabolites incorporated in hair by column-switching liquid chromatography–mass spectrometry. J Anal Toxicol 27:95–102 PubMed
8.
Zurück zum Zitat Harun N, Anderson RA, Cormack PA (2010) Analysis of ketamine and norketamine in hair samples using molecularly imprinted solid-phase extraction (MISPE) and liquid chromatography-tandem mass spectrometry (LC-MS/MS). Anal Bioanal Chem 396:2449–2459 PubMedCrossRef Harun N, Anderson RA, Cormack PA (2010) Analysis of ketamine and norketamine in hair samples using molecularly imprinted solid-phase extraction (MISPE) and liquid chromatography-tandem mass spectrometry (LC-MS/MS). Anal Bioanal Chem 396:2449–2459 PubMedCrossRef
9.
Zurück zum Zitat Nakahara Y, Shimamine M, Takahashi K (1992) Hair analysis for drugs of abuse. III. Movement and stability of methoxyphenamine (as a model compound of methamphetamine) along hair shaft with hair growth. J Anal Toxicol 16:253–257 PubMed Nakahara Y, Shimamine M, Takahashi K (1992) Hair analysis for drugs of abuse. III. Movement and stability of methoxyphenamine (as a model compound of methamphetamine) along hair shaft with hair growth. J Anal Toxicol 16:253–257 PubMed
10.
Zurück zum Zitat Nakahara Y, Takahashi K, Shimamine M, Takeda Y (1991) Hair analysis for drug abuse: I. Determination of methamphetamine and amphetamine in hair by isotope dilution gas chromatography/mass spectrometry method. J Forensic Sci 36:70–78 PubMed Nakahara Y, Takahashi K, Shimamine M, Takeda Y (1991) Hair analysis for drug abuse: I. Determination of methamphetamine and amphetamine in hair by isotope dilution gas chromatography/mass spectrometry method. J Forensic Sci 36:70–78 PubMed
11.
Zurück zum Zitat Jackson SN, Ugarov M, Egan T, Post JD, Langlais D, Schultz JA, Woods AS (2007) MALDI-ion mobility-TOFMS imaging of lipids in rat brain tissue. J Mass Spectrom 42:1093–1098 PubMedCrossRef Jackson SN, Ugarov M, Egan T, Post JD, Langlais D, Schultz JA, Woods AS (2007) MALDI-ion mobility-TOFMS imaging of lipids in rat brain tissue. J Mass Spectrom 42:1093–1098 PubMedCrossRef
12.
Zurück zum Zitat Groseclose MR, Andersson M, Hardesty WM, Caprioli RM (2007) Identification of proteins directly from tissue: in situ tryptic digestions coupled with imaging mass spectrometry. J Mass Spectrom 42:254–262 PubMedCrossRef Groseclose MR, Andersson M, Hardesty WM, Caprioli RM (2007) Identification of proteins directly from tissue: in situ tryptic digestions coupled with imaging mass spectrometry. J Mass Spectrom 42:254–262 PubMedCrossRef
13.
Zurück zum Zitat Wang HY, Jackson SN, McEuen J, Woods AS (2005) Localization and analyses of small drug molecules in rat brain tissue sections. Anal Chem 77:6682–6686 PubMedCrossRef Wang HY, Jackson SN, McEuen J, Woods AS (2005) Localization and analyses of small drug molecules in rat brain tissue sections. Anal Chem 77:6682–6686 PubMedCrossRef
14.
Zurück zum Zitat Vogliardi S, Favretto D, Frison G, Ferrara SD, Seraglia R, Traldi P (2009) A fast screening MALDI method for the detection of cocaine and its metabolites in hair. J Mass Spectrom 44:18–24 PubMedCrossRef Vogliardi S, Favretto D, Frison G, Ferrara SD, Seraglia R, Traldi P (2009) A fast screening MALDI method for the detection of cocaine and its metabolites in hair. J Mass Spectrom 44:18–24 PubMedCrossRef
15.
Zurück zum Zitat Vogliardi S, Favretto D, Frison G, Maietti S, Viel G, Seraglia R, Traldi P, Ferrara SD (2010) Validation of a fast screening method for the detection of cocaine in hair by MALDI–MS. Anal Bioanal Chem 396:2435–2440 PubMedCrossRef Vogliardi S, Favretto D, Frison G, Maietti S, Viel G, Seraglia R, Traldi P, Ferrara SD (2010) Validation of a fast screening method for the detection of cocaine in hair by MALDI–MS. Anal Bioanal Chem 396:2435–2440 PubMedCrossRef
16.
Zurück zum Zitat Miki A, Katagi M, Tsuchihashi H (2002) Application of EMIT ® d.a.u.™ for the semiquantitative screening of methamphetamine incorporated in hair. J Anal Toxicol 26:274–279 PubMed Miki A, Katagi M, Tsuchihashi H (2002) Application of EMIT ® d.a.u.™ for the semiquantitative screening of methamphetamine incorporated in hair. J Anal Toxicol 26:274–279 PubMed
17.
Zurück zum Zitat Nakahara Y (1995) Detection and diagnostic interpretation of amphetamines in hair. Forensic Sci Int 70:135–153 PubMedCrossRef Nakahara Y (1995) Detection and diagnostic interpretation of amphetamines in hair. Forensic Sci Int 70:135–153 PubMedCrossRef
18.
Zurück zum Zitat Kidwell DA, Blank DL (1996) Environmental exposure–the stumbling block of hair testing. In: Kintz P (ed) Drug testing in hair. CRC Press, New York, pp 17–68 Kidwell DA, Blank DL (1996) Environmental exposure–the stumbling block of hair testing. In: Kintz P (ed) Drug testing in hair. CRC Press, New York, pp 17–68
Metadaten
Titel
Imaging of methamphetamine incorporated into hair by MALDI-TOF mass spectrometry
verfasst von
Akihiro Miki
Munehiro Katagi
Noriaki Shima
Hiroe Kamata
Michiaki Tatsuno
Toyofumi Nakanishi
Hitoshi Tsuchihashi
Takayuki Takubo
Koichi Suzuki
Publikationsdatum
01.07.2011
Verlag
Springer Japan
Erschienen in
Forensic Toxicology / Ausgabe 2/2011
Print ISSN: 1860-8965
Elektronische ISSN: 1860-8973
DOI
https://doi.org/10.1007/s11419-011-0109-2

Weitere Artikel der Ausgabe 2/2011

Forensic Toxicology 2/2011 Zur Ausgabe

Neu im Fachgebiet Rechtsmedizin

Open Access 15.08.2022 | Mammakarzinom | CME

Prädiktive molekulare Diagnostik beim Mammakarzinom

Welche Anforderungen stellen sich heute und in Zukunft für die Pathologie?

10.08.2022 | Schwerpunkt: Akkreditierung und Zertifizierung (Qualitätssicherung)

Ringversuche – ein zentrales Mittel der externen Qualitätssicherung

03.08.2022 | Schwerpunkt: Akkreditierung und Zertifizierung (Qualitätssicherung)

Akkreditierung in der Pathologie und Neuropathologie

Wege und Pitfalls

25.07.2022 | Schwerpunkt: Akkreditierung und Zertifizierung (Qualitätssicherung)

Die Akkreditierung in der Pathologie und Neuropathologie in Deutschland

Rahmenbedingungen und Voraussetzungen