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Erschienen in: Acta Neuropathologica 2/2017

09.05.2017 | Review

Impact of multiple pathologies on the threshold for clinically overt dementia

verfasst von: Alifiya Kapasi, Charles DeCarli, Julie A. Schneider

Erschienen in: Acta Neuropathologica | Ausgabe 2/2017

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Abstract

Longitudinal clinical–pathological studies have increasingly recognized the importance of mixed pathologies (the coexistence of one or more neurodegenerative and cerebrovascular disease pathologies) as important factors in the development of Alzheimer’s disease (AD) and other forms of dementia. Older persons with AD pathology, often have concomitant cerebrovascular disease pathologies (macroinfarcts, microinfarcts, atherosclerosis, arteriolosclerosis, cerebral amyloid angiopathy) as well as other concomitant neurodegenerative disease pathologies (Lewy bodies, TDP-43, hippocampal sclerosis). These additional pathologies lower the threshold for clinical diagnosis of AD. Many of these findings from pathologic studies, especially for CVD, have been confirmed using sophisticated neuroimaging technologies. In vivo biomarker studies are necessary to provide an understanding of specific pathologic contributions and time course relationships along the spectrum of accumulating pathologies. In this review, we provide a clinical–pathological perspective on the role of multiple brain pathologies in dementia followed by a review of the available clinical and biomarker data on some of the mixed pathologies.
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Metadaten
Titel
Impact of multiple pathologies on the threshold for clinically overt dementia
verfasst von
Alifiya Kapasi
Charles DeCarli
Julie A. Schneider
Publikationsdatum
09.05.2017
Verlag
Springer Berlin Heidelberg
Erschienen in
Acta Neuropathologica / Ausgabe 2/2017
Print ISSN: 0001-6322
Elektronische ISSN: 1432-0533
DOI
https://doi.org/10.1007/s00401-017-1717-7

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