Background
Rheumatoid arthritis (RA) is a chronic inflammatory disease that affects multiple joints, especially the small joints of the hands and feet [
1,
2]. Chronic joint inflammation results in synovial thickening, the production of excessive joint fluid, and damage to cartilage and bones, which can lead to permanent joint destruction and disability [
1]. It is thought that in the early stages of the disease joint inflammation affects daily functioning mainly due to pain and swelling, while in later stages of the disease joint destruction and deformity increase functional impairment [
3].
Foot involvement is a major cause of disability in RA [
4], and can lead to a deterioration in daily activity and quality of life [
5,
6]. Approximately 80–90% of patients with RA experience foot pain during the course of the disease [
1,
5,
7,
8]. Yet, despite the large number of RA patients with foot complaints, these are frequently overlooked when caring for patients with multiple joint pains and deformities. For example, the disease activity score (DAS)-28 is the most widely used assessment tool of disease activity in RA, but the joints in the foot are not included in the 28-joint count [
9]. Even patients in a remission state may suffer from foot pain [
10,
11].
The foot is divided into three regions (the forefoot, midfoot and hindfoot). The forefoot is composed of the metatarsal bones and the phalanges connected by the metatarsophalangeal (MTP) and interphalangeal (IP) joints. The forefoot acts as a lever during the pressing phase of the gait. Forefoot deformity is characterized by hallux valgus and subluxation of the MTP joints [
6]. The foot impairment caused by RA most commonly affects the forefoot, and symptoms begin in the MTP joints in most cases [
5,
8,
12]. The midfoot joint, including naviculocuneiform joint and tarsometatarsal (TMT) joint, constitutes the longitudinal arch of the foot and allows the load to be transferred to the forefoot during gait [
12,
13]. Additional functions provided by the midfoot are the ability to walk on uneven ground and to absorb shock [
7]. The midfoot is not commonly affected on its own but is involved in 40–60% of patients with RA [
6,
12]. The hindfoot joint, including the talonavicular, calcaneocuboid and talocalcaneal (also known as subtalar) joints, performs the side-to-side motion of the foot and provides stability at the initiation of the foot strike and is involved in 30–60% of RA cases [
6,
12,
14]. It is also less frequently involved in the absence of midtarsal- and MTP joint disease. The ankle permits two types of movement, dorsiflexion and plantar flexion and contributes to lower limb stability [
14]. The ankle joint is less commonly involved than other joints of the foot. RA involvement of the ankle joint is seen in approximately 9–26% of patients [
4,
14,
15].
Numerous studies have reported an association between RA involvement or deformity of the forefoot in RA and functional disability [
16‐
21]. In those cases, orthotic devices and surgical treatment are able to relieve pain and improve function [
14]. However, there are a few studies on the effects of midfoot- and hindfoot arthritis in RA [
15,
22,
23]. The purpose of the present study was to assess the prevalence of midfoot and hindfoot involvement and its impact on functional disability in Korean patients with RA.
Discussion
The aim of this study was to assess the prevalence of midfoot and hindfoot involvement, and its effect on functional disability in Korean patients with RA. Hindfoot involvement was most common, and midfoot involvement was as common as forefoot involvement. Foot involvement was associated with poor quality of life and functional disability. Of the various groups, those with midfoot involvement had the greatest functional disability, and hindfoot involvement and midfoot involvement were risk factors for functional disability and walking disability, respectively.
We found that a total of 61.7% of patients had foot or ankle RA involvement, which is a somewhat lower prevalence than in previous reports; the reported prevalence rates of RA foot or ankle involvement have varied from 64% to 96.2% [
5‐
7,
28]. The reasons for our lower prevalence are that our patients were relatively young, their disease was of short duration, and many were receiving biological agents. It has been previously reported that the forefoot is most commonly affected in RA [
2,
4,
5,
7]. In a previous report, the prevalences of forefoot, midfoot, hindfoot and ankle radiographic involvement in RA were 88%, 62%, 32% and 26%, respectively [
4]. However, hindfoot involvement was most common and midfoot RA involvement was as common as forefoot involvement in our study. The difference in the order of frequency of involvement according to location is probably due differences of definition. Since the reported extent and degree of involvement of foot joints varies greatly between studies a consensus definition may be required to permit reliable comparisons between studies, cross-sectional design.
