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16.05.2020 | Review Article

Impact of diabetes mellitus simulations on bone cell behavior through in vitro models

verfasst von: Yihan Li, Annie Shrestha, Hongmei Zhang, Lingjie Li, Dize Li, Tiwei Fu, Jinlin Song, Ping Ji, Yuanding Huang, Tao Chen

Erschienen in: Journal of Bone and Mineral Metabolism | Ausgabe 5/2020

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Abstract

Diabetes mellitus (DM) is related to impaired bone healing and an increased risk of bone fractures. While it is recognized that osteogenic differentiation and the function of osteoblasts are suppressed in DM, the influence of DM on osteoclasts is still unclear. Hyperglycemia and inflammatory environment are the hallmark of DM that causes dysregulation of various pro-inflammatory cytokines and alternated gene expression in periodontal ligament cells, osteoblasts, osteocytes, osteoclasts, and osteoclast precursors. A methodological review on conceptual and practical implications of in vitro study models is used for DM simulation on bone cells. Several major databases were screened to find literature related to the study objective. Published literature within last 20 years that used in vitro DM-simulated models to study how DM affects the cellular behavior of bone cells were selected for this review. Studies utilizing high glucose and serum acquired from diabetic animals are the mainly used methods to simulate the diabetic condition. The combination with various simulating factors such as lipopolysaccharide (LPS), hydrogen peroxide (H2O2), and advanced glycation end products (AGEs) have been reported in diabetic situations in vitro, as well. Through screening procedure, it was evident DM-simulated conditions exerted negative impact on bone-related cells. However, inconsistent results were found among different reported studies, which could be due to variation in culture conditions, concentrations of the stimulating factors and cell lineage, etc. This manuscript has concisely reviewed currently existing DM-simulated in vitro models and provides valuable insights of detailed components in simulating DM conditions in vitro. Studies using DM-simulated microenvironment revealed that in vitro simulation negatively impacted periodontal ligament cells, osteoblasts, osteocytes, osteoclasts, and osteoclast precursors. Contrarily, studies also indicated beneficial influence on bone-related cells when such conditions are reversed.
Literatur
1.
Zurück zum Zitat Lontchi-Yimagou E, Sobngwi E, Matsha TE, Kengne AP (2013) Diabetes mellitus and inflammation. Curr Diab Rep 13:435–444PubMedCrossRef Lontchi-Yimagou E, Sobngwi E, Matsha TE, Kengne AP (2013) Diabetes mellitus and inflammation. Curr Diab Rep 13:435–444PubMedCrossRef
3.
Zurück zum Zitat Wild S, Roglic G, Green A, Sicree R, King H (2004) Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care 27:1047–1053PubMedCrossRef Wild S, Roglic G, Green A, Sicree R, King H (2004) Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care 27:1047–1053PubMedCrossRef
4.
Zurück zum Zitat Kim JY, Lee SK, Jo KJ, Song DY, Lim DM, Park KY, Bonewald LF, Kim BJ (2013) Exendin-4 increases bone mineral density in type 2 diabetic OLETF rats potentially through the down-regulation of SOST/sclerostin in osteocytes. Life Sci 92:533–540CrossRef Kim JY, Lee SK, Jo KJ, Song DY, Lim DM, Park KY, Bonewald LF, Kim BJ (2013) Exendin-4 increases bone mineral density in type 2 diabetic OLETF rats potentially through the down-regulation of SOST/sclerostin in osteocytes. Life Sci 92:533–540CrossRef
5.
Zurück zum Zitat Hu Z, Ma C, Liang Y, Zou S, Liu X (2019) Osteoclasts in bone regeneration under type 2 diabetes mellitus. Acta Biomater 84:402–413PubMedCrossRef Hu Z, Ma C, Liang Y, Zou S, Liu X (2019) Osteoclasts in bone regeneration under type 2 diabetes mellitus. Acta Biomater 84:402–413PubMedCrossRef
6.
Zurück zum Zitat Loder RT (1988) The influence of diabetes mellitus on the healing of closed fractures. Clin Orthop Relat Res 210–216 Loder RT (1988) The influence of diabetes mellitus on the healing of closed fractures. Clin Orthop Relat Res 210–216
7.
