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01.01.2012 | Original Article

Immune response as a possible mechanism of long-lasting disease control in spontaneous remission of MLL/AF9-positive acute myeloid leukemia

verfasst von: Claudia Müller-Schmah, Leticia Solari, Roland Weis, Dietmar Pfeifer, Carmen Scheibenbogen, Martin Trepel, Annette M. May, Rupert Engelhardt, Michael Lübbert

Erschienen in: Annals of Hematology | Ausgabe 1/2012

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Abstract

Spontaneous complete remission (CR) is a rare, poorly understood phenomenon in acute myeloid leukemia (AML). We describe the 10-year follow-up of a patient with MLL-AF9-positive AML (Müller et al. Eur J Haematol 73:62–66, 2004), including ex vivo antileukemic immune responses which may contribute to the long-lasting spontaneous CR (tantamount to cure). We could demonstrate strong in vitro cytotoxic activity mediated by the patient’s serum (cryopreserved at diagnosis 2001) against myeloid cell lines. We also addressed cellular cytotoxic activity against myeloid leukemia cells. When the patient’s natural killer (NK) cells (obtained in 2007) were tested against the K562 cell line, upregulation of CD107 occurred, implying that long-term CR in this patient could be due to NK cell-mediated disease control.

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Titel: Immune response as a possible mechanism of long-lasting disease control in spontaneous remission of MLL/AF9-positive acute myeloid leukemia
verfasst von: Claudia Müller-Schmah
Leticia Solari
Roland Weis
Dietmar Pfeifer
Carmen Scheibenbogen
Martin Trepel
Annette M. May
Rupert Engelhardt
Michael Lübbert
Publikationsdatum: 01.01.2012
Verlag: Springer-Verlag
Erschienen in: Annals of Hematology / Ausgabe 1/2012
Print ISSN: 0939-5555
Elektronische ISSN: 1432-0584
DOI: https://doi.org/10.1007/s00277-011-1332-y

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Immune response as a possible mechanism of long-lasting disease control in spontaneous remission of MLL/AF9-positive acute myeloid leukemia

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