Introduction
Materials and methods
Patients
Immunohistochemistry (IHC)
TP53 mutation status
Scoring
Statistics
Data analysis
Multivariate analysis
Results and discussion
Staining of PLK1 in breast tumour samples
Parameter | PLK1 | Staining | P-value | Odds Ratio | |
---|---|---|---|---|---|
Pos (N(%)) | Neg (N(%)) | ||||
N | 23 (10.7) | 192 (89.3) | - | - | |
P53 mutational status | mutant | 12 (5.6) | 46 (21.4) | 0.0063 | 3.46 |
wild type | 11 (5.1) | 146 (67.9) | |||
unknown | 0 | 0 | |||
Histological Grade | 1 to 2 | 2 (1.0) | 108 (51.2) | < 0.001 | 14.18 |
3 | 21 (10.0) | 80 (37.9) | |||
unknown | 0 | 4 | |||
Survival | dead | 9 (4.2) | 37 (15.8) | 0.02 (Log Rank) | 2.318 (HR) |
alive | 14 (6.5) | 155 (73.5) | |||
unknown | 0 | 0 | |||
Menopause | pre-peri | 8 (3.9) | 42 (20.2) | 0.1861 | 1.96 |
post | 14 (6.7) | 144 (69.2) | |||
unknown | 1 | 6 | |||
Lymph Node Status | positive | 12 (5.7) | 90 (42.7) | 0.8257 | 1.19 |
negative | 11 (5.2) | 98 (46.5) | |||
unknown | 0 | 4 | |||
Size | < 2 cm | 17 (7.9) | 138 (64.2) | 1 | 1.11 |
>/ = 2 cm | 6 (2.8) | 54 (25.1) | |||
unknown | 0 | 0 | |||
Luminal A | positive | 7 (3.3) | 99 (47.1) | 0.075 | 0.42 |
negative | 15 (7.1) | 90 (42.4) | |||
unknown | 1 | 3 | |||
Luminal B | positive | 2 (1.0) | 37 (17.6) | 0.382 | 0.41 |
negative | 20 (9.5) | 152 (71.9) | |||
unknown | 1 | 3 | |||
HER2 | positive | 5 (2.4) | 28 (12.9) | 0.344 | 1.76 |
negative | 17 (8.1) | 162 (76.7) | |||
unknown | 1 | 2 | |||
ER-alpha | positive | 12 (5.6) | 151 (70.6) | 0.0081 | 3.46 |
negative | 11 (5.1) | 40 (18.7) | |||
unknown | 0 | 1 | |||
PR | positive | 10 (4.7) | 110 (51.4) | 0.266 | 0.57 |
negative | 13 (6.1) | 81 (37.9) | |||
unknown | 0 | 1 | |||
Triple negative | yes | 8 (3.8) | 25 (11.9) | 0.010 | 3.8 |
no | 14 (6.7) | 164 (77.6) | |||
unknown | 1 | 3 | |||
MDM2 | positive | 10 (4.7) | 31 (14.5) | 0.004 | 3.95 |
negative | 13 (6.1) | 159 (74.7) | |||
unknown | 0 | 2 | |||
Ki67 | positive | 9 (4.3) | 19 (9.1) | 0.0004 | 6.63 |
negative | 12 (5.8) | 168 (80.8) | |||
unknown | 1 | 5 |
Relationship of PLK1 expression to TP53status in breast cancer patients
Site of Mutation | Effect | PLK Neg (0-3) | PLK1 Pos (4-18) |
---|---|---|---|
Exon 4
| Deletion | 1 | 0 |
Exon 5
| Missense | 11 | 6 |
Nonsense | 1 | 0 | |
Exon 6
| Missense | 5 | 0 |
Nonsense | 2 | 1 | |
Exon 7
| Deletion | 7 | 2 |
Exon 8
| Missense | 9 | 2 |
Exon 9
| Nonsense | 1 | 0 |
Exon 10
| Deletion | 1 | 0 |
Missense | 2 | 0 | |
Intron 5
| Frame Shift | 2 | 0 |
Intron 6
| Frame Shift | 1 | 1 |
Intron 9
| Frame Shift | 1 | 0 |
*Exon 5 and 6
| Missense, Silent | 1 | 0 |
*Exon 7, 8 and 9
| Missense, Missense, Silent | 1 | 0 |
46
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12
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