Zurück zum Zitat Hu Z, Ma C, Rong X, Zou S, Liu X (2018) Immunomodulatory ECM-like microspheres for accelerated bone regeneration in diabetes mellitus. ACS Appl Mater Interfaces 10:2377–2390PubMedPubMedCentralCrossRef Hu Z, Ma C, Rong X, Zou S, Liu X (2018) Immunomodulatory ECM-like microspheres for accelerated bone regeneration in diabetes mellitus. ACS Appl Mater Interfaces 10:2377–2390PubMedPubMedCentralCrossRef
9.
Zurück zum Zitat Chapple IL, Genco R, Working group 2 of joint EFPAAPw (2013) Diabetes and periodontal diseases: consensus report of the Joint EFP/AAP Workshop on Periodontitis and systemic diseases. J Clin Periodontol 40(Suppl 14):106–112 Chapple IL, Genco R, Working group 2 of joint EFPAAPw (2013) Diabetes and periodontal diseases: consensus report of the Joint EFP/AAP Workshop on Periodontitis and systemic diseases. J Clin Periodontol 40(Suppl 14):106–112
10.
Zurück zum Zitat Lalla E, Papapanou PN (2011) Diabetes mellitus and periodontitis: a tale of two common interrelated diseases. Nat Rev Endocrinol 7:738–748PubMedCrossRef Lalla E, Papapanou PN (2011) Diabetes mellitus and periodontitis: a tale of two common interrelated diseases. Nat Rev Endocrinol 7:738–748PubMedCrossRef
11.
Zurück zum Zitat Furman BL (2015) Streptozotocin-induced diabetic models in mice and rats. Curr Protoc Pharmacol 70:1–20 Furman BL (2015) Streptozotocin-induced diabetic models in mice and rats. Curr Protoc Pharmacol 70:1–20
12.
Zurück zum Zitat Al-Awar A, Kupai K, Veszelka M, Szucs G, Attieh Z, Murlasits Z, Torok S, Posa A, Varga C (2016) Experimental diabetes mellitus in different animal models. J Diabetes Res 2016:9051426PubMedPubMedCentralCrossRef Al-Awar A, Kupai K, Veszelka M, Szucs G, Attieh Z, Murlasits Z, Torok S, Posa A, Varga C (2016) Experimental diabetes mellitus in different animal models. J Diabetes Res 2016:9051426PubMedPubMedCentralCrossRef
13.
Zurück zum Zitat Chatzigeorgiou A, Halapas A (2009) The use of animal models in the study of diabetes mellitus. In vivo (Athens, Greece) 23:245–258 Chatzigeorgiou A, Halapas A (2009) The use of animal models in the study of diabetes mellitus. In vivo (Athens, Greece) 23:245–258
14.
Zurück zum Zitat Jin Z, Wei W, Yang M, Du Y, Wan Y (2014) Mitochondrial complex I activity suppresses inflammation and enhances bone resorption by shifting macrophage-osteoclast polarization. Cell Metab 20:483–498PubMedPubMedCentralCrossRef Jin Z, Wei W, Yang M, Du Y, Wan Y (2014) Mitochondrial complex I activity suppresses inflammation and enhances bone resorption by shifting macrophage-osteoclast polarization. Cell Metab 20:483–498PubMedPubMedCentralCrossRef
15.
Zurück zum Zitat Kalaitzoglou E, Popescu I, Bunn RC, Fowlkes JL, Thrailkill KM (2016) Effects of type 1 diabetes on osteoblasts, osteocytes, and osteoclasts. Curr Osteoporos Rep 14:310–319PubMedPubMedCentralCrossRef Kalaitzoglou E, Popescu I, Bunn RC, Fowlkes JL, Thrailkill KM (2016) Effects of type 1 diabetes on osteoblasts, osteocytes, and osteoclasts. Curr Osteoporos Rep 14:310–319PubMedPubMedCentralCrossRef
16.
Zurück zum Zitat Rathinavelu S, Guidry-Elizondo C, Banu J (2018) Molecular modulation of osteoblasts and osteoclasts in type 2 diabetes. J Diabetes Res 2018:6354787PubMedPubMedCentralCrossRef Rathinavelu S, Guidry-Elizondo C, Banu J (2018) Molecular modulation of osteoblasts and osteoclasts in type 2 diabetes. J Diabetes Res 2018:6354787PubMedPubMedCentralCrossRef
17.
Zurück zum Zitat Garcia-Hernandez A, Arzate H, Gil-Chavarria I, Rojo R, Moreno-Fierros L (2012) High glucose concentrations alter the biomineralization process in human osteoblastic cells. Bone 50:276–288PubMedCrossRef Garcia-Hernandez A, Arzate H, Gil-Chavarria I, Rojo R, Moreno-Fierros L (2012) High glucose concentrations alter the biomineralization process in human osteoblastic cells. Bone 50:276–288PubMedCrossRef
18.
