Immunologische Mechanismen der allergenspezifischen Immuntherapie

Zurück zum Zitat Aalberse RC, Stapel SO, Schuurman J et al (2009) Immunoglobulin G4: an odd antibody. Clin Exp Allergy 39:469–477CrossRefPubMed Aalberse RC, Stapel SO, Schuurman J et al (2009) Immunoglobulin G4: an odd antibody. Clin Exp Allergy 39:469–477CrossRefPubMed

Zurück zum Zitat Akdis CA, Akdis M (2009) Mechanisms and treatment of allergic disease in the big picture of regulatory T cells. J Allergy Clin Immunol 123:735–746CrossRefPubMed Akdis CA, Akdis M (2009) Mechanisms and treatment of allergic disease in the big picture of regulatory T cells. J Allergy Clin Immunol 123:735–746CrossRefPubMed

Zurück zum Zitat Akdis CA, Akdis M (2011) Mechanisms of allergen-specific immunotherapy. J Allergy Clin Immunol 127:18–27CrossRefPubMed Akdis CA, Akdis M (2011) Mechanisms of allergen-specific immunotherapy. J Allergy Clin Immunol 127:18–27CrossRefPubMed

Zurück zum Zitat Akdis CA, Akdis M (2015) Mechanisms of allergen-specific immunotherapy and immune tolerance to allergens. World Allergy Organ J 8:17CrossRefPubMedPubMedCentral Akdis CA, Akdis M (2015) Mechanisms of allergen-specific immunotherapy and immune tolerance to allergens. World Allergy Organ J 8:17CrossRefPubMedPubMedCentral

Zurück zum Zitat Allam JP, Bieber T, Novak N (2009) Dendritic cells as potential targets for mucosal immunotherapy. Curr Opin Allergy Clin Immunol. doi:10.1097/aci.0b013e32833239a9 PubMed Allam JP, Bieber T, Novak N (2009) Dendritic cells as potential targets for mucosal immunotherapy. Curr Opin Allergy Clin Immunol. doi:10.​1097/​aci.​0b013e32833239a9​ PubMed

Zurück zum Zitat Allam JP, Wurtzen PA, Reinartz M et al (2010) Phl p 5 resorption in human oral mucosa leads to dose-dependent and time-dependent allergen binding by oral mucosal Langerhans cells, attenuates their maturation, and enhances their migratory and TGF-beta 1 and IL-10-producing properties. J Allergy Clin Immunol 126(3):638–645.e1CrossRefPubMed Allam JP, Wurtzen PA, Reinartz M et al (2010) Phl p 5 resorption in human oral mucosa leads to dose-dependent and time-dependent allergen binding by oral mucosal Langerhans cells, attenuates their maturation, and enhances their migratory and TGF-beta 1 and IL-10-producing properties. J Allergy Clin Immunol 126(3):638–645.e1CrossRefPubMed

Zurück zum Zitat Bohm L, Maxeiner J, Meyer-Martin H et al (2015) IL-10 and regulatory T cells cooperate in allergen-specific immunotherapy to ameliorate allergic asthma. J Immunol 194:887–897CrossRefPubMed Bohm L, Maxeiner J, Meyer-Martin H et al (2015) IL-10 and regulatory T cells cooperate in allergen-specific immunotherapy to ameliorate allergic asthma. J Immunol 194:887–897CrossRefPubMed

Zurück zum Zitat Burks AW, Calderon MA, Casale T et al (2013) Update on allergy immunotherapy: American Academy of Allergy, Asthma & Immunology/European Academy of Allergy and Clinical Immunology/PRACTALL consensus report. J Allergy Clin Immunol 131:1288–1296.e3CrossRefPubMed Burks AW, Calderon MA, Casale T et al (2013) Update on allergy immunotherapy: American Academy of Allergy, Asthma & Immunology/European Academy of Allergy and Clinical Immunology/PRACTALL consensus report. J Allergy Clin Immunol 131:1288–1296.e3CrossRefPubMed

Zurück zum Zitat Bussmann C, Xia J, Allam JP et al (2010) Early markers for protective mechanisms during rush venom immunotherapy. Allergy. doi:10.1111/j.1398-9995.2010.02430.x PubMed Bussmann C, Xia J, Allam JP et al (2010) Early markers for protective mechanisms during rush venom immunotherapy. Allergy. doi:10.​1111/​j.​1398-9995.​2010.​02430.​x PubMed

