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Seminars in Immunopathology

Erschienen in:

11.04.2017 | Review

Immune-mediated cytokine storm and its role in severe dengue

verfasst von: Anon Srikiatkhachorn, Anuja Mathew, Alan L. Rothman

Erschienen in: Seminars in Immunopathology | Ausgabe 5/2017

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Abstract

Dengue remains one of the most important mosquito-borne diseases worldwide. Infection with one of the serologically related dengue viruses (DENVs) can lead to a wide range of clinical manifestations and severity. Severe dengue is characterized by plasma leakage and abnormal bleeding that can lead to shock and death. There is currently no specific treatment for severe dengue due to gaps in understanding of the underlying mechanisms. The transient period of vascular leakage is usually followed by a rapid recovery and is suggestive of the effects of short-lived biological mediators. Both the innate and the adaptive immune systems are activated in severe dengue and contribute to the cytokine production. We discuss the immunological events elicited during a DENV infection and identify candidate cytokines that may play a key role in the severe manifestations of dengue and possible interventions.

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Titel: Immune-mediated cytokine storm and its role in severe dengue
verfasst von: Anon Srikiatkhachorn
Anuja Mathew
Alan L. Rothman
Publikationsdatum: 11.04.2017
Verlag: Springer Berlin Heidelberg
Erschienen in: Seminars in Immunopathology / Ausgabe 5/2017
Print ISSN: 1863-2297
Elektronische ISSN: 1863-2300
DOI: https://doi.org/10.1007/s00281-017-0625-1

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