Zurück zum Zitat Dong K, Hao P, Xu S, Liu S, Zhou W, Yue X, Rausch-Fan X, Liu Z (2017) Alpha-lipoic acid alleviates high-glucose suppressed osteogenic differentiation of MC3T3-E1 cells via antioxidant effect and PI3K/Akt signaling pathway. Cell Physiol Biochem 42:1897–1906PubMedCrossRef Dong K, Hao P, Xu S, Liu S, Zhou W, Yue X, Rausch-Fan X, Liu Z (2017) Alpha-lipoic acid alleviates high-glucose suppressed osteogenic differentiation of MC3T3-E1 cells via antioxidant effect and PI3K/Akt signaling pathway. Cell Physiol Biochem 42:1897–1906PubMedCrossRef
19.
Zurück zum Zitat Wu M, Ai W, Chen L, Zhao S, Liu E (2016) Bradykinin receptors and EphB2/EphrinB2 pathway in response to high glucose-induced osteoblast dysfunction and hyperglycemia-induced bone deterioration in mice. Int J Mol Med 37:565–574PubMedPubMedCentralCrossRef Wu M, Ai W, Chen L, Zhao S, Liu E (2016) Bradykinin receptors and EphB2/EphrinB2 pathway in response to high glucose-induced osteoblast dysfunction and hyperglycemia-induced bone deterioration in mice. Int J Mol Med 37:565–574PubMedPubMedCentralCrossRef
20.
Zurück zum Zitat Kalyanaraman H, Schwaerzer G, Ramdani G, Castillo F, Scott BT, Dillmann W, Sah RL, Casteel DE, Pilz RB (2018) Protein kinase G activation reverses oxidative stress and restores osteoblast function and bone formation in male mice with type 1 diabetes. Diabetes 67:607–623PubMedPubMedCentralCrossRef Kalyanaraman H, Schwaerzer G, Ramdani G, Castillo F, Scott BT, Dillmann W, Sah RL, Casteel DE, Pilz RB (2018) Protein kinase G activation reverses oxidative stress and restores osteoblast function and bone formation in male mice with type 1 diabetes. Diabetes 67:607–623PubMedPubMedCentralCrossRef
21.
Zurück zum Zitat Xiong Y, Zhang Y, Guo Y, Yuan Y, Guo Q, Gong P, Wu Y (2017) 1alpha,25-dihydroxyvitamin D3 increases implant osseointegration in diabetic mice partly through FoxO1 inactivation in osteoblasts. Biochem Biophys Res Commun 494:626–633PubMedCrossRef Xiong Y, Zhang Y, Guo Y, Yuan Y, Guo Q, Gong P, Wu Y (2017) 1alpha,25-dihydroxyvitamin D3 increases implant osseointegration in diabetic mice partly through FoxO1 inactivation in osteoblasts. Biochem Biophys Res Commun 494:626–633PubMedCrossRef
22.
Zurück zum Zitat Bartell SM, Kim HN, Ambrogini E, Han L, Iyer S, Serra Ucer S, Rabinovitch P, Jilka RL, Weinstein RS, Zhao H, O'Brien CA, Manolagas SC, Almeida M (2014) FoxO proteins restrain osteoclastogenesis and bone resorption by attenuating H2O2 accumulation. Nat Commun 5:3773PubMedCrossRef Bartell SM, Kim HN, Ambrogini E, Han L, Iyer S, Serra Ucer S, Rabinovitch P, Jilka RL, Weinstein RS, Zhao H, O'Brien CA, Manolagas SC, Almeida M (2014) FoxO proteins restrain osteoclastogenesis and bone resorption by attenuating H2O2 accumulation. Nat Commun 5:3773PubMedCrossRef
23.
Zurück zum Zitat Liu C, Jiang D (2017) High glucose-induced LIF suppresses osteoblast differentiation via regulating STAT3/SOCS3 signaling. Cytokine 91:132–139PubMedCrossRef Liu C, Jiang D (2017) High glucose-induced LIF suppresses osteoblast differentiation via regulating STAT3/SOCS3 signaling. Cytokine 91:132–139PubMedCrossRef
24.
