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Current Hematologic Malignancy Reports

Erschienen in:

02.02.2018 | T-Cell and Other Lymphoproliferative Malignancies (J Zain, Section Editor)

Immunologic Milieu of Mature T-Cell and NK-Cell Lymphomas—Implications for Therapy

verfasst von: Eric Tse, Yok-Lam Kwong

Erschienen in: Current Hematologic Malignancy Reports | Ausgabe 1/2018

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Abstract

Purpose of the Review

T-cells and natural killer (NK) cells share the same ontogeny, and lymphomas derived from them are clinically diverse, occurring in nodal and extranodal sites. In addition to inherent properties of these lymphomas, their microenvironment also impacts on pathogenesis and response to therapy. An understanding of the milieu of T-cell and NK cell lymphomas has important implications on treatment.

Recent Findings

Components of the microenvironment include tumour-associated macrophages (TAM), non-neoplastic T-cells and B-cells, eosinophils, dendritic cells, endothelial cells and blood vessels. TAM typically undergoes M2 polarization, promoting angiogenesis and inhibiting anti-tumour cellular immunity. In lymphomas of follicular helper T-cell derivation, increased B-cell proliferation occurs, which may in turn enhance neoplastic T-cell growth. The expression of immune checkpoint ligands on TAM, dendritic cells or lymphoma cells induces an immunosuppressive environment conducive to neoplastic proliferation. Strategies against this complex cellular and immunologic microenvironment have shown promises. These include the use of signal transduction inhibitors, monoclonal antibodies against chemokines or non-neoplastic microenvironmental cells, immunomodulatory drugs and immune checkpoint blockade. As T-cell and NK cell lymphomas are highly heterogeneous, clinical trials to demonstrate efficacy of a given therapeutic approach requires careful design aiming at enriching patient populations who will best respond.

Summary

Targeting of the immunologic milieu in T-cell and NK-cell lymphomas offers exciting challenges and opportunities.

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Titel: Immunologic Milieu of Mature T-Cell and NK-Cell Lymphomas—Implications for Therapy
verfasst von: Eric Tse
Yok-Lam Kwong
Publikationsdatum: 02.02.2018
Verlag: Springer US
Erschienen in: Current Hematologic Malignancy Reports / Ausgabe 1/2018
Print ISSN: 1558-8211
Elektronische ISSN: 1558-822X
DOI: https://doi.org/10.1007/s11899-018-0437-y

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Springer Medizin

Immunologic Milieu of Mature T-Cell and NK-Cell Lymphomas—Implications for Therapy

Abstract

Purpose of the Review

Recent Findings

Summary

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Stereotaktische Radiatio schlägt konventionelle Bestrahlung

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Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Abstract

Purpose of the Review

Recent Findings

Summary

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