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01.12.2012 | Research | Ausgabe 1/2012 Open Access

Malaria Journal 1/2012

Immunoglobulins against the surface of Plasmodium falciparum- infected erythrocytes increase one month after delivery

Zeitschrift:
Malaria Journal > Ausgabe 1/2012
Autoren:
Alfredo Mayor, Elisa Serra-Casas, Eduard Rovira-Vallbona, Alfons Jiménez, Llorenç Quintó, Betuel Sigaúque, Carlota Dobaño, Azucena Bardají, Pedro L Alonso, Clara Menéndez
Wichtige Hinweise

Competing interests

The authors have no commercial or other association that may pose a conflict of interest.

Authors’ contributions

AM conceived the study, performed the statistical analysis and drafted the manuscript; ES and AJ carried out the immunological and molecular determinations; LQ participated in the statistical analysis; ERV, CD and AB participated in the interpretation of results and the drafting of the manuscript; BS participated in the acquisition of data; PLA and CM contributed to the interpretation of the results and the drafting of the manuscript. All authors have read and approved the manuscript.

Abstract

Background

The risk of Plasmodium falciparum malaria increases during pregnancy and at early postpartum. Immunological and physiological alterations associated with pregnancy that persist after delivery may contribute to the susceptibility to P. falciparum during early postpartum period.

Methods

To determine changes in antibody-mediated responses after pregnancy, levels of Immunoglobulin G (IgGs) specific for P. falciparum were compared in 200 pairs of plasmas collected from Mozambican women at delivery and during the first two months postpartum. IgGs against the surface of erythrocytes infected with a P. falciparum chondroitin sulphate A binding line (CS2) and a paediatric isolate (MOZ2) were measured by flow cytometry.

Results

IgG levels against CS2 and MOZ2 were higher at postpartum than at delivery (p = 0.033 and p = 0.045, respectively) in women without P. falciparum infection. The analysis stratified by parity and period after delivery showed that this increase was significant in multi-gravid women (p = 0.023 for CS2 and p = 0.054 for MOZ2) and during the second month after delivery (p = 0.018 for CS2 and p = 0.015 for MOZ2).

Conclusions

These results support the view that early postpartum is a period of recovery from physiological or immunological changes associated with pregnancy.
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