Zurück zum Zitat Pramojanee SN, Phimphilai M, Chattipakorn N, Chattipakorn SC (2014) Possible roles of insulin signaling in osteoblasts. Endocr Res 39:144–151PubMedCrossRef Pramojanee SN, Phimphilai M, Chattipakorn N, Chattipakorn SC (2014) Possible roles of insulin signaling in osteoblasts. Endocr Res 39:144–151PubMedCrossRef
25.
Zurück zum Zitat Akune T, Ogata N, Hoshi K, Kubota N, Terauchi Y, Tobe K, Takagi H, Azuma Y, Kadowaki T, Nakamura K, Kawaguchi H (2002) Insulin receptor substrate-2 maintains predominance of anabolic function over catabolic function of osteoblasts. J Cell Biol 159:147–156PubMedPubMedCentralCrossRef Akune T, Ogata N, Hoshi K, Kubota N, Terauchi Y, Tobe K, Takagi H, Azuma Y, Kadowaki T, Nakamura K, Kawaguchi H (2002) Insulin receptor substrate-2 maintains predominance of anabolic function over catabolic function of osteoblasts. J Cell Biol 159:147–156PubMedPubMedCentralCrossRef
26.
Zurück zum Zitat Yang J, Zhang X, Wang W, Liu J (2010) Insulin stimulates osteoblast proliferation and differentiation through ERK and PI3K in MG-63 cells. Cell Biochem Funct 28:334–341PubMedCrossRef Yang J, Zhang X, Wang W, Liu J (2010) Insulin stimulates osteoblast proliferation and differentiation through ERK and PI3K in MG-63 cells. Cell Biochem Funct 28:334–341PubMedCrossRef
27.
Zurück zum Zitat Ogata N, Chikazu D, Kubota N, Terauchi Y, Tobe K, Azuma Y, Ohta T, Kadowki T, Nakamura K, Kawaguchi H (2000) Insulin receptor substrate-1 in osteoblast is indispensable for maintaining bone turnover. J Clin Investig 105:935–943PubMedCrossRefPubMedCentral Ogata N, Chikazu D, Kubota N, Terauchi Y, Tobe K, Azuma Y, Ohta T, Kadowki T, Nakamura K, Kawaguchi H (2000) Insulin receptor substrate-1 in osteoblast is indispensable for maintaining bone turnover. J Clin Investig 105:935–943PubMedCrossRefPubMedCentral
28.
Zurück zum Zitat Fulzele K, Riddle RC, DiGirolamo DJ, Cao X, Wan C, Chen D, Faugere MC, Aja S, Hussain MA, Bruning JC, Clemens TL (2010) Insulin receptor signaling in osteoblasts regulates postnatal bone acquisition and body composition. Cell 142:309–319PubMedPubMedCentralCrossRef Fulzele K, Riddle RC, DiGirolamo DJ, Cao X, Wan C, Chen D, Faugere MC, Aja S, Hussain MA, Bruning JC, Clemens TL (2010) Insulin receptor signaling in osteoblasts regulates postnatal bone acquisition and body composition. Cell 142:309–319PubMedPubMedCentralCrossRef
29.
Zurück zum Zitat Pacicca DM, Brown T, Watkins D, Kover K, Yan Y, Prideaux M, Bonewald L (2019) Elevated glucose acts directly on osteocytes to increase sclerostin expression in diabetes. Sci Rep 9:17353PubMedPubMedCentralCrossRef Pacicca DM, Brown T, Watkins D, Kover K, Yan Y, Prideaux M, Bonewald L (2019) Elevated glucose acts directly on osteocytes to increase sclerostin expression in diabetes. Sci Rep 9:17353PubMedPubMedCentralCrossRef
30.
Zurück zum Zitat Sun T, Yan Z, Cai J, Shao X, Wang D, Ding Y, Feng Y, Yang J, Luo E, Feng X, Jing D (2019) Effects of mechanical vibration on cell morphology, proliferation, apoptosis, and cytokine expression/secretion in osteocyte-like MLO-Y4 cells exposed to high glucose. Cell Biol Int Sun T, Yan Z, Cai J, Shao X, Wang D, Ding Y, Feng Y, Yang J, Luo E, Feng X, Jing D (2019) Effects of mechanical vibration on cell morphology, proliferation, apoptosis, and cytokine expression/secretion in osteocyte-like MLO-Y4 cells exposed to high glucose. Cell Biol Int
31.