Zurück zum Zitat Calderon MA, Casale T, Cox L et al (2013) Allergen immunotherapy: a new semantic framework from the European Academy of Allergy and Clinical Immunology/American Academy of Allergy, Asthma and Immunology/PRACTALL consensus report. Allergy 68:825–828CrossRefPubMed Calderon MA, Casale T, Cox L et al (2013) Allergen immunotherapy: a new semantic framework from the European Academy of Allergy and Clinical Immunology/American Academy of Allergy, Asthma and Immunology/PRACTALL consensus report. Allergy 68:825–828CrossRefPubMed

Zurück zum Zitat Canonica GW, Passalacqua G (2003) Noninjection routes for immunotherapy. J Allergy Clin Immunol 111:437–449CrossRefPubMed Canonica GW, Passalacqua G (2003) Noninjection routes for immunotherapy. J Allergy Clin Immunol 111:437–449CrossRefPubMed

Zurück zum Zitat Durham SR (1998) The inflammatory nature of allergic disease. Clin Exp Allergy 28(Suppl 6):20–24CrossRefPubMed Durham SR (1998) The inflammatory nature of allergic disease. Clin Exp Allergy 28(Suppl 6):20–24CrossRefPubMed

Zurück zum Zitat Durham SR, Emminger W, Kapp A et al (2012) SQ-standardized sublingual grass immunotherapy: confirmation of disease modification 2 years after 3 years of treatment in a randomized trial. J Allergy Clin Immunol 129:717–725.e5CrossRefPubMed Durham SR, Emminger W, Kapp A et al (2012) SQ-standardized sublingual grass immunotherapy: confirmation of disease modification 2 years after 3 years of treatment in a randomized trial. J Allergy Clin Immunol 129:717–725.e5CrossRefPubMed

Zurück zum Zitat Gomez E, Fernandez TD, Dona I et al (2015) Initial immunological changes as predictors for house dust mite immunotherapy response. Clin Exp Allergy 45:1542–1553CrossRefPubMed Gomez E, Fernandez TD, Dona I et al (2015) Initial immunological changes as predictors for house dust mite immunotherapy response. Clin Exp Allergy 45:1542–1553CrossRefPubMed

Zurück zum Zitat Jutel M, Jaeger L, Suck R et al (2005) Allergen-specific immunotherapy with recombinant grass pollen allergens. J Allergy Clin Immunol 116:608–613CrossRefPubMed Jutel M, Jaeger L, Suck R et al (2005) Allergen-specific immunotherapy with recombinant grass pollen allergens. J Allergy Clin Immunol 116:608–613CrossRefPubMed

Zurück zum Zitat Kappen JH, Durham SR, Veen HI et al (2017) Applications and mechanisms of immunotherapy in allergic rhinitis and asthma. Ther Adv Respir Dis 11:73–86CrossRefPubMed Kappen JH, Durham SR, Veen HI et al (2017) Applications and mechanisms of immunotherapy in allergic rhinitis and asthma. Ther Adv Respir Dis 11:73–86CrossRefPubMed

Zurück zum Zitat Pfaar O, Bachert C, Bufe A et al (2014) Guideline on allergen-specific immunotherapy in IgE-mediated allergic diseases: S2k Guideline of the German Society for Allergology and Clinical Immunology (DGAKI), the Society for Pediatric Allergy and Environmental Medicine (GPA), the Medical Association of German Allergologists (AeDA), the Austrian Society for Allergy and Immunology (OGAI), the Swiss Society for Allergy and Immunology (SGAI), the German Society of Dermatology (DDG), the German Society of Oto-Rhino-Laryngology, Head and Neck Surgery (DGHNO-KHC), the German Society of Pediatrics and Adolescent Medicine (DGKJ), the Society for Pediatric Pneumology (GPP), the German Respiratory Society (DGP), the German Association of ENT Surgeons (BV-HNO), the Professional Federation of Paediatricians and Youth Doctors (BVKJ), the Federal Association of Pulmonologists (BDP) and the German Dermatologists Association (BVDD). Allergo J Int 23:282–319CrossRefPubMedPubMedCentral Pfaar O, Bachert C, Bufe A et al (2014) Guideline on allergen-specific immunotherapy in IgE-mediated allergic diseases: S2k Guideline of the German Society for Allergology and Clinical Immunology (DGAKI), the Society for Pediatric Allergy and Environmental Medicine (GPA), the Medical Association of German Allergologists (AeDA), the Austrian Society for Allergy and Immunology (OGAI), the Swiss Society for Allergy and Immunology (SGAI), the German Society of Dermatology (DDG), the German Society of Oto-Rhino-Laryngology, Head and Neck Surgery (DGHNO-KHC), the German Society of Pediatrics and Adolescent Medicine (DGKJ), the Society for Pediatric Pneumology (GPP), the German Respiratory Society (DGP), the German Association of ENT Surgeons (BV-HNO), the Professional Federation of Paediatricians and Youth Doctors (BVKJ), the Federal Association of Pulmonologists (BDP) and the German Dermatologists Association (BVDD). Allergo J Int 23:282–319CrossRefPubMedPubMedCentral