In a previous report, foot and ankle joint destruction was divided into 5 clusters: normal, forefoot, midfoot, mid-hindfoot and combined type. Of these, the mid-hindfoot and combined type deformities showed a significant change in functional disability and decrease in walking ability [
6]. Although a slightly different definition of foot involvement was used, the midfoot and hindfoot involvement groups also had greater functional disability in our study. In addition, midfoot involvement and hindfoot involvement were risk factors for walking disability and total functional disability in this study. Therefore, midfoot and hindfoot arthritis is likely to be important for the function and activity levels of RA patients.
A previous study showed that longer disease duration is associated with impaired foot function and reduced walking speed in patients with RA-related foot complaints because of alterations in pressure distribution and gait patterns [
29]. Another study reported a correlation between disease duration and hallux rigidus and claw toe, which are typical forefoot deformities [
7]. Also, the incidence rate of the pes planus, which is common midfoot deformity, increases with longer disease duration in RA patients [
30]. Consistently, our study found that median disease duration was significantly longer in the foot or ankle involvement group than in the non-involvement group.
High BMI was correlated with foot problems in some previous studies [
2,
28] because excessive mechanical load has an effect on joint damage. However, we found no significant difference in BMI between RA patients with foot or ankle involvement and without involvement. In addition, BMI was not associated with functional disability.
Over the last decades, treatment for RA has become more aggressive with the advent of biologic DMARDs. One-third of our patients were treated with biologic DMARDs and a higher proportion of patients those with foot or ankle involvement used biologic DMARDs. This result is consistent with other reports [
19,
31].
A previous study found that damage in the midfoot occurs suddenly and peaks in cases 5–10 years after RA diagnosis. After that period, midfoot injury rates decrease, while mid-hind foot type injuries gradually increase [
6]. In another study, hindfoot involvement was rarely observed in the absence of midtarsal and MTP joint disease [
4]. These results support the hypothesis that midfoot involvement may precede hindfoot involvement. Although our results do not support that hypothesis, if it is correct early intervention for patients with midfoot arthritis could prevent hindfoot impairment and rescue functional capacity.
In RA patients with foot arthritis, medical and surgical treatment options are available to decrease pain and improve function. First, it is important to educate patients on how to carefully inspect their feet carefully and about the necessity of need for regular exercise, which is helpful to stretch tendons, strengthen muscles and maintain maximum range of motion [
14]. Then, we can provide pain relief and resolve joint inflammation through pharmacologic treatments. Orthotic devices, such as shoes, canes and crutches, are useful in ambulation and can provide support to the arch, accommodate a deformed foot and relieve pain. Surgical treatment, including synovectomy and reconstruction, are also helpful in cases of severe inflammation and progressive joint destruction [
8,
12,
13,
32]. Our study highlights the importance of focusing on midfoot and hindfoot problems, and not exclusively forefoot problems, in routine clinical care with physical and radiographic examination for early detection and treatment.
There are a few limitations to our study. First, it had a cross-sectional design and involved a relatively small number of patients. Second, we could not evaluate additional radiographic views such as foot oblique and ankle AP view for more accurate assessment. Third, we could not use quantitative radiographic scoring methods such as the Sharp/van der Heijde Score or Larsen score. Because these scoring system focus on forefoot deformity rather than midfoot or hindfoot deformity. And we lacked information about current treatments for foot arthritis in terms of the use of orthoses, footwear and steroid injection. However, because more than half of the patients had some degree of foot involvement, we were able to use a multivariable model to identify whether foot involvement was a risk factor for functional impairment. Our study is also meaningful in that it is the first study to assess the impact of foot involvement in the three foot sub-sections on functional disability in Korean RA patients. The present study highlights the importance for early detection of focusing on midfoot and hindfoot problems in routine clinical care, together with physical and radiographic examination, rather than exclusively on forefoot problems. Early detection of foot involvement can reduce disability through early treatment. This study may guide a future longitudinal study designed to evaluate how progression of foot involvement impacts on the outcomes of RA patients using radiographic assessment tools that distinguish between RA and osteoarthritis foot involvement.