Zurück zum Zitat Wittrant Y, Gorin Y, Woodruff K, Horn D, Abboud HE, Mohan S, Abboud-Werner SL (2008) High d(+)glucose concentration inhibits RANKL-induced osteoclastogenesis. Bone 42:1122–1130PubMedPubMedCentralCrossRef Wittrant Y, Gorin Y, Woodruff K, Horn D, Abboud HE, Mohan S, Abboud-Werner SL (2008) High d(+)glucose concentration inhibits RANKL-induced osteoclastogenesis. Bone 42:1122–1130PubMedPubMedCentralCrossRef
32.
Zurück zum Zitat Cai ZY, Yang B, Shi YX, Zhang WL, Liu F, Zhao W, Yang MW (2018) High glucose downregulates the effects of autophagy on osteoclastogenesis via the AMPK/mTOR/ULK1 pathway. Biochem Biophys Res Commun 503:428–435PubMedCrossRef Cai ZY, Yang B, Shi YX, Zhang WL, Liu F, Zhao W, Yang MW (2018) High glucose downregulates the effects of autophagy on osteoclastogenesis via the AMPK/mTOR/ULK1 pathway. Biochem Biophys Res Commun 503:428–435PubMedCrossRef
33.
Zurück zum Zitat Shen Y, Guo S, Chen G, Ding Y, Wu Y, Tian W (2018) Hyperglycemia Induces osteoclastogenesis and bone destruction through the activation of Ca(2+)/calmodulin-dependent protein kinase II. Calcif Tissue Int Shen Y, Guo S, Chen G, Ding Y, Wu Y, Tian W (2018) Hyperglycemia Induces osteoclastogenesis and bone destruction through the activation of Ca(2+)/calmodulin-dependent protein kinase II. Calcif Tissue Int
34.
Zurück zum Zitat Tanaka T, Takei Y, Yamanouchi D (2016) Hyperglycemia suppresses calcium phosphate–induced aneurysm formation through inhibition of macrophage activation. J Am Heart Assoc 5 Tanaka T, Takei Y, Yamanouchi D (2016) Hyperglycemia suppresses calcium phosphate–induced aneurysm formation through inhibition of macrophage activation. J Am Heart Assoc 5
35.
Zurück zum Zitat Kurihara C, Tanaka T, Yamanouchi D (2017) Hyperglycemia attenuates receptor activator of NF-κB ligand-induced macrophage activation by suppressing insulin signaling. J Surg Res 214:168–175PubMedCrossRef Kurihara C, Tanaka T, Yamanouchi D (2017) Hyperglycemia attenuates receptor activator of NF-κB ligand-induced macrophage activation by suppressing insulin signaling. J Surg Res 214:168–175PubMedCrossRef
36.
Zurück zum Zitat Xiao E, Mattos M, Vieira GHA, Chen S, Correa JD, Wu Y, Albiero ML, Bittinger K, Graves DT (2017) Diabetes enhances IL-17 expression and alters the oral microbiome to increase its pathogenicity. Cell Host Microbe 22:e4 Xiao E, Mattos M, Vieira GHA, Chen S, Correa JD, Wu Y, Albiero ML, Bittinger K, Graves DT (2017) Diabetes enhances IL-17 expression and alters the oral microbiome to increase its pathogenicity. Cell Host Microbe 22:e4
37.
Zurück zum Zitat Kim HS, Park JW, Yeo SI, Choi BJ, Suh JY (2006) Effects of high glucose on cellular activity of periodontal ligament cells in vitro. Diabetes Res Clin Pract 74:41–47PubMedCrossRef Kim HS, Park JW, Yeo SI, Choi BJ, Suh JY (2006) Effects of high glucose on cellular activity of periodontal ligament cells in vitro. Diabetes Res Clin Pract 74:41–47PubMedCrossRef
38.
Zurück zum Zitat Kato H, Taguchi Y, Tominaga K, Kimura D, Yamawaki I, Noguchi M, Yamauchi N, Tamura I, Tanaka A, Umeda M (2016) High glucose concentrations suppress the proliferation of human periodontal ligament stem cells and their differentiation into osteoblasts. J Periodontol 87:e44–51PubMedCrossRef Kato H, Taguchi Y, Tominaga K, Kimura D, Yamawaki I, Noguchi M, Yamauchi N, Tamura I, Tanaka A, Umeda M (2016) High glucose concentrations suppress the proliferation of human periodontal ligament stem cells and their differentiation into osteoblasts. J Periodontol 87:e44–51PubMedCrossRef
39.
