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20.11.2018 | Review

Impact of endometriosis on risk of ovarian, endometrial and cervical cancers: a meta-analysis

verfasst von: Jia li, Ruijuan Liu, Shifeng Tang, Fubin Feng, Cun Liu, Lu Wang, Wenge Zhao, Tingting Zhang, Yan Yao, Xue Wang, Changgang Sun

Erschienen in: Archives of Gynecology and Obstetrics | Ausgabe 1/2019

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Abstract

Purpose

The risks of gynecologic cancer have not been well established in women with endometriosis. The objective of the present study was to investigate the influence of endometriosis on the risk for three gynecologic cancer (ovarian cancer, endometrial cancer and cervical cancer).

Methods

We gathered updated evidence about the risk relationship between endometriosis and gynecologic cancers by conducting a comprehensive search of several medical literature electronic databases, including PubMed, Embase and the Cochrane Library. The design and quality of all studies were evaluated using the Newcastle–Ottawa Scale (NOS), and a random-effects model was used to calculate pooled risk ratio (RR).

Results

Of the 8538 articles our search produced, we selected 25 qualified studies, including 16 cohort studies and 9 case–control studies. Patients with endometriosis had both an increased risk of ovarian cancer [RR 1.964; 95% CI (1.685, 2.290)]. The risk of endometrial cancer (EC) is not necessarily higher in patients with endometriosis [RR 1.176, 95% CI (0.878, 1.575)]. Endometriosis was not associated with an increased risk for cervical cancer (CC) [RR 0.670, 95% CI (0.537, 0.838)].

Conclusions

Patients with endometriosis need to be closely observed and rechecked regularly to prevent malignant changes.

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Titel: Impact of endometriosis on risk of ovarian, endometrial and cervical cancers: a meta-analysis
verfasst von: Jia li
Ruijuan Liu
Shifeng Tang
Fubin Feng
Cun Liu
Lu Wang
Wenge Zhao
Tingting Zhang
Yan Yao
Xue Wang
Changgang Sun
Publikationsdatum: 20.11.2018
Verlag: Springer Berlin Heidelberg
Erschienen in: Archives of Gynecology and Obstetrics / Ausgabe 1/2019
Print ISSN: 0932-0067
Elektronische ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-018-4968-1

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Impact of endometriosis on risk of ovarian, endometrial and cervical cancers: a meta-analysis