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Erschienen in:

01.11.2019 | Focussed Research Review

Immunomodulation by Schwann cells in disease

verfasst von: Sophia H. Zhang, Galina V. Shurin, Hasan Khosravi, Rashek Kazi, Oleg Kruglov, Michael R. Shurin, Yuri L. Bunimovich

Erschienen in: Cancer Immunology, Immunotherapy | Ausgabe 2/2020

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Abstract

Schwann cells are the principal glial cells of the peripheral nervous system which maintain neuronal homeostasis. Schwann cells support peripheral nerve functions and play a critical role in many pathological processes including injury-induced nerve repair, neurodegenerative diseases, infections, neuropathic pain and cancer. Schwann cells are implicated in a wide range of diseases due, in part, to their ability to interact and modulate immune cells. We discuss the accumulating examples of how Schwann cell regulation of the immune system initiates and facilitates the progression of various diseases. Furthermore, we highlight how Schwann cells may orchestrate an immunosuppressive tumor microenvironment by polarizing and modulating the activity of the dendritic cells.

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Titel: Immunomodulation by Schwann cells in disease
verfasst von: Sophia H. Zhang
Galina V. Shurin
Hasan Khosravi
Rashek Kazi
Oleg Kruglov
Michael R. Shurin
Yuri L. Bunimovich
Publikationsdatum: 01.11.2019
Verlag: Springer Berlin Heidelberg
Erschienen in: Cancer Immunology, Immunotherapy / Ausgabe 2/2020
Print ISSN: 0340-7004
Elektronische ISSN: 1432-0851
DOI: https://doi.org/10.1007/s00262-019-02424-7

Neu im Fachgebiet Onkologie

25.04.2024 | Nierenkarzinom | Nachrichten

Springer Medizin

Immunomodulation by Schwann cells in disease

Abstract

Neu im Fachgebiet Onkologie

Adjuvante Immuntherapie verlängert Leben bei RCC

Alectinib verbessert krankheitsfreies Überleben bei ALK-positivem NSCLC

Bei Senioren mit Prostatakarzinom auf Anämie achten!

ICI-Therapie in der Schwangerschaft wird gut toleriert

Update Onkologie

Springer Medizin

Abstract

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