Zurück zum Zitat Li M, Li CZ (2016) High glucose improves healing of periodontal wound by inhibiting proliferation and osteogenetic differentiation of human PDL cells. Int Wound J 13:39–43PubMedCrossRef Li M, Li CZ (2016) High glucose improves healing of periodontal wound by inhibiting proliferation and osteogenetic differentiation of human PDL cells. Int Wound J 13:39–43PubMedCrossRef
40.
Zurück zum Zitat Nishimura F, Naruishi K, Yamada H, Kono T, Takashiba S, Murayama Y (2000) High glucose suppresses cathepsin activity in periodontal-ligament-derived fibroblastic cells. J Dental Res 79:1614–1617CrossRef Nishimura F, Naruishi K, Yamada H, Kono T, Takashiba S, Murayama Y (2000) High glucose suppresses cathepsin activity in periodontal-ligament-derived fibroblastic cells. J Dental Res 79:1614–1617CrossRef
41.
Zurück zum Zitat Lew JH, Naruishi K, Kajiura Y, Nishikawa Y, Ikuta T, Kido JI, Nagata T (2018) High glucose-mediated cytokine regulation in gingival fibroblasts and THP-1 macrophage: a possible mechanism of severe periodontitis with diabetes. Cell Physiol Biochem 50:973–986PubMedCrossRef Lew JH, Naruishi K, Kajiura Y, Nishikawa Y, Ikuta T, Kido JI, Nagata T (2018) High glucose-mediated cytokine regulation in gingival fibroblasts and THP-1 macrophage: a possible mechanism of severe periodontitis with diabetes. Cell Physiol Biochem 50:973–986PubMedCrossRef
42.
Zurück zum Zitat Li X, Ma XY, Feng YF, Ma ZS, Wang J, Ma TC, Qi W, Lei W, Wang L (2015) Osseointegration of chitosan coated porous titanium alloy implant by reactive oxygen species-mediated activation of the PI3K/AKT pathway under diabetic conditions. Biomaterials 36:44–54PubMedCrossRef Li X, Ma XY, Feng YF, Ma ZS, Wang J, Ma TC, Qi W, Lei W, Wang L (2015) Osseointegration of chitosan coated porous titanium alloy implant by reactive oxygen species-mediated activation of the PI3K/AKT pathway under diabetic conditions. Biomaterials 36:44–54PubMedCrossRef
43.
Zurück zum Zitat Jiang H, Ma X, Zhou W, Dong K, Rausch-Fan X, Liu S, Li S (2017) The effects of hierarchical micro/nano-structured titanium surface on osteoblast proliferation and differentiation under diabetic conditions. Implant Dent 26:263–269PubMedCrossRef Jiang H, Ma X, Zhou W, Dong K, Rausch-Fan X, Liu S, Li S (2017) The effects of hierarchical micro/nano-structured titanium surface on osteoblast proliferation and differentiation under diabetic conditions. Implant Dent 26:263–269PubMedCrossRef
44.
Zurück zum Zitat Kwon H, Lim W, Kim J, Jeon S, Kim S, Karna S, Cha H, Kim O, Choi H (2013) Effect of 635 nm irradiation on high glucose-boosted inflammatory responses in LPS-induced MC3T3-E1 cells. Lasers Med Sci 28:717–724PubMedCrossRef Kwon H, Lim W, Kim J, Jeon S, Kim S, Karna S, Cha H, Kim O, Choi H (2013) Effect of 635 nm irradiation on high glucose-boosted inflammatory responses in LPS-induced MC3T3-E1 cells. Lasers Med Sci 28:717–724PubMedCrossRef
45.
Zurück zum Zitat Sun M, Yang J, Wang J, Hao T, Jiang D, Bao G, Liu G (2016) TNF-alpha is upregulated in T2DM patients with fracture and promotes the apoptosis of osteoblast cells in vitro in the presence of high glucose. Cytokine 80:35–42PubMedCrossRef Sun M, Yang J, Wang J, Hao T, Jiang D, Bao G, Liu G (2016) TNF-alpha is upregulated in T2DM patients with fracture and promotes the apoptosis of osteoblast cells in vitro in the presence of high glucose. Cytokine 80:35–42PubMedCrossRef
46.
