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27.07.2023 | Review

Impact of curcumin on p38 MAPK: therapeutic implications

verfasst von: Hedieh Sadat Shamsnia, Mahtab Roustaei, Danial Ahmadvand, Alexandra E. Butler, Dorsa Amirlou, Sanam Soltani, Saeideh Momtaz, Tannaz Jamialahmadi, Amir Hossein Abdolghaffari, Amirhossein Sahebkar

Erschienen in: Inflammopharmacology | Ausgabe 5/2023

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Abstract

Curcumin (diferuloylmethane) is a herbal remedy which possesses numerous biological attributes including anti-inflammatory, anti-oxidant and anti-cancer properties. Curcumin has been shown to impact a number of signaling pathways including nuclear factor kappa B (NF-KB), reactive oxygen species (ROS), Wingless/Integrated (Wnt), Janus kinase-signal transducer and activator of mitogen-activated protein kinase (MAPK) and transcription (JAK/STAT). P38 belongs to the MAPKs, is known as a stress-activated MAPK and is involved in diverse biological responses. P38 is activated in various signaling cascades. P38 plays a role in inflammation, cell differentiation, proliferation, motility and survival. This cascade can serve as a therapeutic target in many disorders. Extensive evidence confirms that curcumin impacts the P38 MAPK signaling pathway, through which it exerts anti-inflammatory, neuroprotective, and apoptotic effects. Hence, curcumin can positively affect inflammatory disorders and cancers, as well as to increase glucose uptake in cells. This review discusses the pharmacological and therapeutic effects of curcumin as effected through p38 MAPK.

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Titel: Impact of curcumin on p38 MAPK: therapeutic implications
verfasst von: Hedieh Sadat Shamsnia
Mahtab Roustaei
Danial Ahmadvand
Alexandra E. Butler
Dorsa Amirlou
Sanam Soltani
Saeideh Momtaz
Tannaz Jamialahmadi
Amir Hossein Abdolghaffari
Amirhossein Sahebkar
Publikationsdatum: 27.07.2023
Verlag: Springer International Publishing
Erschienen in: Inflammopharmacology / Ausgabe 5/2023
Print ISSN: 0925-4692
Elektronische ISSN: 1568-5608
DOI: https://doi.org/10.1007/s10787-023-01265-2

Live-Webinar "Schulterschmerz in der Praxis gezielt managen"

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Impact of curcumin on p38 MAPK: therapeutic implications

Abstract

Live-Webinar "Schulterschmerz in der Praxis gezielt managen"

Springer Medizin

Abstract

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