Skip to main content
Erschienen in: European Archives of Psychiatry and Clinical Neuroscience 2/2019

05.10.2018 | Original Paper

Impact of FAAH genetic variation on fronto-amygdala function during emotional processing

verfasst von: Anne Gärtner, Denise Dörfel, Kersten Diers, Stephanie H. Witt, Alexander Strobel, Burkhard Brocke

Erschienen in: European Archives of Psychiatry and Clinical Neuroscience | Ausgabe 2/2019

Einloggen, um Zugang zu erhalten

Abstract

Recent translational studies identified a common endocannabinoid polymorphism, FAAH C385A, in the gene for the fatty acid amide hydrolase (FAAH). This polymorphism alters endocannabinoid anandamide levels, which are known to be involved in the fronto-amygdala circuitry implicated in mood regulation and anxiety-like behaviors. While it has been shown that the variant that selectively enhances fronto-amygdala connectivity at rest is associated with decreased anxiety-like behaviors, no study so far has investigated whether this finding of FAAH-related differential plasticity extends to task-related differential functional expression and regulation during negative emotional processing. Using an imaging genetics approach, this study aimed to replicate and extend prior findings by examining functional activity and task-related connectivity in fronto-amygdala regions during emotion reactivity and emotional down-regulation of negative affect. Therefore, 48 healthy young adults underwent a functional MRI resting state measurement, completed an emotion regulation paradigm and provided self-reports on anxiety and use of emotion regulation strategies. In line with previous studies, preliminary evidence suggests that A-allele carriers demonstrate stronger fronto-amygdala connectivity during rest. In addition, exploratory whole-brain analyses indicate differential functional activity of A-allele carriers during emotion reactivity and emotion regulation. There were no associations with anxiety-related self-reports and use of emotional regulation strategies. Further research using larger samples and polygenic approaches is indicated to clarify the precise role and its underlying mechanisms in emotion processing.
Anhänge
Nur mit Berechtigung zugänglich
Literatur
7.
Zurück zum Zitat Botvinick MM, Braver TS, Barch DM, Carter CS, Cohen JD (2001) Conflict monitoring and cognitive control. Psychol Rev 108(3):624–652CrossRef Botvinick MM, Braver TS, Barch DM, Carter CS, Cohen JD (2001) Conflict monitoring and cognitive control. Psychol Rev 108(3):624–652CrossRef
33.
Zurück zum Zitat Gunduz-Cinar O, MacPherson KP, Cinar R, Gamble-George J, Sugden K, Williams B, Holmes A et al (2013) Convergent translational evidence of a role for anandamide in amygdala-mediated fear extinction, threat processing and stress-reactivity. Mol Psychiatry 18(7):813–823. https://doi.org/10.1038/mp.2012.72 CrossRefPubMed Gunduz-Cinar O, MacPherson KP, Cinar R, Gamble-George J, Sugden K, Williams B, Holmes A et al (2013) Convergent translational evidence of a role for anandamide in amygdala-mediated fear extinction, threat processing and stress-reactivity. Mol Psychiatry 18(7):813–823. https://​doi.​org/​10.​1038/​mp.​2012.​72 CrossRefPubMed
44.
Zurück zum Zitat Krohne HW, Egloff B, Kohlmann CW, Tausch A (1996) Untersuchungen mit einer deutschen Version der “Positive and Negative Affect Schedule” (PANAS). Diagnostica 42:139–156 Krohne HW, Egloff B, Kohlmann CW, Tausch A (1996) Untersuchungen mit einer deutschen Version der “Positive and Negative Affect Schedule” (PANAS). Diagnostica 42:139–156
45.
Zurück zum Zitat Krüger G, Glover GH (2001) Physiological noise in oxygenation-sensitive magnetic resonance imaging. Magn Reson Med 46(4):631–637CrossRef Krüger G, Glover GH (2001) Physiological noise in oxygenation-sensitive magnetic resonance imaging. Magn Reson Med 46(4):631–637CrossRef
48.
Zurück zum Zitat Lang PJ, Bradley MM, Cuthbert BN (1999) International affective picture system (IAPS): instruction manual and affective ratings (Vol. Center for Research in Psychophysiology). University of Florida, Gainesville Lang PJ, Bradley MM, Cuthbert BN (1999) International affective picture system (IAPS): instruction manual and affective ratings (Vol. Center for Research in Psychophysiology). University of Florida, Gainesville
49.
Zurück zum Zitat Laux L, Glanzmann P, Schaffner P, Spielberger CD (1981) Das State-Trait-Angstinventar (STAI). Beltz, Weinheim Laux L, Glanzmann P, Schaffner P, Spielberger CD (1981) Das State-Trait-Angstinventar (STAI). Beltz, Weinheim
83.
Zurück zum Zitat Tzourio-Mazoyer N, Landeau B, Papathanassiou D, Crivello F, Etard O, Delcroix N, Joliot M et al (2002) Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain. NeuroImage 15(1):273–289. https://doi.org/10.1006/nimg.2001.0978 CrossRef Tzourio-Mazoyer N, Landeau B, Papathanassiou D, Crivello F, Etard O, Delcroix N, Joliot M et al (2002) Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain. NeuroImage 15(1):273–289. https://​doi.​org/​10.​1006/​nimg.​2001.​0978 CrossRef
86.
Zurück zum Zitat Wessa M, Kanske P, Neumeister P, Bode K, Heissler J, Schönfelder S (2010) EmoPicS: Subjektive und psychophysiologische Evaluation neuen Bildmaterials für die klinischbiopsychologische Forschung [EmoPicS: Subjective and psychophysiological evaluation of new imagery for clinical biopsychological research]. Z Klin Psychol Psychother Supplement 1:11–77 Wessa M, Kanske P, Neumeister P, Bode K, Heissler J, Schönfelder S (2010) EmoPicS: Subjektive und psychophysiologische Evaluation neuen Bildmaterials für die klinischbiopsychologische Forschung [EmoPicS: Subjective and psychophysiological evaluation of new imagery for clinical biopsychological research]. Z Klin Psychol Psychother Supplement 1:11–77
Metadaten
Titel
Impact of FAAH genetic variation on fronto-amygdala function during emotional processing
verfasst von
Anne Gärtner
Denise Dörfel
Kersten Diers
Stephanie H. Witt
Alexander Strobel
Burkhard Brocke
Publikationsdatum
05.10.2018
Verlag
Springer Berlin Heidelberg
Erschienen in
European Archives of Psychiatry and Clinical Neuroscience / Ausgabe 2/2019
Print ISSN: 0940-1334
Elektronische ISSN: 1433-8491
DOI
https://doi.org/10.1007/s00406-018-0944-9

Weitere Artikel der Ausgabe 2/2019

European Archives of Psychiatry and Clinical Neuroscience 2/2019 Zur Ausgabe

Update Psychiatrie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.