Zurück zum Zitat Feng YF, Wang L, Zhang Y, Li X, Ma ZS, Zou JW, Lei W, Zhang ZY (2013) Effect of reactive oxygen species overproduction on osteogenesis of porous titanium implant in the present of diabetes mellitus. Biomaterials 34:2234–2243PubMedCrossRef Feng YF, Wang L, Zhang Y, Li X, Ma ZS, Zou JW, Lei W, Zhang ZY (2013) Effect of reactive oxygen species overproduction on osteogenesis of porous titanium implant in the present of diabetes mellitus. Biomaterials 34:2234–2243PubMedCrossRef
47.
Zurück zum Zitat Takagi M, Kasayama S, Yamamoto T, Motomura T, Hashimoto K, Yamamoto H, Sato B, Okada S, Kishimoto T (1997) Advanced glycation endproducts stimulate interleukin-6 production by human bone-derived cells. J Bone Miner Res 12:439–446PubMedCrossRef Takagi M, Kasayama S, Yamamoto T, Motomura T, Hashimoto K, Yamamoto H, Sato B, Okada S, Kishimoto T (1997) Advanced glycation endproducts stimulate interleukin-6 production by human bone-derived cells. J Bone Miner Res 12:439–446PubMedCrossRef
48.
Zurück zum Zitat Miranda C, Giner M, Montoya MJ, Vazquez MA, Miranda MJ, Perez-Cano R (2016) Influence of high glucose and advanced glycation end-products (ages) levels in human osteoblast-like cells gene expression. BMC Musculoskelet Disord 17:377PubMedPubMedCentralCrossRef Miranda C, Giner M, Montoya MJ, Vazquez MA, Miranda MJ, Perez-Cano R (2016) Influence of high glucose and advanced glycation end-products (ages) levels in human osteoblast-like cells gene expression. BMC Musculoskelet Disord 17:377PubMedPubMedCentralCrossRef
49.
Zurück zum Zitat Hu XF, Wang L, Lu YZ, Xiang G, Wu ZX, Yan YB, Zhang Y, Zhao X, Zang Y, Shi L, Lei W, Feng YF (2017) Adiponectin improves the osteointegration of titanium implant under diabetic conditions by reversing mitochondrial dysfunction via the AMPK pathway in vivo and in vitro. Acta Biomater 61:233–248PubMedCrossRef Hu XF, Wang L, Lu YZ, Xiang G, Wu ZX, Yan YB, Zhang Y, Zhao X, Zang Y, Shi L, Lei W, Feng YF (2017) Adiponectin improves the osteointegration of titanium implant under diabetic conditions by reversing mitochondrial dysfunction via the AMPK pathway in vivo and in vitro. Acta Biomater 61:233–248PubMedCrossRef
50.
Zurück zum Zitat Tanaka K, Yamaguchi T, Kanazawa I, Sugimoto T (2015) Effects of high glucose and advanced glycation end products on the expressions of sclerostin and RANKL as well as apoptosis in osteocyte-like MLO-Y4-A2 cells. Biochem Biophys Res Commun 461:193–199PubMedCrossRef Tanaka K, Yamaguchi T, Kanazawa I, Sugimoto T (2015) Effects of high glucose and advanced glycation end products on the expressions of sclerostin and RANKL as well as apoptosis in osteocyte-like MLO-Y4-A2 cells. Biochem Biophys Res Commun 461:193–199PubMedCrossRef
51.
Zurück zum Zitat Tessaro FHG, Ayala TS, Nolasco EL, Bella LM, Martins JO (2017) Insulin influences LPS-induced TNF-alpha and IL-6 release through distinct pathways in mouse macrophages from different compartments. Cell Physiol Biochem 42:2093–2104PubMedCrossRef Tessaro FHG, Ayala TS, Nolasco EL, Bella LM, Martins JO (2017) Insulin influences LPS-induced TNF-alpha and IL-6 release through distinct pathways in mouse macrophages from different compartments. Cell Physiol Biochem 42:2093–2104PubMedCrossRef
52.
Zurück zum Zitat Zheng J, Chen S, Albiero ML, Vieira GHA, Wang J, Feng JQ, Graves DT (2018) Diabetes activates periodontal ligament fibroblasts via NF-κB in vivo. J Dental Res 97:580–588CrossRef Zheng J, Chen S, Albiero ML, Vieira GHA, Wang J, Feng JQ, Graves DT (2018) Diabetes activates periodontal ligament fibroblasts via NF-κB in vivo. J Dental Res 97:580–588CrossRef
53.
