The online version of this article (doi:10.1186/1471-2261-14-79) contains supplementary material, which is available to authorized users.
The authors declare that they have no competing interests.
RT undertook the data analyses, interpretation of the data, drafting of the manuscript and giving final approval of the version to be published. AV participated in the study design, interpretation of the analyses, revising the manuscript and giving final approval of the version to be published. LH assisted with the data analyses, revising the manuscript and giving final approval of the version to be published. OR assisted with interpretation of the data, drafting of the manuscript and giving final approval of the version to be published. OU assisted with interpretation of the data, drafting of the manuscript and giving final approval of the version to be published. TD participated in the study design, interpretation of the analyses, revising the manuscript and giving final approval of the version to be published. CM assisted with the interpretation of the data, drafting of the manuscript and giving final approval of the version to be published. All authors read and approved the final manuscript.
We have examined the association between adiposity and cardiac structure in adulthood, using a life course approach that takes account of the contribution of adiposity in both childhood and adulthood.
The Childhood Determinants of Adult Health study (CDAH) is a follow-up study of 8,498 children who participated in the 1985 Australian Schools Health and Fitness Survey (ASHFS). The CDAH follow-up study included 2,410 participants who attended a clinic examination. Of these, 181 underwent cardiac imaging and provided complete data. The measures were taken once when the children were aged 9 to 15 years, and once in adult life, aged 26 to 36 years.
There was a positive association between adult left ventricular mass (LVM) and childhood body mass index (BMI) in males (regression coefficient (β) 0.41; 95% confidence interval (CI): 0.14 to 0.67; p = 0.003), and females (β = 0.53; 95% CI: 0.34 to 0.72; p < 0.001), and with change in BMI from childhood to adulthood (males: β = 0.27; 95% CI: 0.04 to 0.51; p < 0.001, females: β = 0.39; 95% CI: 0.20 to 0.58; p < 0.001), after adjustment for confounding factors (age, fitness, triglyceride levels and total cholesterol in adulthood). After further adjustment for known potential mediating factors (systolic BP and fasting plasma glucose in adulthood) the relationship of LVM with childhood BMI (males: β = 0.45; 95% CI: 0.19 to 0.71; p = 0.001, females: β = 0.49; 95% CI: 0.29 to 0.68; p < 0.001) and change in BMI (males: β = 0.26; 95% CI: 0.04 to 0.49; p = 0.02, females: β = 0.40; 95% CI: 0.20 to 0.59; p < 0.001) did not change markedly.
Adiposity and increased adiposity from childhood to adulthood appear to have a detrimental effect on cardiac structure.
Gardin JM, McClelland R, Kitzman D, Lima JA, Bommer W, Klopfenstein HS, Wong ND, Smith VE, Gottdiener J: M-mode echocardiographic predictors of six- to seven-year incidence of coronary heart disease, stroke, congestive heart failure, and mortality in an elderly cohort (the cardiovascular health study). Am J Cardiol. 2001, 87: 1051-1057. CrossRefPubMed
Venn AJ, Thomson RJ, Schmidt MD, Cleland VJ, Curry BA, Gennat HC, Dwyer T: Overweight and obesity from childhood to adulthood: A follow-up of participants in the 1985 australian schools health and fitness survey. Med J Aust. 2007, 186: 458-460. PubMed
Magnussen CG, Raitakari OT, Thomson R, Juonala M, Patel DA, Viikari JS, Marniemi J, Srinivasan SR, Berenson GS, Dwyer T, Venn A: Utility of currently recommended pediatric dyslipidemia classifications in predicting dyslipidemia in adulthood: Evidence from the childhood determinants of adult health (cdah) study, cardiovascular risk in young finns study, and bogalusa heart study. Circulation. 2008, 117: 32-42. CrossRefPubMed
Dwyer T, Gibbons LE: The australian schools health and fitness survey. Physical fitness related to blood pressure but not lipoproteins Circulation. 1994, 89: 1539-1544.
Dwyer T, Magnussen CG, Schmidt MD, Ukoumunne OC, Ponsonby AL, Raitakari OT, Zimmet PZ, Blair SN, Thomson R, Cleland VJ, Venn A: Decline in physical fitness from childhood to adulthood associated with increased obesity and insulin resistance in adults. Diabetes Care. 2009, 32: 683-687. CrossRefPubMed
Siri W: Gross composition of the body. Advances in biological and medical physics. Edited by: Lawrence JH TC. 1956, New York: Accademic Press
Sjostrand T: Changes in the respiratory organs of workmen at an ore smelting works. Acta Med Scand. 1947, 196 (Suppl): 687-699.
Wahlund H: Determination of the physical working capacity. Acta Med Scand. 1948, 215 (Suppl): 1-78.
Lipid research clinics program: Manual of laboratory operations: Lipid and lipoprotein analysis. 1974, Bethesda, MD: National Institutes of Health: US Dept of Health, Education and Welfare publication NIH, 75-628.
Friedewald WT, Levy RI, Fredrickson DS: Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem. 1972, 18: 499-502. PubMed
Coats AJ, Shewan LG: Statement on authorship and publishing ethics in the international journal of cardiology. Int J Cardiol. 2011, 153: 239-240. PubMed
Parks RJ, Howlett SE: Sex differences in mechanisms of cardiac excitation-contraction coupling. Arch Eur J Physiol. 2013, 465: 747-763. CrossRef
Schunkert H: Obesity and target organ damage: The heart. Int J Obesity Relate Metabolic Disorders J Int Assoc Study Obesity. 2002, 26 (Suppl 4): S15-S20. CrossRef
- Impact of adiposity on cardiac structure in adult life: the childhood determinants of adult health (CDAH) study
Robyn J Tapp
Quan L Huynh
Olli T Raitakari
Obioha C Ukoumunne
Costan G Magnussen
- BioMed Central
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