Introduction
Materials and methods
Results
Low-TCBI (N = 149) | Moderate-TCBI (N = 150) | High-TCBI (N = 149) | Very-High (N = 149) | P value | |
---|---|---|---|---|---|
Age | 82.0 (79, 86) | 81.0 (77, 84) | 80.0 (77, 83) | 79.0 (77, 82) | < 0.001 |
Gender, male | 96, 64.4 | 101, 67.3% | 97, 65.1% | 98, 65.8% | 0.959 |
Body weight, kg | 49.2 (43.0, 55.5) | 55.2 (49.9, 61.3) | 57.0 (50.3, 63.8) | 61.6 (54.4, 68.2) | < 0.001 |
Body mass index, kg/m2 | 20.7 (18.6, 22.7) | 22.5 (20.7, 24.2) | 23.2 (21.5, 25.1) | 24.9 (22.7, 26.9) | < 0.001 |
Hypertension | 112, 75.2% | 123, 82.0% | 121, 81.2% | 119, 79.9% | 0.462 |
Systolic blood pressure, mmHg | 125.0 (110.2, 138.0) | 125.5 (113.8, 142.3) | 129.0 (117.0, 143.0) | 130.0 (120.0, 143.0) | 0.03 |
Diabetes mellitus | 45, 30.2% | 45, 30.0% | 50, 33.6% | 53, 35.6% | 0.683 |
HbA1c, % | 5.7 (5.4, 6.2) | 5.9 (5.5, 6.2) | 6.0 (5.6, 6.5) | 6.0 (5.7, 6.6) | < 0.001 |
Dyslipidemia | 61, 40.9% | 70, 46.7% | 91, 61.1% | 97, 65.5% | < 0.001 |
Triglycerides, mg/dl | 57.0 (46.0, 70.0) | 82.0 (75.8, 93.5) | 115.0 (100.5, 131.0) | 183.0 (144.5, 211.5) | < 0.001 |
Total cholesterol, mg/dl | 146.0 (126.0, 165.5) | 162.0 (143.0, 183.3) | 180.0 (153.0, 201.0) | 198.0 (175.5, 226.0) | < 0.001 |
Peripheral artery disease | 27, 18.1% | 18, 12.1% | 25, 16.8% | 21, 14.1% | 0.47 |
Current smoking | 9, 6.1% | 8, 5.4% | 14, 9.5% | 15, 10.3% | 0.306 |
Acute coronary syndrome | 84, 56.8% | 63, 42.0% | 59, 39.6% | 38, 25.5% | < 0.001 |
Multi-vessel disease | 62, 41.6% | 55, 36.7% | 68, 45.6% | 55, 36.9% | 0.333 |
Number of diseases vessels | 1.0 (1.0, 2.0) | 1.0 (1.0, 2.0) | 1.0 (1.0, 2.0) | 1.0 (1.0, 2.0) | 0.49 |
LVEF, % | 58.0 (47.0, 66.0) | 61.2 (48.9, 70.3) | 62.0 (55.0, 69.0) | 65.0 (58.1, 73.0) | < 0.001 |
LVEF < 40% | 23, 16.1% | 25, 17.2% | 14, 9.7% | 10, 7.0% | 0.023 |
Chronic kidney disease | 84, 56.4% | 82, 54.7% | 86, 57.7% | 95, 63.8 | 0.411 |
Cre, mg/dl | 0.9 (0.7, 1.3) | 0.9 (0.7, 1.1) | 0.9 (0.7, 1.1) | 0.9 (0.8, 1.1) | 0.879 |
eGFR, ml/min/1.73*2 | 55.1 (38.5, 71.1) | 58.7 (41.1, 69.7) | 57.1 (44.6, 67.8) | 55.2 (45.3, 64.0) | 0.813 |
CRP, mg/dl | 0.2 (0.1, 0.6) | 0.1 (0.1, 0.6) | 0.1 (0.1, 0.3) | 0.1 (0.1, 0.4) | 0.381 |
Medication | |||||
Beta blocker | 27, 18.1% | 36, 24.0% | 42, 28.2% | 45, 30.2% | 0.08 |
ACE-inhibitor / ARB | 84, 56.8% | 63, 42.0% | 59, 39.6% | 38, 25.5% | < 0.001 |
Statin | 55, 36.9% | 50, 33.3% | 69, 46.3% | 63, 42.3% | 0.104 |
EPA | 5, 3.4% | 3, 2.0% | 5, 3.4% | 3, 2.0% | 0.791 |
Target lesion of PCI | |||||
LMT | 5, 3.4% | 3, 2.0% | 5, 3.4% | 2, 1.4% | 0.434 |
LAD | 63, 42.6% | 66, 44.9% | 52, 35.6% | 74, 50.0% | |
LCx | 19, 12.8% | 26, 17.7% | 26, 17.8% | 21, 14.2% | |
RCA | 61, 41.2% | 52, 35.4% | 62, 42.5% | 51, 34.5% | |
Bypass graft | 0, 0% | 0, 0% | 1, 0.7% | 0, 0% | |
Total stent length | 20.0 (16.0, 30.0) | 24.0 (16.0, 32.0) | 22.5 (15.0, 32.0) | 23.0 (16.0, 30.8) | 0.644 |
Unadjusted HR (95% CI) | P | Adjusted HR (95% CI) | P | |
---|---|---|---|---|
Low TCBI | 1.780 (1.306–2.425) | < 0.001 | 1.440 (1.034–2.006) | 0.031 |
Age | 1.097 (1.062–1.133) | < 0.001 | 1.063 (1.025–1.101) | 0.001 |
Gender, male | 0.920 (0.677–1.250) | 0.592 | 0.940 (0.676–1.308) | 0.714 |
Statin | 0.463 (0.333–0.645) | < 0.001 | 0.463 (0.322–0.667) | < 0.001 |
Acute coronary syndrome | 1.649 (1.229–2.212) | 0.001 | 1.184 (0.848–1.653) | 0.321 |
LVEF < 40% | 2.206 (1.533–3.173) | < 0.001 | 2.050 (1.396–3.010) | < 0.001 |
Chronic kidney disease | 1.481 (1.087–2.018) | 0.013 | 1.247 (0.901–1.727) | 0.183 |
Peripheral artery disease | 1.361 (0.937–1.978) | 0.106 | 1.212 (0.804–1.828) | 0.358 |
Diabetes mellitus | 1.240 (0.916–1.680) | 0.164 | 1.211 (0.878–1.669) | 0.244 |
Hypertension | 1.019 (0.704–1.474) | 0.920 | 1.045 (0.707–1.546) | 0.824 |