Zurück zum Zitat Li DX, Deng TZ, Lv J, Ke J (2014) Advanced glycation end products (AGEs) and their receptor (RAGE) induce apoptosis of periodontal ligament fibroblasts. Braz J Med Biol Res 47:1036–1043PubMedPubMedCentralCrossRef Li DX, Deng TZ, Lv J, Ke J (2014) Advanced glycation end products (AGEs) and their receptor (RAGE) induce apoptosis of periodontal ligament fibroblasts. Braz J Med Biol Res 47:1036–1043PubMedPubMedCentralCrossRef
54.
Zurück zum Zitat Li Z, Li C, Zhou Y, Chen W, Luo G, Zhang Z, Wang H, Zhang Y, Xu D, Sheng P (2016) Advanced glycation end products biphasically modulate bone resorption in osteoclast-like cells. Am J Physiol Endocrinol Metab 310:E355–E366PubMedCrossRef Li Z, Li C, Zhou Y, Chen W, Luo G, Zhang Z, Wang H, Zhang Y, Xu D, Sheng P (2016) Advanced glycation end products biphasically modulate bone resorption in osteoclast-like cells. Am J Physiol Endocrinol Metab 310:E355–E366PubMedCrossRef
55.
Zurück zum Zitat Wang L, Hu X, Ma X, Ma Z, Zhang Y, Lu Y, Li X, Lei W, Feng Y (2016) Promotion of osteointegration under diabetic conditions by tantalum coating-based surface modification on 3-dimensional printed porous titanium implants. Colloids Surf B Biointerfaces 148:440–452PubMedCrossRef Wang L, Hu X, Ma X, Ma Z, Zhang Y, Lu Y, Li X, Lei W, Feng Y (2016) Promotion of osteointegration under diabetic conditions by tantalum coating-based surface modification on 3-dimensional printed porous titanium implants. Colloids Surf B Biointerfaces 148:440–452PubMedCrossRef
56.
Zurück zum Zitat Ma XY, Feng YF, Wang TS, Lei W, Li X, Zhou DP, Wen XX, Yu HL, Xiang LB, Wang L (2017) Involvement of FAK-mediated BMP-2/Smad pathway in mediating osteoblast adhesion and differentiation on nano-HA/chitosan composite coated titanium implant under diabetic conditions. Biomater Sci 6:225–238PubMedCrossRef Ma XY, Feng YF, Wang TS, Lei W, Li X, Zhou DP, Wen XX, Yu HL, Xiang LB, Wang L (2017) Involvement of FAK-mediated BMP-2/Smad pathway in mediating osteoblast adhesion and differentiation on nano-HA/chitosan composite coated titanium implant under diabetic conditions. Biomater Sci 6:225–238PubMedCrossRef
57.
Zurück zum Zitat Ehnert S, Freude T, Ihle C, Mayer L, Braun B, Graeser J, Flesch I, Stockle U, Nussler AK, Pscherer S (2015) Factors circulating in the blood of type 2 diabetes mellitus patients affect osteoblast maturation—description of a novel in vitro model. Exp Cell Res 332:247–258PubMedCrossRef Ehnert S, Freude T, Ihle C, Mayer L, Braun B, Graeser J, Flesch I, Stockle U, Nussler AK, Pscherer S (2015) Factors circulating in the blood of type 2 diabetes mellitus patients affect osteoblast maturation—description of a novel in vitro model. Exp Cell Res 332:247–258PubMedCrossRef
58.
Zurück zum Zitat Zhang Y, Yang JH (2013) Activation of the PI3K/Akt pathway by oxidative stress mediates high glucose-induced increase of adipogenic differentiation in primary rat osteoblasts. J Cell Biochem 114:2595–2602PubMedCrossRef Zhang Y, Yang JH (2013) Activation of the PI3K/Akt pathway by oxidative stress mediates high glucose-induced increase of adipogenic differentiation in primary rat osteoblasts. J Cell Biochem 114:2595–2602PubMedCrossRef
Metadaten
Titel
Impact of diabetes mellitus simulations on bone cell behavior through in vitro models
verfasst von
Yihan Li
Annie Shrestha
Hongmei Zhang
Lingjie Li
Dize Li
Tiwei Fu
Jinlin Song
Ping Ji
Yuanding Huang
Tao Chen
Publikationsdatum
16.05.2020
Verlag
Springer Singapore
Erschienen in
Journal of Bone and Mineral Metabolism / Ausgabe 5/2020
Print ISSN: 0914-8779
Elektronische ISSN: 1435-5604
DOI
https://doi.org/10.1007/s00774-020-01101-5

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