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19.04.2019 | Review | Ausgabe 3-4/2019

Medical Microbiology and Immunology 3-4/2019

Impact of CMV upon immune aging: facts and fiction

Zeitschrift:
Medical Microbiology and Immunology > Ausgabe 3-4/2019
Autoren:
Mladen Jergović, Nico A. Contreras, Janko Nikolich-Žugich
Wichtige Hinweise
Edited by Matthias J. Reddehase.
This article is part of the Special Issue on Immunological Imprinting during Chronic Viral Infection.

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Abstract

Aging is accompanied by significant defects in immunity and compromised responses to new, previously unencountered microbial pathogens. Most humans carry several persistent or latent viruses as they age, interacting with the host immune systems for years. In that context maybe the most studied persistent virus is Cytomegalovirus, infamous for its ability to recruit very large T cell responses which increase with age and to simultaneously evade elimination by the immune system. Here we will address how lifelong CMV infection and the immunological burden of its control might affect immune reactivity and health of the host over time.

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