Zurück zum Zitat Pfaar O, Demoly P, Gerth Van Wijk R et al (2014) Recommendations for the standardization of clinical outcomes used in allergen immunotherapy trials for allergic rhinoconjunctivitis: an EAACI Position Paper. Allergy 69:854–867CrossRefPubMed Pfaar O, Demoly P, Gerth Van Wijk R et al (2014) Recommendations for the standardization of clinical outcomes used in allergen immunotherapy trials for allergic rhinoconjunctivitis: an EAACI Position Paper. Allergy 69:854–867CrossRefPubMed

Zurück zum Zitat Reisinger J, Horak F, Pauli G et al (2005) Allergen-specific nasal IgG antibodies induced by vaccination with genetically modified allergens are associated with reduced nasal allergen sensitivity. J Allergy Clin Immunol 116:347–354CrossRefPubMed Reisinger J, Horak F, Pauli G et al (2005) Allergen-specific nasal IgG antibodies induced by vaccination with genetically modified allergens are associated with reduced nasal allergen sensitivity. J Allergy Clin Immunol 116:347–354CrossRefPubMed

Zurück zum Zitat Ring J, Gutermuth J (2011) 100 years of hyposensitization: history of allergen-specific immunotherapy (ASIT). Allergy 66:713–724CrossRefPubMed Ring J, Gutermuth J (2011) 100 years of hyposensitization: history of allergen-specific immunotherapy (ASIT). Allergy 66:713–724CrossRefPubMed

Zurück zum Zitat Schmid JM, Wurtzen PA, Dahl R et al (2014) Early improvement in basophil sensitivity predicts symptom relief with grass pollen immunotherapy. J Allergy Clin Immunol 134:741–744.e5CrossRefPubMed Schmid JM, Wurtzen PA, Dahl R et al (2014) Early improvement in basophil sensitivity predicts symptom relief with grass pollen immunotherapy. J Allergy Clin Immunol 134:741–744.e5CrossRefPubMed

Zurück zum Zitat Wachholz PA, Nouri-Aria KT, Wilson DR et al (2002) Grass pollen immunotherapy for hayfever is associated with increases in local nasal but not peripheral Th1:Th2 cytokine ratios. Immunology 105:56–62CrossRefPubMedPubMedCentral Wachholz PA, Nouri-Aria KT, Wilson DR et al (2002) Grass pollen immunotherapy for hayfever is associated with increases in local nasal but not peripheral Th1:Th2 cytokine ratios. Immunology 105:56–62CrossRefPubMedPubMedCentral

Zurück zum Zitat Wambre E (2015) Effect of allergen-specific immunotherapy on CD4+ T cells. Curr Opin Allergy Clin Immunol 15:581–587CrossRefPubMedPubMedCentral Wambre E (2015) Effect of allergen-specific immunotherapy on CD4+ T cells. Curr Opin Allergy Clin Immunol 15:581–587CrossRefPubMedPubMedCentral

Zurück zum Zitat Wilson DR, Lima MT, Durham SR (2005) Sublingual immunotherapy for allergic rhinitis: systematic review and meta-analysis. Allergy 60:4–12CrossRefPubMed Wilson DR, Lima MT, Durham SR (2005) Sublingual immunotherapy for allergic rhinitis: systematic review and meta-analysis. Allergy 60:4–12CrossRefPubMed

Zurück zum Zitat Zimmer A, Bouley J, Le Mignon M et al (2012) A regulatory dendritic cell signature correlates with the clinical efficacy of allergen-specific sublingual immunotherapy. J Allergy Clin Immunol 129:1020–1030CrossRefPubMed Zimmer A, Bouley J, Le Mignon M et al (2012) A regulatory dendritic cell signature correlates with the clinical efficacy of allergen-specific sublingual immunotherapy. J Allergy Clin Immunol 129:1020–1030CrossRefPubMed