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01.12.2014 | Research article | Ausgabe 1/2014 Open Access

BMC Cardiovascular Disorders 1/2014

Impact of adiposity on cardiac structure in adult life: the childhood determinants of adult health (CDAH) study

Zeitschrift:
BMC Cardiovascular Disorders > Ausgabe 1/2014
Autoren:
Robyn J Tapp, Alison Venn, Quan L Huynh, Olli T Raitakari, Obioha C Ukoumunne, Terence Dwyer, Costan G Magnussen
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​1471-2261-14-79) contains supplementary material, which is available to authorized users.

Competing interests

The authors declare that they have no competing interests.

Authors’ contributions

RT undertook the data analyses, interpretation of the data, drafting of the manuscript and giving final approval of the version to be published. AV participated in the study design, interpretation of the analyses, revising the manuscript and giving final approval of the version to be published. LH assisted with the data analyses, revising the manuscript and giving final approval of the version to be published. OR assisted with interpretation of the data, drafting of the manuscript and giving final approval of the version to be published. OU assisted with interpretation of the data, drafting of the manuscript and giving final approval of the version to be published. TD participated in the study design, interpretation of the analyses, revising the manuscript and giving final approval of the version to be published. CM assisted with the interpretation of the data, drafting of the manuscript and giving final approval of the version to be published. All authors read and approved the final manuscript.

Abstract

Background

We have examined the association between adiposity and cardiac structure in adulthood, using a life course approach that takes account of the contribution of adiposity in both childhood and adulthood.

Methods

The Childhood Determinants of Adult Health study (CDAH) is a follow-up study of 8,498 children who participated in the 1985 Australian Schools Health and Fitness Survey (ASHFS). The CDAH follow-up study included 2,410 participants who attended a clinic examination. Of these, 181 underwent cardiac imaging and provided complete data. The measures were taken once when the children were aged 9 to 15 years, and once in adult life, aged 26 to 36 years.

Results

There was a positive association between adult left ventricular mass (LVM) and childhood body mass index (BMI) in males (regression coefficient (β) 0.41; 95% confidence interval (CI): 0.14 to 0.67; p = 0.003), and females (β = 0.53; 95% CI: 0.34 to 0.72; p < 0.001), and with change in BMI from childhood to adulthood (males: β = 0.27; 95% CI: 0.04 to 0.51; p < 0.001, females: β = 0.39; 95% CI: 0.20 to 0.58; p < 0.001), after adjustment for confounding factors (age, fitness, triglyceride levels and total cholesterol in adulthood). After further adjustment for known potential mediating factors (systolic BP and fasting plasma glucose in adulthood) the relationship of LVM with childhood BMI (males: β = 0.45; 95% CI: 0.19 to 0.71; p = 0.001, females: β = 0.49; 95% CI: 0.29 to 0.68; p < 0.001) and change in BMI (males: β = 0.26; 95% CI: 0.04 to 0.49; p = 0.02, females: β = 0.40; 95% CI: 0.20 to 0.59; p < 0.001) did not change markedly.

Conclusions

Adiposity and increased adiposity from childhood to adulthood appear to have a detrimental effect on cardiac structure.
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