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Medical Microbiology and Immunology

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11.04.2019 | Review

Impact of cytomegalovirus load on host response to sepsis

verfasst von: Thomas Marandu, Michael Dombek, Charles H. Cook

Erschienen in: Medical Microbiology and Immunology | Ausgabe 3-4/2019

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Abstract

There is a decades old association between cytomegalovirus reactivation and sepsis in immune-competent hosts. Much has been learned about this relationship, which has been described as bidirectional, meaning that the virus incites and is incited by the host’s inflammatory response. More recent work has suggested that chronic viral infection leaves the host with exaggerated immunity to bacterial infections. In this review, the relationship between CMV and host responses to sepsis are reviewed, with particular attention to the impact that tissue viral load contributes to this phenomenon.

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Titel: Impact of cytomegalovirus load on host response to sepsis
verfasst von: Thomas Marandu
Michael Dombek
Charles H. Cook
Publikationsdatum: 11.04.2019
Verlag: Springer Berlin Heidelberg
Erschienen in: Medical Microbiology and Immunology / Ausgabe 3-4/2019
Print ISSN: 0300-8584
Elektronische ISSN: 1432-1831
DOI: https://doi.org/10.1007/s00430-019-00603-y

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