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Erschienen in: HNO 3/2019

11.01.2019 | Kopf-Hals-Tumoren | CME

Immunonkologie von Kopf-Hals-Tumoren

verfasst von: Univ.-Prof. Dr. Stefan Kasper, Timon Hussain, Isabel Virchow, Martin Stuschke, Stephan Lang

Erschienen in: HNO | Ausgabe 3/2019

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Zusammenfassung

Die Behandlung von Patienten mit Plattenepithelkarzinomen des Kopf-Hals-Bereichs ist multimodal unter Einschluss modernster operativer, strahlentherapeutischer sowie medikamentöser Verfahren. Dennoch bleibt die Prognose über alle Stadien unbefriedigend. Bei einem Rezidiv oder einer Metastasierung nach definitiver Therapie besteht die Indikation zur systemischen palliativen Therapie, wobei sich neben der klassischen platinbasierten Chemotherapie und Cetuximab, einem Antikörper gegen den epidermalen Wachstumsfaktorrezeptor („epidermal growth factor receptor“, EGFR), in den letzten Jahren die immunonkologische (IO-)Therapie erfolgreich etabliert hat. Für die Zulassung von „Checkpointinhibitoren“ in der palliativen Situation nach Platinversagen relevante Studienergebnisse sowie derzeit laufende Studien zu deren Stellenwert in Erstlinientherapie, Kombination mit definitiver oder adjuvanter Bestrahlung, präoperativ beim resektablen Kopf-Hals-Tumor sowie in IO-Kombinationstherapie werden erörtert.
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Metadaten
Titel
Immunonkologie von Kopf-Hals-Tumoren
verfasst von
Univ.-Prof. Dr. Stefan Kasper
Timon Hussain
Isabel Virchow
Martin Stuschke
Stephan Lang
Publikationsdatum
11.01.2019
Verlag
Springer Medizin
Erschienen in
HNO / Ausgabe 3/2019
Print ISSN: 0017-6192
Elektronische ISSN: 1433-0458
DOI
https://doi.org/10.1007/s00106-018-0602-6

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