The online version of this article (doi:10.1186/s12893-015-0094-1) contains supplementary material, which is available to authorized users.
Wei Wang and Lei Liu contributed equally to this work.
The authors declare that they have no competing interests.
WW, LL, and ZWW were responsible for data collection and analysis, experiment job, interpretation of the results, and writing the manuscript. MW, QH, ZAC, YXZ and QW, were responsible for conducting the data analysis, reviewing and follow-up. WW and MXS were responsible for experimental design, analysis, and interpretation. All authors have read and approved the final manuscript.
ABO blood type is an established prognostic factor in several malignancies, but its role in esophageal cancer (EC) is largely unknown. The aim of this study is to determine whether ABO blood group is associated with survival after esophagectomy for EC.
A total of 406 patients who underwent surgery for EC were enrolled. The associations of ABO blood group with clinical and pathological variables were assessed using chi-square test. Associations of ABO blood group with the survival were estimated using univariable and multivariable Cox proportional hazards regression models.
The ABO blood group proportionally associated with the grade of EC tumor (P = 0.049). The ABO blood group status did not correlate with disease-free survival (DFS) in univariable analysis or multivariable analysis (P > 0.05). And there was no significant relationship between the ABO blood group and overall survival (OS) in univariable analysis or multivariable analysis (P > 0.05).
Our results suggested that no association between ABO blood group and the survival was observed in patients undergoing surgery for EC.
Additional file 1: Table S1. The clinical and pathological variables in follow-up and loss to follow-up patients with EC. (DOC 53 kb)12893_2015_94_MOESM1_ESM.doc
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- Impact of ABO blood group on the prognosis of patients undergoing surgery for esophageal cancer
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