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01.09.2009 | Leitthema

Immundefekte mit selektiver Vulnerabilität für einzelne Erreger

verfasst von: V. Schuster, Dr. H. von Bernuth

Erschienen in: Monatsschrift Kinderheilkunde | Ausgabe 9/2009

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Zusammenfassung

Klassische angeborene Immundefekte prädisponieren zu wiederholten, oft polytopen schweren Infektionen durch multiple opportunistische Erreger. In den letzten 10 Jahren sind auch genetisch bedingte Immundefekte mit selektiver Anfälligkeit für Infektionen durch einzelne Erregergruppen oder einzelne Erreger identifiziert worden. Hierzu gehören Immundefekte mit Prädisposition für Infektionen durch Mykobakterien und Salmonellen, für invasive bakterielle Infektionen, für Herpes-simplex-Enzephalitis, für durch Epstein-Barr-Virus induzierte lymphoproliferative Krankheitsbilder und für schwere Infektionen durch Papillomaviren. Die folgende Übersicht stellt Genetik, Pathophysiologie, klinisches Bild, Differenzialdiagnosen, diagnostisches Vorgehen, Prognose und Therapieoptionen dieser „neuen“ Immundefekte dar.

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Titel: Immundefekte mit selektiver Vulnerabilität für einzelne Erreger
verfasst von: V. Schuster
Dr. H. von Bernuth
Publikationsdatum: 01.09.2009
Verlag: Springer-Verlag
Erschienen in: Monatsschrift Kinderheilkunde / Ausgabe 9/2009
Print ISSN: 0026-9298
Elektronische ISSN: 1433-0474
DOI: https://doi.org/10.1007/s00112-009-1989-7

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