Introduction
HLA-G molecules
HLA-G mediates immune regulation
Direct regulations of HLA-G on immune cells
Effect of HLA-G on T cells
Effect of HLA-G on NK cells
Effect of HLA-G on APCs
Effect of HLA-G on B cells
Indirect regulations of HLA-G on immune system
Upregulation of inhibitory receptor expression induced by HLA-G
HLA-G induces the production of regulatory T cells
The action mechanism of HLA-G through trogocytosis
HLA-G mediates transplantation tolerance
The role of HLA-G in graft-versus-host disease
Correlation between HLA-G and GVHD
Study | N | Role in GVHD |
---|---|---|
Le Maux et al. [8] | 20 | Soluble HLA-G level was significantly higher before transplantation and post-allograft period of without aGVHD patients compared with aGVHD patients. sHLA-G molecules could be involved in aGVHD prevention |
Nomura et al. [12] | 135 | Elevated HLA-G/sHLA-G participates in the pathophysiology and prevention of aGVHD |
Liu et al. [9] | 106 | The increased levels of sHLA-G5 after transplantation were negatively correlated with the severity of aGVHD. sHLA-G5 might predict the occurrence and severity of aGVHD |
Biedron et al. [10] | 32 | Soluble HLA-G level was related to intensity of GVHD and may play the role of a prognostic factor for the development of GVHD and the clinical course of this reaction |
Kordelas et al. [11] | 32 | Elevated sHLA-G levels were correlated with less severe acute and chronic GvHD and with a superior overall survival |
Waterhouse et al. [52] | 59 | Soluble HLA-G concentration had no correlation between post-transplantation complications such as aGVHD, cGVHD, relapse, or death |
Correlation between 14-bp polymorphism and GVHD
Study | N | Role in GVHD |
---|---|---|
Boukouaci et al. [56] | 157 | The HLA-G low expressor 14bp ins allele constituted a risk factor for the incidence of severe aGVHD |
La Nasa et al. [57] | 53 | Homozygous for the 14-bp deletion had a higher risk of developing aGVHD than homozygous for the 14-bp insertion. The 14-bp polymorphism could be an important predictive factor for aGVHD |
Sizzano et al. [58] | 147 | The 14-bp ins had no association between graft rejection, TFS, OS, or PMC |
Waterhouse et al. [52] | 59 | HLA-G 14-bp polymorphism had no correlation between post-transplantation complications such as aGVHD, cGVHD, relapse, or death |
Chiusolo et al. [59] | 47 | HLA-G 14-bp polymorphism had no correlation between the risks of aGVHD occurrence. The 14-bp ins/14-bp ins genotype was characterized by a lower OS and DFS |